Archons And Mind Parasites And Extremophiles, Oh My!


 

I seem as of late to be using the phrase “in their right mind” a lot.

For instance, I often say that nobody in their right mind should be melancholy to what is happening in the world. No one in their right mind should be ok with the fact that the U.S. government in its U.S. Code has an active biological weapons program that makes it “legal” and “acceptable” to test those biologics, radiation, vaccines, and any other thing for “research purposes” on any and every population in the world, including and especially its own. And no body politic of “people” in its right mind would sit back and allow what the United States government has become in all aspects of politics and war.

Yet the deeds are done, and the crime against us is only getting more and more organized and lethal.

And this leads me to believe that my over-use of this declaratory judgement in assumption of the default belief in the state of right-mindedness might very well be misplaced. And so perhaps it is time to consider the very strange and unbelievable reality that maybe, just maybe, the majority of the population is not in fact in their right minds. And if this is the case, well then it might just be possible that they no longer even have the ability to control their own minds…

More and more I contemplate that those who might read this blog and others like it are in fact seeking answers to questions that cannot be found with an “educated” and “entertained” mind. It is not so much that there is no answer to be found, but rather that the answers that can be found do not conform to the reasoning and intent of the asker of the questions. In other words, the questions that seem unanswerable only appear that way because their askers will not look in the places where those answers might so obviously be hiding.

The difference between history (his story) and fiction, and between science and science fiction, has been so divisively blurred and so masterfully intertwined that most of us have been educated through entertainment to ignore anything resembling reality if it has been before musingly portrayed as a story of science or other fiction. Ironically, while the science fiction of yesterday could be considered the uninhibited dream of what the future could hold, today it seems that fiction is dead, and that the rules and science of fiction have been devolved and redacted, fitting only into the defined tenets of today’s real scientific limitations. Today, fiction writers are not dreaming of future possibilities and dystopias, they are describing the planned future of a dystopian science reality. The limits now placed on the imagination of the writer of fiction seem to be solely based on the current but flexible limitations of the practice of modern science. And so the once vibrant dream of utopian philosophers has seemingly also come to its visionary death, for today’s practitioners within the institution of science have taken up not the study of nature but the art of the alteration and control of nature. Anti-nature…

And so those of us who still feel; we who still conform to and therefore know the natural aspects of empathy, logic, reason, virtue, responsibility, and all that makes up the uniqueness and wonder of man are left hopelessly wondering why everything in the world seems somehow, for lack of a better term, just innately wrong. We search for individual answers that, when thoughtfully placed in connective order, we hope might make up the clear summation of the problem at hand. And yet no matter what, the ultimate answer still seems to lay out of sensual understanding. From our sense of reality, we seek a type of knowledge that very likely cannot be obtained through the ordinary processes and facts that otherwise we may find using the traditional scientific method. For that method was created to specifically study the natural state and order of things. So we must ask ourselves some very disturbing questions:

How can we possibly use this traditional scientific method to find answers when all of nature is being corrupted by the abuse of modern scientific methods?

If science is the study of nature and how it works without the intervention of man, and if at the same time nature itself is being fundamentally altered by the false institution of science, what then should the new definition of modern science be?

More to the point, how can a reasonable researcher use traditional scientific means in logical sequence to accomplish the goals of this new non-traditional science?

What was before the study of the laws of nature is now the study of the destruction of those constants. What was before the craft of benefiting mankind through understanding the natural process is now the craft of overcoming that process to control mankind through control of nature.

So for those who seek provable answers using the traditional scientific method, it is advised that you should go back to watching re-runs of “History Channel Presents.” For today, we are going to delve into what is indeed possible yet seemingly not. And as of yet, there is no proof or test that I can offer you to satisfy your “scientific” curiosity. Instead, for a brief moment, I ask you to consider that what might be the answer to your unanswered questions may very well be so different than you expect that you won’t even wish to bring up the subject to friends and family for fear of ridicule. And honestly, the only reason I am writing this now, with the same contemplation and fear in mind, is that I have a strange feeling that only those of us left out here that are still in our right mind will believe that the following information is perhaps more self-evident than any other explanation.

The great rhetorical mind of the Scottish author and physician Sir Arthur Conan Doyle, a graduate of the University of Edinburgh Medical School no less, might be of import in this endeavor. His character Sherlock Holmes was essentially represented as the crowning authority in the use of forensic science. The word forensic comes from the Latin forēnsis, meaning “of or before the forum (court),” dating to the roman republic. Created in the late 1890’s, detective Holmes was required to use his brain, his logic and his reason to solve the case, for the modern technology of crime scene investigation was not yet in existence, and this allowed many criminals to flee justice.

Today, I ask the same of you, my dear Watson’s…

In the novels based on Sherlock Holmes; those fictional tales about the unorthodox, de-educated, non-conformative detective, it was said of man that, “His ignorance was as remarkable as his knowledge.

Even more remarkably, the fictional detective stated that, “In solving a problem of this sort, the grand thing is to be able to reason backward. That is a very useful accomplishment, and a very easy one, but people do not practise it much. In the everyday affairs of life it is more useful to reason forward, and so the other comes to be neglected. There are fifty who can reason synthetically for one who can reason analytically.” It is my opinion that if you are reading this blog, you may very well be one in fifty.

Of course, his most famous musing concluded that, “When you have eliminated all which is impossible, then whatever remains, however improbable, must be the truth.

But perhaps in light of our current disposition as sentient beings searching for answers to questions that seemingly won’t be answered, it is this quote we should be romancing:  “I fear that if the matter is beyond humanity it is certainly beyond me. Yet we must exhaust all natural explanations before we fall back upon such a theory as this.

In the spirit of this Holmesian deductive reasoning, I hope that the reader will allow herein a presentation of my own theory on why everything in science and in the actions of the leaders of men seem to be centralized on creating a fictional dystopia of mis-used science rather than on the use of science to realize the dream of fictional utopia.

(Que ‘Twilight Zone’ music)

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Warning:
This Is Not Science Fiction!

–=–

In movies, the monster is usually something that you can see. The alien from Alien. The clown from IT. The Martians from Mars Attacks. The Englishmen from Downton Abbey. And who can forget Mega Shark vs. Crocosaurus?

The use of the genre of sci-fi horror movies depicting gruesome monsters and viscously putrefying aliens has created a false dicotomy of left or right opinions regarding what the typical person might be able to believe is possible within the institutional reality of biological science, which today has seemingly crossed the barrier of perception with its primary basis now in the world of the unseen – the less-than-microscopic nano-world of genetic code. “Science” has mapped the genomes of many species, and is now hot on the trail of mapping the epigenetic on/off mechanisms of DNA/RNA encoding that controls gene expression and disease. It is one thing to see how genes are put together to make up life on earth, but an entirely more dangerous thing to have one’s hands on the knowledge and function of turning those gene’s expressions on and off. In this manner, science has become a very frightening brave new world.

The Genome project is now a thing of the past, old news, ancient technology. The Epigenome Project is now where it’s at!

The Human Epigenome Project website explains its surface goals:

The Human Epigenome Project (HEP) aims to identify, catalogue and interpret genome-wide DNA methylation patterns of all human genes in all major tissues. Methylation is the only flexible genomic parameter that can change genome function under exogenous influence. Hence it constitutes the main and so far missing link between genetics, disease and the environment that is widely thought to play a decisive role in the aetiology of virtually all human pathologies. Methylation occurs naturally on cytosine bases at CpG sequences and is involved in controlling the correct expression of genes. Differentially methylated cytosines give rise to distinct patterns specific for tissue type and disease state. Such methylation variable positions (MVPs) are common epigenetic markers. Like single nucleotide polymorphisms (SNPs), they promise to significantly advance our ability to understand and diagnose human disease.

The Human Epigenome Project (HEP) is a public/private collaboration run by the members of the Human Epigenome Consortium. MVPs identified as part of the HEP will be released publicly in accordance with the HEP data release policy.

Source–> http://www.epigenome.org/index.php?page=project

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And just who or what makes up the members of this “consortium?”

Current consortium members:

The Wellcome Trust Sanger Institute is a recognised leader in genome sequencing, high-throughput systems, informatics and analysis of gene function using genetic approaches in a variety of model organisms and humans.

Epigenomics AG is a transatlantic biotechnology company with headquarters in Berlin, Germany and its wholly owned subsidiary in Seattle, Washington, USA, pioneering tomorrow’s personalized medicine by exploiting the information of DNA methylation patterns.

The Centre National de Génotypage is a national research institute set up in 1998 by the French Government in anticipation of using the genome sequencing information for the identification of genes and gene function.

Source–> http://www.epigenome.org/index.php?page=consortium

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Now, if you are not familiar with Margaret Sanger, you really should be. As one of the most famous soft eugenisists, her legacy includes Planned Parenthood and modern birth control. But let’s take a deeper look at this feminist de-populationist, and imagine for a moment if she had her finger on the trigger of modern genetic and epigenetic technology. Planned Parenthood would look a lot differently than it does today.

Surprisingly, even Wikipedia must admit to the truth of the easily found history of her motives (citations and sources left in):

Sanger’s 1920 book endorsed eugenics.

As part of her efforts to promote birth control, Sanger found common cause with proponents of eugenics, believing that they both sought to “assist the race toward the elimination of the unfit.”[84] Sanger was a proponent of negative eugenics, which aims to improve human hereditary traits through social intervention by reducing the reproduction of those who were considered unfit.[85] Sanger’s eugenic policies included an exclusionary immigration policy, free access to birth control methods and full family planning autonomy for the able-minded, and compulsory segregation or sterilization for the profoundly retarded.[86][87] In her book The Pivot of Civilization, she advocated coercion to prevent the “undeniably feeble-minded” from procreating.[88] Although Sanger supported negative eugenics, she asserted that eugenics alone was not sufficient, and that birth control was essential to achieve her goals.[89][90][91]

In contrast with eugenicist William Robinson, who advocated euthanasia for the unfit,[note 9] Sanger wrote, “we [do not] believe that the community could or should send to the lethal chamber the defective progeny resulting from irresponsible and unintelligent breeding.”[92] Similarly, Sanger denounced the aggressive and lethal Nazi eugenics program.[87] In addition, Sanger believed the responsibility for birth control should remain in the hands of able-minded individual parents rather than the state, and that self-determining motherhood was the only unshakable foundation for racial betterment.[89][93]

Sanger also supported restrictive immigration policies. In “A Plan for Peace”, a 1932 essay, she proposed a congressional department to address population problems. She also recommended that immigration exclude thosewhose condition is known to be detrimental to the stamina of the race,” and that sterilization and segregation be applied to those with incurable, hereditary disabilities[86][87][94]

Sanger’s writings echoed ideas about inferiority and loose morals of particular races that were widespread in the contemporary United States.[85] In one “What Every Girl Should Know” commentary, she references popular opinion that Aboriginal Australians were “just a step higher than the chimpanzeewithlittle sexual control,” as compared to thenormal man and Woman.”[78] Elsewhere she bemoaned that traditional sexual ethics“…have in the past revealed their woeful inability to prevent the sexual and racial chaos into which the world has today drifted…”[93]

From 1939 to 1942 Sanger was an honorary delegate of the Birth Control Federation of America, which included a supervisory role—alongside Mary Lasker and Clarence Gamblein the Negro Project, an effort to deliver birth control to poor black people.[100] Sanger wanted the Negro Project to include black ministers in leadership roles, but other supervisors did not. To emphasize the benefits of involving black community leaders, she wrote to Gamble “we do not want word to go out that we want to exterminate the Negro population and the minister is the man who can straighten out that idea if it ever occurs to any of their more rebellious members.” This quote has been cited by Angela Davis to support her claims that Sanger wanted to exterminate black people.[101] However, New York University’s Margaret Sanger Papers Project, argues that in writing that letter, “Sanger recognized that elements within the black community might mistakenly associate the Negro Project with racist sterilization campaigns in the Jim Crow South, unless clergy and other community leaders spread the word that the Project had a humanitarian aim.”[102]

One might perhaps laugh at the caption of this article,
promoting birth control while posing with her own two birthed sons.
Of course, birth control was really intended for the “lesser” races…

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Ironically, but not surprisingly, Sanger’s racially pure mother Anne Higgins went through 18 pregnancies (with 11 live births) in 22 years before dying at the age of 49. Sanger was the sixth of eleven children. But then, she was apparently gifted with good blood from a good race, so that’s just alright now isn’t it?

So why should you, if indeed you are in your right mind, be concerned that the most prominent organization participating in the Genome and Epigenome Projects honor in their titles this eugenicist that promoted racial purity and depopulation? Are you frickin’ kidding me? Do you think plants, fruits, and vegetables are the only life that can be purposefully, scientifically, and genetically altered from their natural form?

Let’s get more acquainted with the institute celebrating her legacy, shall we?

Embracing a postgenomic era

The Sanger Institute will examine how genomes are implicated in the biology of disease in greater detail, with greater precision and at faster rate than previously thought possible. Genomes are rapidly becoming a part of the essential fabric of biology, rather than an expensive resource.

Our target is to understand the function of genes on a genome-wide scale. The intellectual commitment and drive of our researchers, combined with developments in technology, will allow us to make a contribution to the understanding of how genes work that is as significant as our contribution to the Human Genome Project.

This contribution will be founded in efforts to tackle the basis of common genetic and infectious disease and to build resources and tools that will help others to tackle disease. Our dual role, as researcher and resource provider, has served biology well and we believe it will become more valuable in the future.

In the next two years, we will sequence more than 1000 human genomes. By 2012, we will make stem cells in more than 10,000 genes.

Human genetics

Our research in Human Genetics will harness the power of our improving sequencing and genotyping infrastructure in order to gain a better understanding of the diversity of the human species and how this diversity influences our health and disease. By 2011, the Institute will have sequenced more than 1000 human genomes. As part of the Wellcome Trust Case Control Consortium and other similar large-scale consortia, we will continue to discover important genetic variants on the scale that is required to give insight into the genetics of common disease.

By 2013, the International Cancer Genome Consortium will have produced comprehensive catalogues of mutations in more than 50 different tumour types. This work, in which we play a leading role, will lay the foundation for clinical research to produce treatments that could help to reduce the global cancer burden.

Building on new technologies, we will help to develop a rapidly growing understanding of diseases including cancer, heart disease and diabetes. Our research outputs and resources, such as the DECIPHER database, will move into clinical practice as our biological understanding becomes clinically essential.

Infectious disease

Our capacity to analyse genomes means that we can examine the diversity of pathogens, both within and between species, on a scale unmatched within Europe. Our future research will lead to new understanding of infectious disease and its development and spread: using new technologies we can map individual organisms and the development of disease in an individual or among a population with exquisite accuracy. Embracing these technologies, our researchers will complete a staggering 10,000 pathogen sequences by 2011.

We will move rapidly to examining the interactions between pathogen and host a vital meeting point that influences the genetics of both organisms. Our research in malaria will strengthen understanding of genetics of host-pathogen interactions. Our programmes will help to build capacity among researchers in the UK and in front-line countries facing the challenge of infectious disease. Our research into malaria shares the Global Malaria Action Plan’s morbidity reduction targets for 2010 and 2015.

Our research in pathogens will also build on the MRSA and C. difficile sequences in order to help health authorities make rational and considered plans for dealing with healthcare-associated infections.

Model organisms

Working with our collaborators, we will deliver, over the next few years, resources that will transform research using model organisms.

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Mice are used as a model organism.

Cloning of genetically created mice justifies total abuse of life, for the
life is created by man and therefore owned by man. How long before
humans are treated merely as model organisms used as resources?

Oops! Too late…

–=–

 

These remarkable resources notwithstanding, it is our research programmes that hold increasing promise.

Our research in the mouse will give a biological understanding of the genes implicated in cancer found through other programmes, such as the International Cancer Genome Consortium. Using mouse models, we will identify and unlock the networks of genes that drive cancer.

We will develop systems to accelerate stem cell research by allowing better manipulation of cell lines and by enhancing the production of embryonic stem (ES) cells.

The resources will support new research in developmental biology, hearing and cognition.

Source–> http://www.sanger.ac.uk/about/what/future.html

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You might say that mice are the gateway drug to human resource cloning as model organisms. For if we don’t protect that which cannot protect itself, then perhaps we deserve a similar fate.

To view this disturbing mouse resource collection, go here:

Community

The Institute is a leading contributor to the European Conditional Mouse Mutagenesis Program (EUCOMM), the NIH-funded Knockout mouse programmes of KOMP and KOMP2, the International Knockout Mouse Consortium (IKMC), and the International Mouse Phenotyping Consortium (IMPC).

We have generated BACs for various mouse strains that are displayed on the Mouse Resources Portal and Ensembl and are available from Source BioScienceLifeSciences and the BACPAC Resources Center. Mouse ES cells are available from MMRC UC Davis.

Data generated at the Sanger Institute is available from our from the Mouse Genomes Project.

Source–> http://www.sanger.ac.uk/resources/mouse/

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Now, those in their right mind should be very concerned with the potential of this type of power. This is like children getting ahold of God’s constructor set and becoming little creators of hell on Earth. This is not just power, but the absolute power of negative creation, undoing the natural mathematical order of the DNA of all things.

But then, no body seems to be in their right mind when considering this. For man is patenting his creation as he goes, using word magic to be the master of life itself…

(CNN) — Here’s a little-known fact: Under current law, it’s possible to hold a patent on a piece of human DNA, otherwise known as a gene.

Some breast cancers… are linked with the genes BRCA1 and BRCA2.

Companies that have acquired patents for genes have specific rights to their use, which may include diagnostic tests based on those genes, as well as future mutations that are discovered.

In a new lawsuit, the American Civil Liberties Union alleges that the policy is unconstitutional.

The targets of the lawsuit, Myriad Genetics and the University of Utah Research Foundation, hold patents to BRCA1 and BRCA2, the genes responsible for many cases of hereditary breast and ovarian cancers.

The U.S. Patent and Trademark Office is also named in the suit.

The lawsuit asserts that the patents prevent some people from accessing medical screening for BRCA1 and BRCA2. It also challenges the general patentability of genes, which has been legal since 1980. That year, in Diamond v. Chakrabarty, the Supreme Court found in favor of Ananda Mohan Chakrabarty, who used bacteria to engineer a microbe that dissolves oil.  Watch Dr. Gupta explain the lawsuit »

Genes form the basic unit of heredity. With modern technology, researchers have determined that particular genes carry an associated risk of illness.

A striking 20 percent of all human genes have been patented. However, now that all 20,000 to 25,000 human genes have been mapped and sequenced through the Human Genome Project, they are in the public domain, meaning they would no longer be considered “new” for the purposes of patents, said Lee Silver, professor of molecular biology and public policy at Princeton University. Now, patents on human genes must specify a new use, such as a diagnostic test.

If a company wants to patent the purified form of an antibiotic that exists in nature in a fungus, no one challenges that, Silver said. Plant DNA, as well as human DNA, can be synthesized in a laboratory. Distinguishing this case from a patented human gene that is useful in diagnostics would require the ethical argument that the human genome is sacred — and even then, things get murky, considering that about 25 percent of human genes are shared by chimpanzees, he said.

THE PATENT LAW SAYS NOTHING ABOUT ETHICS,” he said…

Source–> http://www.cnn.com/2009/HEALTH/05/13/genes.patent.myriad/index.html?_s=PM:HEALTH

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Again, it is said that power corrupts, and absolute power corrupts absolutely.

So, in reference to this notion of power, what would you consider on a scale of 1-10 the power-base of knowledge in being able to control the entire expression of the human genome within the entire population of Earth – real or synthetic? Would you say that it is a 10 on that scale perhaps if one could wipe out the expression for empathy and religious capacity? How about the expression for logical thinking and reason… would that be a corruption of power? And what about love…?

What about synthetic people, or clones? Who needs the real thing when you can hand deliver the perfect, docile, subservient beast of a patented human?

From its website, the Sanger Institute explains it’s purpose:

What we do

Our research at the Wellcome Trust Sanger Institute builds understanding of gene function in health and disease as well as creating resources of lasting value to biomedical research.

We study diseases that have an impact on health globally by investigating genomes. Building on our past achievements and based on priorities that exploit the unique expertise of our Faculty of researchers, we will lead global efforts to understand the biology of genomes. We are convinced of the importance of making this research available and accessible for all audiences

Our research into genetics and disease

Our genomic information has a significant impact on our health. Global health problems including cancer, malaria, diabetes, obesity and infectious disease are partially determined genetically. At the Sanger Institute we are uniquely placed to build on genome sequences and to engage in biomedical research that elucidates the genetic basis of such common diseases as well as rare or neglected diseases.

Why we study genomes

Genomes are the archival instructions upon which an organism is built. The sequence data provided by the Human Genome Project is a rich source of information that drives improved understanding of human health and variation. Studying human sequences, comparing model organism genomes and investigating the effects of pathogens on humans will build knowledge of the diversity of our genomes and how this affects our susceptibility to disease

Source–> http://www.sanger.ac.uk/about/what/

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From its annual review, we read:

Genomes continue to revolutionise the study of biology. Their contribution to medicine is just kicking off.

In 2011 our sequencing pipeline delivered 200,000,000,000,000 (200 trillion) bases of DNAmore than all the previous years of the Institute combined.

Coupled with the output from our genotyping pipeline, which is using the latest DNA chip technology, our researchers are able to interrogate genomes at a scale and resolution that is many orders of magnitude greater than before. This rich vein of information is enabling our researchers to discover and interpret at ever greater depth the significance of genomic variation within and between species.

Drawing on our vast genomic resources enables us to play a leading role in national and international collaborations. The techniques, databases and software we develop allow us to make vital contributions to research into the spread of infectious disease, the development of cancer, and the epidemiology of malaria, sickle cell disease and metabolic risk factors in Africa.

Our ability to answer new questions is turning received genomic understanding on its head. For example, when the Cancer Genome Project team investigated structural DNA rearrangements in the chromosomes in cancer, they uncovered an entirely new mechanism for cancer development. The team discovered that some people’s cancer genomes bore the scars of a catastrophic event that had driven them a number of steps towards cancer in a single cell cycle. The chromosomes had exploded and incorrect pasting together of the DNA had produced many cancer-driving mutations.

Another convention-busting discovery was made when our researchers sought to complete the genomic picture of the spectrum of Leishmania parasites. Seeking to understand the genomic variations responsible for the differing severity of symptoms caused by the different strains, the team made a surprising discovery. Producing high-quality reference genome sequences showed that the different strains had almost identical genetic codes, but that the strains’ genomes contained different numbers of copies of the chromosomes. This finding suggests that the parasite’s evolutionary development and success is founded on the numbers of particular genes and chromosomes it has – a genetic abnormality that would kill most organisms.

Our Pathogens teams are harnessing our high-throughput sequencing and analysis resources to compare variation between individual bacterial and viral genomes from patients to track and trace precisely the spread of disease. By comparing cholera genomes during the current global pandemic, our researchers have been able to categorically trace its origin back to the Bay of Bengal. Using the same technique, we have mapped the spread of the H1N1 flu virus across the UK during the most recent epidemic and have shown that the disease entered at a number of geographic locations at different times, before the first clinical case was identified.

Our ability to conduct genomic research at high resolution and vast scope enables us to provide the foundations for the global research community to build upon. For example, the fruits of our investment in the 1000 Genomes Project are being harvested by researchers across the globe as they use the data to enhance the resolution of the genome-wide association studies and understand the origins of genetic mutation

Source–> http://www.sanger.ac.uk/about/how/assets/2011wtsi_annual_review_full.pdf

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Open source genetic codes for genomes?

Instructional genomic blueprints for cancer offered to the world?

Offering the entire mechanism for the spread of disease on the cellular level to the militaries (governments) of the world?

Sharing the origins of genetic mutation with anyone interested?

20 trillion base DNA sets deconstructed in a single year?

Perhaps my concern is not being completely burned into the readers conscious here, and perhaps that’s because the reader may not be reading this from the point of view of a racially driven, psychopathic purist de-populationist! Get it? The “Sanger” institute? In honor of dear old Margaret? This should make even the roots of your own DNA shake violently with fear and loathing. Satan, if you believe in that sort of thing, could not ask for a better tool as the defined “adversary of man,” with this toolset being the epitome of the model chemistry set to de-construct nature and reform it in man’s own image. This new world order of DNA and genomic expression belongs in no mans hands, for no man is immune from the ultimate disease of unrestrained power. There are no true ethics in the modern notion of what is “science,” because the institution of science today specifically disregards nature’s (God’s) design in order to exploit and alter the intent of that self-evident design. It studies nature only in order to change or destroy it. The diseases it is claiming to be able to treat and cure on the genetic level were of course caused by this very same institution of medical and scientific crimes against man and nature in the first place, and so the placing of our faith in such institutions to cure us from its own self-inflicted ills is fool-hearted at best. Cancer was all but non-existant before modern practices of those who profess to be professors, professionals, scientists, and doctors spread it experimentally as vaccine ingredients, rearing its ugly head according to some in history only after modern vaccination was introduced.

And that brings me to my point. We have all been stung by this beast of medical science. Vaccination is designed to apparently replace what nature has already installed within the expressions of the body as the natural immune response to outside influences. One has no allergy to bee stings, for instance, unless one is stung by the bee, which delivers its disease-causing agents through a stinging injection. Spiders penetrate by a stinging bite, as do dogs with rabies. Tetanus and hepatitis thrive many places, but can only enter the body through a stinging penetration of the skin (or through the penetration of intercourse, i.e. the exchange of bodily fluids). The vaccination needle is the simulated, weaponized sexual appendage of the science of modern medicine. We are violated by it, raped by it; we are injected (stung) with substances and DNA that would never otherwise have the capacity to enter our bodies and mix with our substance. We are literally being grafted like fruit trees with the foundational building blocks of the gene expression and DNA of other life forms, including that of our fellow man as with the injection of cloned human diploid cells (including DNA and proteins) from various aborted fetal tissues, human albumin (from blood), rhesus monkey fetal lung cells, continuous (cloned) line of monkey kidney cells, rhesus monkey fetal diploid cells, simian cancer virus-40 (and at least 79 others), vesicle fluid from calf skins, calf serum, bovine serum, bovine fetal serum, U.S. sourced bovine extract, washed sheep red blood cells (RBC’s), chick embryo, chick embryonic fluid, chicken protein, mouse serum proteins, guinea pig embryo cells, shark squalene, gelatin, hydrolized gelatin, processed gelatin, lactose, and others. These are just a few of the ingredients that you have been infected with by stingers called needles.

Vaccination is, in its most simple description, the purposeful infection of the body with foreign particles and substances. Whether those substances are good or bad, beneficial or harmful, therapeutic or deadly does not remove the fact that vaccination is nothing more than purposeful infection with disease. This is not contagion, for a vaccinated person is not necessarily contagious, though some “shedding” of the vaccine does take place after infection (vaccination). The injection of peanut oils and lactose as ingredients in vaccines, for instance, is certainly linked to localized milk and peanut allergies that are not spreadable as contagious infection to others, but are rather local reactions to otherwise harmless foods, if only they were eaten instead of injected past any natural barriers. Thus, we must think outside of the box we are placed into by media education and realize that infection is a neutral word that actually also represents any forcing of so-called “medicine” into the body.

But consider how the body then might react to monkey kidney tissue or cow blood being injected into it, bypassing the natural protective barriers for such agents through the deep, penetrating sting of the inoculation needle. It is well known that even the Rh factor of some human blood types prevents negative and positive bloods from mixing to create life. The mother’s body will literally attack the newly formed embryo of a different blood type (Rh) to kill it as a foreign infection. So imagine how incompatible your body and its blood and fluid is to cow, monkey, pig, sheep, insect, and other animal blood and protein products used in vaccines, which have no other way to enter and infect your body but through the penetrating sting of vaccination.

But let’s not stop there. For other ingredients within vaccines also have no hope of forcibly entering past your body’s defenses without the sting of a nurse or pharmacy technician with a couple of weeks of government sponsered training and indoctrination mixed with a healthy dose of cognitive dissonance. The arrogant advocate for vaccination is always one who’s livelihood depends on delivering it, no differently than those animals and insects that sting or bite in protection of their own livelihood… or to spread parasites. And the propaganda machine of fallacy and quack science fills the heads of those who subject themselves and their own children to such violations of the natural law as vaccines are.

Let’s not forget the heavy metals and other extra ingredients also used in vaccines with thinly veiled reasonings and names such as preservatives and adjuvents. Those include such other foreign particles and poisons (medicines) as formaldehyde, aluminum hydroxide, aluminum phosphate, thimerosal (mercury-based), polysorbate 80 (Tween-80), ammonium sulfate, formalin, sucrose, sorbitol, benzethonium chloride, glycerin, phenol (a compound obtained by distillation of coal tar), beta-propiolactone, 2-phenoxyethanol, polysorbate 20, yeast, chemically defined yeast-based medium, soy protein, phenol red indicator, phosphate buffered saline, monosodium L-glutamate (MSG), potassium glutamate, potassium chloride, potassium phosphate monobasic, potassium phosphate dibasic, potassium monophosphate, potassium diphosphate, sodium bicarbonate, sodium phosphate dibasic, polydimethylsiloxane (silicone), and even the known cancer causing agent aspartame.

It is therefore likely that in yours, and especially in your child’s lifetime, most or all of these listed vaccine ingredients have been injected into your body, along with the various disease causing microbes, antibiotics (anti-life), and other ingredients not listed here. And your body reacts to every one of these ingredients, either in the short or long term as the manifestation of chronic disease states. I can think of nothing else to call this but sheer insanity. The blanket acceptance of the “science” of vaccination in my mind can only be attributed to two things. Ignorance is certinaly a fine-tuned and well oiled machine within the general population. But can we really blame sheer ignorance? What about custom, routine, greed, profits, and medical advice?

But what if there is another factor at play here? What if there is another unseen force that is driving people to promote and commit to actions like vaccination, eating junk food as their main staple, taking pharmaceutical drugs that will knowingly cause more severe disease than what they will treat, and submitting themselves to the unspeakable atrocities of modern and cosmetic medicine – which is by the way the leading cause by far of death in the world, called “iatrogenic” death, or death by medicine/doctor.

Is it possible that mankind could be driven subconsciously by another infective force more powerful than ignorance, more persuasive than propaganda, and more controlling than hypnosis?

And if this possibility may indeed be the case, would man even know he was infected?

This is the theory I’d like to explore herein…

–=–
The Parasite Lives By Control
And Knows No Other Path

–=–

I ask you now to become a neutral.

As I postulated in the opening of this thesis, I believe that any reader of this work may have only gotten this far due to their uninfected empathy and therefore unvaccinated desire to learn the answers to questions that cannot seem to be answered by merely considering what is known or by what is normal or natural. And so the question to the answer we seek may very well sit in the world of the unseen, and may therefore be hidden in the unknown. For the purely logical thinker, who needs proof of claim to every aspect of reality, I can only try my best to qualify the facts presented herein, for I cannot show you the unseeable. I have not the tools to make proof, and so I cannot prove the unprovable. And so I ask your forgiveness in this regard, and ask that you clear your mind of what you think you know so that your limiting perceptions of reality don’t get in your own way. Yet at the same time, I wish to invoke in you your use of the logic machine, the Trivium, and to examine what I present here with the goal not of belief or disbelief, but with the desire to prove or disprove – what the scientific method once also was designed to do instead of genetically altering everything so as to create falsely created evidence of a genetically altered reality.

The question I propose to answer here to the best of my rational ability is simply this:

Can the actions and inactions for which most of mankind are exhibiting in acting against its own best interest be attributed to a parasitic infection of his brain and DNA? 

First, let’s place on the exhibit table the evidence of these actions of man against his own interest.

1) Geoengineering. It is being taught in universities around the world now. It is highly regulated in the codes and statutes of government, permits are required, and international treaties are law regarding its use in war and in peacetime. It is no longer a theory, but a certified and provable current practice. In other words, it is a provable conspiracy (plan between two or more people) to significantly and purposefully alter the environment, and is a highly protected industry by governments around the world, including the United Nations. If this fact is not readily apparent to the reader, then please see the links below. For those who can see it happening in the sky above them, again I can only assume according to my presented theory here that you are not parasitically restricted from recognition and comprehension of these strange happenings. Geoengeneering though, as defined and taught in the University system, is not merely the alteration of the air and atmosphere. It is the alteration of the land and oceans as well. For more factual information on this, please see my sourced research here:

https://realitybloger.wordpress.com/2014/05/11/degrees-in-geo-engineering-and-sustainable-development/

https://realitybloger.wordpress.com/2011/11/25/geoengineering-and-cloud-seeding/

https://realitybloger.wordpress.com/2013/03/16/the-only-way-we-can-stop-geoengineering/

https://realitybloger.wordpress.com/2012/08/25/research-tips/

https://realitybloger.wordpress.com/2013/10/15/weather-modification-in-utah-begins-today/

2) Species Die Offs. As we sit back and watch with a helpless feeling and a bag of Funyons, we are digitally presented with facts and figures that the surface life on planet Earth, on both the land and in the ocean, is dying. We are shown images and videos of mass schools of dead fish washed up on shores or in harbors, of hundreds of birds falling dead from the sky mid-flight, and of statistical realities of millions of species of plants, animals, and insects becoming extinct. Is it at all strange to think that this may be directly correlated with the actions of man, if as above we can see that the organized actions of man are literally altering the entire biosphere of the planet on a global scale through quite purposeful Geoengineering? Where is the logic, the empathy, and the calvary, for we cannot live without the rest of nature? That is, unless man and nature are being fundamentally altered and with genomic precision reconstituted at the cellular level to survive as hosts within such a dystopia as is apparently being created by what is seemingly, if you will, men who may very well be parasitically infected and controlled at the cellular level. And so the question may no longer be who is causing the problems, but what is infecting the brains of the men who are causing these problems?

3) Natural Healthy Foods Are Being Outlawed. “Codex Alimentarius Austriacus,” is a collection of standards and product descriptions for a wide variety of foods developed In the Austrian-Hungarian Empire between 1897 and 1911 as a voluntary effort between “experts” in the food industry and in universities. Though used in legal proceedings for identity and standards purposes, this collection is not legally enforceable. However, the bastardization of this effort was created into what is today known as the international Codex Alimentarius Commission, part of the Food and Agricultural Organization and the World Health Organization of the United Nations, which is employed as the international food codex, or “law.” This integration as a legal overlord of food took place in Austrian law in 1975. The council was created in 1958 under the joint sponsorship of the International Commission on Agricultural Industries and the International Bureau of Analytical Chemistry. And you wonder why the ingredient list on your cereal box looks like a chemistry experiment? Today, Codex Alimentarius (Latin for “Book of Food”) is a collection of internationally recognized standards, codes of practice, guidelines and other recommendations relating to what is food, production of that food, and what is considered safe as food. Food is one of those things in nature that are, well, pretty damn self-evident. And while it’s probably a good thing to know enough about nature to eat from it without being poisoned, the extent of what is now being labeled as “food” and “food ingredients” defies all possible logic… unless of course the parasitic infection of man is taken into consideration!!! Simply stated, if a parasite were hungry for the nutrient diet it needs to survive, it is logical and provable in nature that the parasite would control the actions of its host in order to cause the man or other host to “infect” itself with “food stuffs” that are in actuality harmful, poisonous, and even fatal to the man but promotive of the parasite. Inversely, it would be a logical conclusion to assume that the parasite would do anything within its power to cause the man to cease to ingest anything that might harm the parasite that would otherwise be beneficial to the man, especially those food stuffs that would kill or prevent the growth and viability of parasites. Therefore, the reasonable conclusion to be made if indeed mankind is suffering from an ancient, highly advanced, parasitic intelligence that controls man’s will would be to assume that those men who organize to write laws, alter the environment, and promote or ban certain food stuffs and ingredients would be the ones being controlled by said parasites so as to act against the best interests of man and nature while at the same time promoting the best interests of the parasite. The host only lives to serve the parasite, as far as the parasite is concerned. This is evident all throughout nature, which we will explore the evidence of in depth later in this essay. And so the answer to one of the many questions the reader may be seeking as to ascertain what the hell is happening in the world may rely on the readers ability to contemplate this theory. Why are foods being re-engineered and genetically altered? Why are they being changed in a way that provably causes such harm to man and nature while men in high authority positions pass laws to protect these genetic alterations? If these men are indeed parasitically controlled, then the answer to these questions is quite clear. And this even answers what seemed before to be the great unanswerable preponderance of all who are asking such questions… Why are they knowingly causing harm to their own environment? Don’t they have to live here too? What about their children’s future? Here again the only truly logical answer is parasitic infection. Some may call them psychopaths. But what if they simply have no capability to act in anyone’s best interest but their own, which is now only in the best interest of the parasite controlling their actions? To give a few examples of this subversion of foods that might harm the parasite, we can think back to the half century mark when propaganda was just starting to take flight. Butter, animal fats, and other staples of diets around the world were suddenly being demonized. Soon, synthetic food products like margarine, American cheese, and shortening were being advertised as replacements for fats. What the reader might not know is that cholesterol, that is to say what was demonized as “bad cholesterol,” is listed in many government sponsored research studies as being the essential ingredient in expelling pathogens from the body. No cholesterol means that disease may flourish. Other examples are Cannabis Sativa, which has properties shown to prevent and destroy diseases like cancer. We are currently experiencing the total genetic alteration of this miracle plant by companies like Monsanto seeking to genetically alter it so as to patent and control its use. The therapeutic uses, therefore, are being bred out of the plant and who knows what is being bred into it. Both marijuana and cholesterol are proven to prevent the spread of prion disease, but only in their natural form. Genetically altered stains will be useless for medical purposes, just as margarine is. Though countless examples persist, where the alteration or banning of foods, spices, seeds, and plants that are extremely healthy and more importantly can cure disease, are outrightly being replaced with synthetics, most of us in our right mind cannot even come close to creating a good reason why this is taking place against humanities best interests. And yet, here again, parasitic infection of the minds of those participating in this “food science” is in fact the only plausible answer. Not greed, not profits, and not ignorance. It seems no other plausible reason exists!

4. Unprecedented Technological Advancement. In 1946, ENIAC (Electronic Numerical Integrator and Computer) was unveiled as the supposed first true all-purpose electronic computer. Weighing in at 30 tons, the size of two semis, and consisting of 19,000 vacuum tubes, 6,000 switches, and requiring many human attendants to answer to incredible amounts of blinking lights. It had the capability in unheard of marvel to add 5,000 numbers in a single second! And it could predict through this powerful computation the trajectory of an artillery shell before it landed. Naturally it was government (military) funded! Just 20 years later, “the hand-held pocket calculator was invented at Texas Instruments, Incorporated (TI) in 1966, following their invention of the first integrated circuit in 1958, subsequently patented in 1964. In 1974, the miniature electronic calculator came into being along with the Texas Instruments’  patent for personal-sized, battery-operated calculators using a single integrated semiconductor circuit array or “one-chip” calculators. 12 years later, in 1986, calculators still represented an estimated 41% of the world’s general-purpose hardware capacity to compute information. Flashing forward only 21 years to 2007, calculators had reportedly been replaced by personal computers to the point that calculator use diminished to less than 0.05% use by 2007. And here we are today, with the 30 ounce computer replacing the 30 ton ENIAC in less than 70 years. Let’s compare that to the invention of the light bulb. In 1801, British inventor Humphry Davy invented an incandescent light bulb, and later created the “arc lamp” in 1809. Though many similar inventions were created over the years, it was not until 1880 (79 years later) that Joseph Wilson Swan became the first man with a house lit by a lightbulb at the same time Edison was plagiarizing his own patents for profit of what should be free energy. 78 years… And yet in today’s high tech world we are seeing technology double every few months or years. Many theories have been attributed to this impossible race of technological breakthroughs, including the reverse engineering of alien technology and even aliens themselves doing the work. But what if the aliens were merely parasites? What if the question is not which man is inventing things today so rapidly in succession, but instead we should be asking how is such sudden knowledge possible? Is it ancient knowledge? Is it parasitic infection that is driving the intent of men to create nuclear bombs, biological weapons, Geoengineering designs, genomic subversion and mapping, and the host of other inventions that go so far against nature and the self-interest of mankind that no other explanation makes any logical sense? In one year, 200 trillion bases of DNA catalogued… which was more than all previous years put together. Does that seem reasonable to you? Does anything our leaders and organizations or corporations are doing today seem reasonable or logical to you? Have you ever talked to anyone who is capable of inventing such super-advanced technology, or just the people who put the parts together and operate the machinery? Do they really know how it works? Could they re-create the technology that machines are programed to produce and manufacture today, or are they just worker bees for the parasite hive-mind? And let’s not forget to mention the strange advent of transhumanism, i.e. the genetic alteration of humans to interface with machines or synthetic biologic technologies.

While other examples could be looked at, perhaps it is time to explain just where I could possibly have gotten this strange notion from.

–=–

Meet The Family: Toxoplasmosis Rules!

–=–

This is a fascinating look into cross-species protozoan parasitic infection, which literally makes a rat act against its best interest (its own life) by making it sexually attracted to it’s most deadly enemy. It gives rewards for stupid behavior. And this parasite purposefully infects the rat just to get itself into the cat’s stomach after it eats the rat.

When toxoplasmosis infects the human brain, it also seems to create feelings of sexual reward and pleasure through dopamine production for dangerous behavior. In other words, the human is rewarded for acting against his or her best interest.

What does the government say about this?

From the CDC website we read:

Toxoplasmosis is considered to be a leading cause of death attributed to foodborne illness in the United States. More than 60 million men, women, and children in the U.S. carry the Toxoplasma parasite, but very few have symptoms because the immune system usually keeps the parasite from causing illness.

However, women newly infected with Toxoplasma during pregnancy and anyone with a compromised immune system should be aware that toxoplasmosis can have severe consequences.

Toxoplasmosis is considered one of the Neglected Parasitic Infections, a group of five parasitic diseases that have been targeted by CDC for public health action.

Source–> http://www.cdc.gov/parasites/toxoplasmosis/index.html

–=–

Keep in mind that science of vaccines and the various frequency generators in our modern conveniences specifically weakens the immune system, as do many pharmaceutical drugs.

The International Scientific Times reports:

Scientists say that the Toxoplasma gondii parasite, or Toxo for short, living in 40 percent of our brains affects our sense of fear and risk-taking. Researchers found that rats, with which humans share a number of characteristics with, infected with the Toxo parasite were attracted to the smell of cat urine, instead of being afraid of it.

“Pathways that normally responded to the smell of cat urine with alarm had been damped down, while the pleasure hormone dopamine, normally released in response to female rodent urine, was now triggered by the whiff of cat,” The Telegraph reports. Scientists say it’s all part of the parasite’s way of spreading from host to host – rats that aren’t afraid of cats are more likely to be eaten by them, thereby spreading the parasite to the cat.

In human studies, the findings were similarly alarming. While men infected with the parasite were more likely to become introverted and dress down, infected women behaved just the opposite dressing up and acting more sociable. The more likely a person is to interact with others, the better chances the parasite has of passing itself on.

Joanne Webster, professor of parasite epidemiology at Imperial College London, told The Telegraph that parasites prefer the brain because it is removed from the body’s immune system and also because it gives them “direct access” to the mechanisms of behavior.

We’ve known about the Toxo parasite since the 1920s, when scientists learned that the parasite was present in the feces of cats. During the AIDS epidemic, before antiretroviral drugs were effective and more widely available, the Toxo parasite was blamed for the dementia that many AIDS patients experienced towards the end of their lives.

The idea that parasites could control human behavior was first investigated in the early 1990s by an evolutionary biologist at Charles University in Prague named Jaroslav Flegr.

There is strong psychological resistance to the possibility that human behavior can be influenced by some stupid parasite,” Flegr told the The Atlantic in March 2012.

He said he first learned of the ability of parasites to control their hosts 30 years ago after reading about how a certain flatworm can control ants by taking over their nervous systems. “It was the first I learned about this kind of manipulation, so it made a big impression on me,” Flegr said.

Source–> http://www.isciencetimes.com/articles/4792/20130328/toxoplasma-gondii-brain-parasite-40-percent-infected.htm

–=–

brainworms
A human brain overrun with cysts from Taenia solium, a tapeworm that normally inhabits the muscles of pigs.

Gee… how could a pig parasite have gotten past the blood brain barrier unless it was injected?

–=–

“In terms of numbers, there are more parasitic infections
acquired in this country (United States) than in Africa.”

– Dr Frank Nova, NIH Parasitic Diseases Lab Chief

–=–

A recent issue of National Geographic came with the shocking cover story named “Real Zombies: The Strange Science of the Living Dead.”

Naturally, I was intrigued. And when I read the story, my worse fears were suddenly manifest, as it revealed some of the worst possible parasite infections in nature.

Perhaps the most shocking display of the designs that can be willed by the parasite to the host is this one:

“In Costa Rica, the orb-weaving spider Leucauge argyra will go to extravagant lengths to accommodate the needs of Hymenoepimecis argyraphaga, another freeloading wasp. The female glues its egg to the host’s body. After the larva emerges, it pokes a few holes in the spider’s abdomen and sucks its blood. When the larva has grown to full size, in a couple of weeks, the spider takes it upon itself to rip down its own web and build a new one of a radically different shape. Instead of a multistranded net designed for catching flying insects, the new web is merely a few thick cables converging at a central point. Having sucked its host dry, the larva spins its cocoon on a thread hanging from the intersection of the cables. Suspended in the air, the cocoon is nearly impossible for would-be predators to reach.”

Considering this dramatic takeover of the mind, where the spider is literally stripped of its natural instincts of survival in order to protect its unwelcome parasitic guest and thus mind-controlled to be made to demolish its own web, is it at all unreasonable to assume that this may be happening in the human population as well, which is observably and virtually doing just about the same thing?

Other documented cases include:

“A fly that infects bumblebees causes them to burrow into the ground in autumn, right before the fly emerges to form a pupa. In the ground the fly is protected not only from predators but also from the cold of winter.”

“Killifish, for example, normally stay away from the surface of the water to avoid being picked off by wading birds. But when they’re infected with flatworms known as flukes, they spend more time near the surface and sometimes roll so that their silvery bellies glint in the light. Infected killifish are far more likely to be picked off than healthy ones. And it just so happens that the gut of a bird is where the flukes need to go next to mature and reproduce.”

“Before infecting a human host, Plasmodium, the protozoan that causes malaria, spends the first stages of its life cycle in a mosquito. The mosquito needs to drink blood to survive. But this behavior poses a risk to the protozoan, because the mosquito may be crushed by the hand of an annoyed human victim, eliminating the opportunity forPlasmodium to move to the next stage of its life cycle, in the human. To reduce this risk while it is still developing in the mosquito, Plasmodium makes its host blood shy, seeking fewer victims each night and giving up faster if it can’t find a gusher of blood. Once Plasmodium has matured and is ready to enter a human host, it manipulates the mosquito’s behavior in the opposite direction. Now the mosquito grows thirsty and foolhardy, seeking out more humans each night and biting repeatedly even if it is already full. If the mosquito dies at the hand of a human, it is no longer of any consequence. Plasmodium has moved on.”

“Frederic Libersat of Ben-Gurion University and his colleagues, for example, are dissecting the sinister attacks of the jewel wasp, Ampulex compressa. The wasp stings a cockroach, transforming it into a passive zombie. The wasp can then walk its drugged victim into a burrow by the roach’s antenna, like a dog on a leash. The roach is perfectly capable of movement. It just lacks any motivation to move on its own behalf. The wasp lays an egg on the roach’s underside, and the roach simply stands there as the wasp larva emerges from the egg and digs into its abdomen. What is the secret hold that the wasp has over its victim? Libersat and his colleagues have found that the wasp delicately snakes its stinger into the roach’s brain, sensing its way to the regions that initiate movements. The wasp douses the neurons with a cocktail of neurotransmitters, which work like psychoactive drugs. Libersat’s experiments suggest that they tamp down the activity of neurons that normally respond to danger by prompting the cockroach to escape.”

“Baculoviruses, for example, infect the caterpillars of gypsy moths and a number of other species of moths and butterflies. The parasite invades its host’s cells, hijacking them to make new baculoviruses. On the outside the caterpillar appears normal, continuing to munch on leaves as before. But the food it eats is not becoming more caterpillar tissue. Instead it’s becoming more baculoviruses. When the virus is ready to leave its host, the caterpillars undergo a radical change. They become agitated, feeding without rest. And then they begin to climb. Instead of stopping in safe spots out of the way of predators, the infected caterpillars creep higher into the trees, remaining on top of leaves or on tree bark in daylight hours, when they are easily seen by predators. The baculoviruses carry genes for several enzymes. When they’re ready to leave their host, certain genes become active in caterpillar cells, producing a torrent of enzymes that dissolve the animal into goo. As the caterpillars dissolve, clumps of viruses shower down onto the leaves below, to be ingested by new caterpillar hosts. To Kelli Hoover and David Hughes of Penn State University and their colleagues, the climbing behavior of the caterpillars seemed like an exquisite example of an extended phenotype. By causing their hosts to move up in trees, the baculoviruses increased their chances of infecting a new host down below. To test Dawkins’s idea, they examined the genes in baculoviruses, to see if they could find one that controlled the climbing of caterpillars. When the researchers shut down a single gene in the virus, called egt, it continued to infect caterpillar cells and replicate as before, even turning the caterpillars to goo as before. But baculoviruses without a working copy of egt could not cause the caterpillars to climb trees. It’s unlikely that many other parasites control their hosts with a single gene; an animal’s behavior is typically influenced by a number of its own genes, each contributing a small part to the sum. So it’s probable that many parasites control their hosts with a multitude of their own genes.”

“And what of D. coccinellae and its hapless ladybug host? While at the University of Montreal, Fanny Maure and her colleagues made a startling discovery: In turning its victim into a willing bodyguard, the wasp itself may only be acting as the extended phenotype of yet another organism. The researchers found that when a wasp injects an egg into a ladybug victim, she also injects a cocktail of chemicals and other substancesincluding a virus that replicates in the wasp’s ovaries. Some evidence suggests it is this virus that immobilizes the ladybug, protecting the wasp’s cocoon from intruders. The virus and the wasp have the same evolutionary interests; turning a ladybug into a bodyguard produces more wasps, and more wasps beget more viruses. And so their genes work together to make the ladybug their puppet. The D. coccinellae wasp may not be the puppet master it once seemed. Instead it hides another puppet master within.”

Source–> http://ngm.nationalgeographic.com/2014/11/mindsuckers/zimmer-text

–=–

Now you tell me that this wasps sting and payload as read above is not the exact description of the vaccination process!!! The wasp injects… a cocktail of chemicals and other substances…

And what could be a more sympathetic project for parasites that control their victims through gene expression than that of the Epigenome and Genome Projects?

Oh the joys of what can be created with genetic sequencing and vaccination of its result.

The author of this article also speculates that about 80% of ALL LIFE on Earth is in actuality parasitic in nature. 80%!

In our exploration of the horrors of parasitic brainwashing, let us not forget one of the most wonderfully bizarre and frightening parasitic manifestations of strange, anti-self-interest behavior…

–=–

Meet the Cordyceps

–=–

Perhaps the most intriguing aspect of the ant colony in its customary dealings with infected zombie ants due to the obvious manifestation of cordycep infection, is that the ants that are “in their right mind” forcibly quarantine the rest of the ant colony from the infected ant. And so you might want to ask yourself why we are not emulating nature in this regard? Why are we, that is we who are still collectively in our right minds, not at least quarantining ourselves and perhaps organizing to stop our own infected madmen from destroying our colony on Earth?

In 2010, National Geographic published an even more disturbing article and documentary movie on the notion of a real “zombie” infection in the human population:

“Zombie Virus” Possible via Rabies-Flu Hybrid?

Highly improbable genetic tweak could create mutant virus.

In the zombie flicks 28 Days Later and I Am Legend, an unstoppable viral plague sweeps across humanity, transforming people into mindless monsters with cannibalistic tendencies.

Though dead humans can’t come back to life, certain viruses can induce such aggressive, zombie-like behavior, scientists say in the new National Geographic Channel documentary The Truth Behind Zombies, premiering Saturday at 10 p.m. ET/PT. (National Geographic News is part of the National Geographic Society, which part-owns the National Geographic Channel.)

For instance, rabies—a viral disease that infects the central nervous system—can drive people to be violently mad, according to Samita Andreansky, a virologist at the University of Miami’s Miller School of Medicine in Florida who also appears in the documentary.

Combine rabies with the ability of a flu virus to spread quickly through the air, and you might have the makings of a zombie apocalypse.

Rabies Virus Mutation Possible?

Unlike movie zombies, which become reanimated almost immediately after infection, the first signs a human has rabies—such as anxiety, confusion, hallucinations, and paralysisdon’t typically appear for ten days to a year, as the virus incubates inside the body.

Once rabies sets in, though, it’s fatal within a week if left untreated.

If the genetic code of the rabies virus experienced enough changes, or mutations, its incubation time could be reduced dramatically, scientists say.

Many viruses have naturally high mutation rates and constantly change as a means of evading or bypassing the defenses of their hosts.

There are various ways viral mutations can occur, for example through copying mistakes during gene replication or damage from ultraviolet light.

If a rabies virus can mutate fast enough, it could cause infection within an hour or a few hours. That’s entirely plausible,” Andreansky said.

Airborne Rabies Would Create “Rage Virus”

But for the rabies virus to trigger a zombie pandemic like in the movies, it would also have to be much more contagious.

Humans typically catch rabies after being bitten by an infected animal, usually a dog—and the infection usually stops there.

Thanks to pet vaccinations, people rarely contract rabies in the United States today, and even fewer people die from the disease. For example, in 2008 only two cases of human rabies infection were reported to the U.S. Centers for Disease Control and Prevention.

A faster mode of transmission would be through the air, which is how the influenza virus spreads.

“All rabies has to do is go airborne, and you have the rage virus” like in 28 Days Later, Max Mogk, head of the Zombie Research Society, says in the documentary. The international nonprofit is devoted to “raising the level of zombie scholarship in the Arts and Sciences,” according to their website.

To be transmitted by air, rabies would have to “borrow” traits from another virus, such as influenza.

Different forms, or strains, of the same virus can swap pieces of genetic code through processes called reassortment or recombination, said Elankumaran Subbiah, a virologist at Virginia Tech who was not involved in the documentary.

But unrelated viruses simply do not hybridize in nature, Subbiah told National Geographic News.

Likewise, it’s scientifically unheard of for two radically different viruses such as rabies and influenza to borrow traits, he said.

“They’re too different. They cannot share genetic information. Viruses assemble only parts that belong to them, and they don’t mix and match from different families.”

Engineered Zombie Virus Possible?

It’s theoretically possible—though extremely difficult—to create a hybrid rabies-influenza virus using modern genetic-engineering techniques, the University of Miami’s Andreansky said.

“Sure, I could imagine a scenario where you mix rabies with a flu virus to get airborne transmission, a measles virus to get personality changes, the encephalitis virus to cook your brain with fever”—and thus increase aggression even further—”and throw in the ebola virus to cause you to bleed from your guts. Combine all these things, and you’ll [get] something like a zombie virus,” she said.

But [nature] doesn’t allow all of these things to happen at the same time. … You’d most likely get a dead virus.”

Source–> http://news.nationalgeographic.com/news/2010/10/1001027-rabies-influenza-zombie-virus-science/

–=–

Notice that the rule spoken over and over is that “nature” will not allow this type of recombinant mixing to happen. But let’s not forget that science isn’t interested in respecting the limits of nature, but instead seeks to conquer every aspect of it. Recombination happens in the lab, and new recombinations are patented as property of these madmen. Whether this is just human curiosity or parasitic will that is creating the insanity that is the institutional destruction of all that is sacred to man and nature unfortunately cannot be answered here. But the evidence provided here I dare say supports the very possible, even probable theory that this just might be the case.

–=–
The Thing Test
–=–

So what in the hell can we do about this if it is a reality? After all, we can’t see them if they are indeed controlling a portion of humanity.

The real question is whether an infected human would voluntarily be able to submit him or herself to any test conceived to find out! After all, such a test would be against the best interest of the parasite, and the expression of this will to stay hidden would probably be transferred to the personality of the host.

In John Carpenter’s “The Thing,” where the stranded victims could not tell who was the parasite and who was the human, they developed a test which burned the blood samples of each subject. When the parasitic blood was burned, the reaction gave evidence of infection.

–=–

So could such a test be used to detect those who are either infected or not infected?

Before I go all science fiction on you, I’d like to explore another avenue of control that may be explained by this parasitic infection of humanity. That is the notion of harmonic resonance and the spectrum of frequency.

One of the most tightly regulated areas in the world are the airwaves. The control and tuning of broadcast and other frequency is so governed and policed that the penalty for using the air without strict guidelines and permission from the state is harsh to say the least. I have often speculated, considering the history of Royal Rife, Tesla, and other researchers into the power of frequency to both heal and destroy life, including parasites, that the reasons for the “standards and practices” in broadcasting may very well be friendly to a parasitic infection, which would be in control of the regulators. With the advent of localized smart meters, cell phones, and other frequency radiation admiting and receiving devices that are provably dangerous to human health, I find myself ever more curious that we again knowingly act against our own best interest by ignoring the warnings and actual data.

It is a standard test, for instance, to use ultra-sound frequency in autopsy to literally activate and excite prions which in turn start mis-folding the healthy brain prions, infecting what is left of the healthy brain. This method is a specific frequency that benefits prions, and so the assumption is that there would also be an equal and opposite reaction with other specific ultra-sound ranges of frequency. Royal Rife certainly proved this to be the case with many organisms, speculating that all life had both health and death frequency ranges.

And so I musingly wonder if maybe, just maybe, it could very well be frequency that might be our Thing test.

Perhaps the foreshadowing of this in many science fiction movies may prevent us from realizing the reality of the fiction. After all, when Mars Attacks, no body really believes this can happen:

–=–

The alteration of the tuning of instruments is an interesting story, with the usual players. Rockafeller interests funded the United Nations in New York City, and thus within was spawned the International Standards Organization (ISO) based in London. From this organization was set the new global standard in musical tuning, from the harmonious and Biblical mathematical perfection of the healthy 432 hz to the now standard 440 hz, which is not harmonic with human health and vibration.

The very interesting history can be found here: https://atrueott.wordpress.com/2014/10/16/why-christians-and-worship-teams-should-tune-all-instruments-to-432-hz-and-abandon-440-hz/

So why the push to directly alter what was a standard tuning for generations?

Again, I can only state here that parasitic infection is a plausible answer to all of these questions.

After all this, one thing is certain. Mere conjecture as is posited here is not going to change anything. If indeed this theory is correct, we literally would have a war on our hands to save what remains of the natural order.

–=–
Archon Love
–=–

One final word about this theory… It’s not really mine.

While I am providing the evidence to support it, the truth is that this notion of mind parasites dates back for many centuries and from many different sources. The gnostics warned about these archons as demented mind parasites long ago. In my understanding, even the Bible warns not to cross species and races, perhaps even for this reason of creating unnatural chimeras. And yet here we are, cannibalizing our unborn like junkie freebasers, but for therapeutic reasons of course! Again I state that no one in their right mind would allow a doctor to inject human or animal proteins and DNA into their own body, especially aborted fetal tissue. But who among us is in their right minds? Logically, is it the vaccine user and abuser, or the “clean” vaccine opponent? The answer, it seems to me, lies microscopically within the very syringe in question.

The word archon is translated from Greek to mean ruler or lord, and sometimes master. The word is used to describe past kings, law-givers, and gods. But there is a more important translation I want to bring forward here…

Archaeon (är’kē-ŏn’) – Plural archaea – 

Any of a group of microorganisms that resemble bacteria but are different from
them in certain aspects of their chemical structure, such as the composition of their
cell walls. Archaea usually live in extreme, often very hot or salty environments,
such as hot mineral springs or deep-sea hydrothermal vents, but some are also
found in animal digestive 
systemsThe archaea are considered a separate
kingdom
 in some classifications, but a division of the prokaryotes (Monera) in
others. Some scientists believe that archaea were the earliest forms of
cellular 
life. Also called archaebacterium.

–The American Heritage® Science Dictionary

–=–

This is the story of the extremophile, including virtually indestructible prions. Extremophiles hate oxygen. They hate just about any environment that is healthy for human and animal life. Be it volcanos, hot springs, methane pockets, or deep freezes, the extremophile thrives in the antithesis of what we enjoy. It is important to note that with all of our meddling, the oxygen levels of the Earth are also shrinking away, again creating a more parasite friendly environment for these extremophiles while, not ironically, causing more disease susceptibility and infect-ability in humans. Just another modern global event that can certainly be explained by parasites. But nothing to see here, right?

Form the Encyclopedia Britanica we read the entry for archaea:

In some systems for classifying all of life, the archaea constitute one of three great domains of living creatures. In 1977 American microbiologist Carl Woese, on the basis of analyses of ribosomal RNA, proposed that the prokaryotes, long considered to be a single group of organisms (essentially, the bacteria), actually consist of two separate lineages. Woese called these two lineages the eubacteria and the archaebacteria. These names were subsequently changed to bacteria and archaea (the archaea being distinctly different from bacteria), but Woese’s splitting of the prokaryotes into two groups has remained, and all living organisms are now considered by many biologists to fall into one of three great domains: Archaea, Bacteria, and Eukarya. Further molecular analysis has shown that domain Archaea consists of two major subdivisions, the Crenarchaeota and the Euryarchaeota, and two minor ancient lineages, the Korarchaeota and the Nanoarchaeota.

Habitats of the archaea

Archaea are microorganisms that define the limits of life on Earth. They were originally discovered and described in extreme environments, such as hydrothermal vents and terrestrial hot springs. They were also found in a diverse range of highly saline, acidic, and anaerobic environments.

Although many of the cultured archaea are extremophiles, these organisms in their respective extreme habitats represent only a minority of the total diversity of the Archaea domain. The majority of archaea cannot be cultured within the laboratory setting, and their ubiquitous presence in global habitats has been realized through the use of culture-independent techniques. One commonly used culture-independent technique is the isolation and analysis of nucleic acids (i.e., DNA and RNA) directly from an environment, rather than the analysis of cultured samples isolated from the same environment. Culture-independent studies have shown that archaea are abundant and fulfill important ecological roles in cold and temperate ecosystems. Uncultivated organisms in the subdivision Crenarchaeota are postulated to be the most abundant ammonia-oxidizing organisms in soils and to account for a large proportion (roughly 20 percent) of the microorganisms present in the picoplankton in the world’s oceans. In the subdivision Euryarchaeota, uncultivated organisms in deep-sea marine sediments are responsible for the removal of methane, a potent greenhouse gas, via anaerobic oxidation of methane stored in these sediments. In contrast, uncultivated methanogenic (methane-producing) euryarchaea from terrestrial anaerobic environments, such as rice fields, are estimated to generate approximately 10–25 percent of global methane emissions.

The cultured representatives of the Crenarchaeota are from high-temperature environments, such as hot springs and submarine hydrothermal vents. Likewise, cultured members of the Euryarchaeota include organisms isolated from hot environments, organisms that are methanogenic, and organisms that grow vigorously in high-salt environments (halophiles). Organisms in the lineages Korarchaeota andNanoarchaeota also inhabit high-temperature environments; however, the nanoarchaea are highly unusual because they grow and divide on the surface of another archaea, Ignicoccus. Nanoarchaea, which were discovered in 2002, contain both the smallest known living cell (1/100th the size of Escherichia coli) and the smallest known genome (480 kilobases [1 kilobase = 1,000 base pairs of DNA]; for comparison, the human genome contains 3 million kilobases). Members of the Korarchaeota and Nanoarchaeota have not been detected in pure culture; rather, they have been detected only in mixed laboratory cultures.

Archaea are also found living in association with eukaryotes; for example, methanogenic archaea are present in the digestive systems of some animals, including humans. Some archaea also form symbiotic relationships with sponges; in fact, Cenarchaeum symbiosum was grown in the laboratory with its host sponge and was the first nonthermophilic Crenarchaeota to be cultured and described.

–=–

How many times have you heard the notion that a healthy human body must be in balance between acidic and alkaline Ph levels, and that disease flourishes in an acidic environment? Well so do archons (archaea). They like methane. They like extreme environments. They like stomach acid.

But more importantly they don’t like oxygen, they don’t like ozone, and thrive in anaerobic environments. Thus one curative measure might be to flood the body with the purest of oxygen, or to commit to oxygen therapy where the blood is oxygenated outside the body and reinserted. The trend and sophist popularity of anti-oxydents is suspect as well for these reasons. You can listen to my interviews with Mr. Oxygen (Ed McCabe) here:

Show #1 Ed McCabe (Mr. Oxygen):
https://corporationnationradioarchives.files.wordpress.com/2014/05/show140_may12.mp3

Show #2 Ed McCabe (Mr. Oxygen):
https://corporationnationradioarchives.files.wordpress.com/2014/05/show145_may19.mp3

His websites:

http://www.mroxygen.org/

http://oxygenhealth.com/

http://www.ozoneuniversity.com/index.html

Archaea are ancient forms of life compared to us. They are an RNA-based life form. It is RNA that controls the DNA switches of the epigenome. And the intelligence of this kingdom and domain of life is not measurable within the limited communication structure of man. We are indeed competitive life forms.

For a basic model of the communication and control that encoded RNA expresses over DNA, and how this archaea RNA life form might intercept that communication through transcription to control the host body, here is the technical jargon:

DNA transcription is a process that involves transcribing genetic information from DNA toRNA. The transcribed DNA message, or RNA transcript, is used to produce proteins. DNA is housed within the nucleus of our cells. It controls cellular activity by coding for the production of proteins. The information in DNA is not directly converted into proteins, but must first be copied into RNA. This ensures that the information contained within the DNA does not become tainted. DNA consists of four nucliotide bases [adenine (A), guanine (G), cytosine (C), and thymine (T) ] that are paired together (A-T and C-G) to give DNA its double helical shape. Nucleotide base sequences are the genetic code or instructions for protein synthesis.

Elongation – Certain proteins called transcription factors unwind the DNA strand and allow RNA polymerase to transcribe only a single strand of DNA into a single stranded RNA polymer called messenger RNA (mRNA). The strand that serves as the template is called the antisense strand. The strand that is not transcribed is called the sense strand. Like DNA, RNA is composed of nucleotide bases. RNA however, contains the nucleotides adenine, guanine, cytosine, and uracil (U). When RNA polymerase transcribes the DNA, guanine pairs with cytosine and adenine pairs with uracil.

Termination – RNA polymerase moves along the DNA until it reaches a terminator sequence. At that point, RNA polymerase releases the mRNA polymer and detaches from the DNA.

There are three main steps to the process of DNA transcription.

RNA Polymerase Binds to DNA – DNA is transcribed by an enzyme called RNA polymerase. Specific nucleotide sequences tell RNA polymerase where to begin and where to end. RNA polymerase attaches to the DNA at a specific area called the promoter region. Since proteins are constructed in the cytoplasm of the cell, mRNA must cross the nuclear membrane to reach the cytoplasm. Once in the cytoplasm, ribosomes and another RNA molecule called transfer RNA work together to translate mRNA into a protein. This process is called translation . Proteins can be manufactured in large quantities because a single DNA sequence can be transcribed by many RNA. Protein synthesis is accomplished through a process called translation. After DNA is transcribed into a messenger RNA (mRNA) molecule during transcription, the mRNA must be translated to produce a protein. In translation, mRNA along with transfer RNA (tRNA) and ribosomes work together to produce proteins.

Protein Synthesis: Transfer RNA – Transfer RNA plays a huge role in protein synthesis and translation. Its job is to translate the message within the nucleotide sequence of mRNA to a specific amino acid sequence. These sequences are joined together to form a protein. Transfer RNA is shaped like a clover leaf with three loops. It contains an amino acid attachment site on one end and a special section in the middle loop called the anticodon site. The anticodon recognizes a specific area on a mRNA called a codon.

Protein Synthesis: Messenger RNA Modifications – Translation occurs in the cytoplasm . After leaving the nucleus , mRNA must undergo several modifications before being translated. Sections of the mRNA that do not code for amino acids, called introns, are removed. A poly-A tail, consisting of several adenine bases, is added to one end of the mRNA, while a guanosine triphosphate cap is added to the other end. These modifications remove unneeded sections and protect the ends of the mRNA molecule. Once all modifications are complete, mRNA is ready for translation.

Protein Synthesis – Translation – Once mRNA has been modified and is ready for translation, it binds to a specific site on a ribosome . Ribosomes consist of two parts, a large subunit and a small subunit. They contain a binding site for mRNA and two binding sites for tRNA located in the large ribosomal subunit. During translation, a small ribosomal subunit attaches to a mRNA molecule. At the same time an initiator tRNA molecule recognizes and binds to a specific codon sequence on the same mRNA molecule. A large ribosomal subunit then joins the newly formed complex. The initiator tRNA resides in one binding site of the ribosome called the P site, leaving the second binding site, the A site, open. When a new tRNA molecule recognizes the next codon sequence on the mRNA, it attaches to the open A site. A peptide bond forms connecting the amino acid of the tRNA in the P site to the amino acid of the tRNA in the A binding site.

As the ribosome moves along the mRNA molecule, the tRNA in the P site is released and the tRNA in the A site is translocated to the P site. The A binding site becomes vacant again until another tRNA that recognizes the new mRNA codon takes the open position. This pattern continues as molecules of tRNA are released from the complex, new tRNA molecules attach, and the amino acid chain grows. The ribosome will translate the mRNA molecule until it reaches a termination codon on the mRNA. When this happens, the growing protein called a polypeptide chain is released from the tRNA molecule and the ribosome splits back into large and small subunits. The newly formed polypeptide chain undergoes several modifications before becoming a fully functioning protein. Proteins have a variety of functions . Some will be used in the membrane of the cell, while others will remain in the cytoplasm or be transported out of the cell. Many copies of a protein can be made from one mRNA molecule. This is because several ribosomes can translate the same mRNA molecule at the same time. These clusters of ribosomes that translate a single mRNA sequence are called polyribosomes or polysomes.

Source–> http://biology.about.com/od/cellularprocesses/ss/Dna-Transcription.htm

–=–

For the tech-savvy mind, we can read government sponsored research about signal transcription and communication between RNA archaea and human DNA here. It is very important to understand that this type of research is in mass and ongoing, and is very concerning when considering again our theory. Who or what is guiding these studies and for what purpose? And the real mind bending question becomes: Could man do this and other research and invention without a little help from his archaeon friends?

Determinants of transcription initiation by archaeal RNA polymerase.

Abstract

Transcription in Archaea is catalyzed by an RNA polymerase that is most similar to eukaryotic RNA polymerases both in subunit composition and in transcription initiation factor requirements. Recent studies on archaeal transcription in diverse members of this domain have contributed new details concerning the functions of promoters and transcription factors in guiding initiation by RNA polymerase, and phylogenetic arguments have allowed modeling of archaeal transcription initiation complexes by comparison with recently described models of eukaryotic and bacterial transcription initiation complexes. Important new advances in reconstitution of archaeal transcription complexes from fully recombinant components is permitting testing of hypotheses derived from and informed by these structural models, and will help bring the study of archaeal transcription to the levels of understanding currently enjoyed by bacterial and eukaryotic RNA polymerase II transcription.

Source–> http://www.ncbi.nlm.nih.gov/pubmed/16249119

 –=–

Transcription factor B contacts promoter DNA near the transcription start site of the archaeal transcription initiation complex.

Abstract

Transcription initiation in all three domains of life requires the assembly of large multiprotein complexes at DNA promoters before RNA polymerase (RNAP)-catalyzed transcript synthesis. Core RNAP subunits show homology among the three domains of life, and recent structural information supports this homology. General transcription factors are required for productive transcription initiation complex formation. The archaeal general transcription factors TATA-element-binding protein (TBP), which mediates promoter recognition, and transcription factor B (TFB), which mediates recruitment of RNAP, show extensive homology to eukaryal TBP and TFIIB. Crystallographic information is becoming available for fragments of transcription initiation complexes (e.g. RNAP, TBP-TFB-DNA, TBP-TFIIB-DNA), but understanding the molecular topography of complete initiation complexes still requires biochemical and biophysical characterization of protein-protein and protein-DNA interactions. In published work, systematic site-specific protein-DNA photocrosslinking has been used to define positions of RNAP subunits and general transcription factors in bacterial and eukaryal initiation complexes. In this work, we have used systematic site-specific protein-DNA photocrosslinking to define positions of RNAP subunits and general transcription factors in an archaeal initiation complex. Employing a set of 41 derivatized DNA fragments, each having a phenyl azide photoactivable crosslinking agent incorporated at a single, defined site within positions -40 to +1 of the gdh promoter of the hyperthermophilic marine archaea, Pyrococcus furiosus (Pf), we have determined the locations of PfRNAP subunits PfTBP and PfTFB relative to promoter DNA. The resulting topographical information supports the striking homology with the eukaryal initiation complex and permits one major new conclusion, which is that PfTFB interacts with promoter DNA not only in the TATA-element region but also in the transcription-bubble region, near the transcription start site. Comparison with crystallographic information implicates the PfTFB N-terminal domain in the interaction with the transcription-bubble region. The results are discussed in relation to the known effects of substitutions in the TFB and TFIIB N-terminal domains on transcription initiation and transcription start-site selection.

Source–> http://www.ncbi.nlm.nih.gov/pubmed/14597623

–=–

In biology, the word homology as used in this study refers to the existence of shared ancestry between a pair of structures, or genes, in different species. In other words, RNA archaea can interact with DNA humans. We are compatible in a parasite-to-host kind of way. If that still isn’t clear, the archons can control us like puppets by utilizing transcription factors in the DNA transcription (communication) process of transfer RNA in protien syntheses.

This is a little bit like explaining the way a computer works in its communication by viewing the movie TRON. In the human body, this communication process of transcription that creates who we are and what our intentions will be manifested as is a bit like writing a book. The RNA must enconde the DNA and thus send various proteins throughout the body, be it for the immune response or cognitive response. These proteins are small enough to penetrate the brain.

So what is the difference between these cells, and why should we be concerned that archaeon RNA is most similar to eukaryotic RNA in regards to this transcription process?

Cells in our world come in two basic types, prokaryotic and eukaryotic. “Karyose” comes from a Greek word which means “kernel,” as in a kernel of grain. In biology, we use this word root to refer to the nucleus of a cell. “Pro” means “before,” and “eu” means “true,” or “good.” So “Prokaryotic” means “before a nucleus,” and “eukaryoticmeanspossessing a true nucleus.” This is a big hint about one of the differences between these two cell types. Prokaryotic cells have no nuclei, while eukaryotic cells do have true nuclei.

Source–> http://www.cod.edu/PEOPLE/FACULTY/FANCHER/ProkEuk.htm

–=–

Could the archaea be attributed with other qualities as well, such as king-maker? Does it explain the bloodlines and blood-types of the kings and popes being exclusively Rh-, and are the archons passed from one infected generation to to the next? Can publications like the Talmud and the Authorized King James Bible be the manifestation of this control factor? What about non-linear, 4rth generation, and other modern warfare methods, as expressed in such documents as Silent Weapons for Quiet Wars and the Iron Mountain Report? Can it explain the notion of the usurious corruption in banking, government, and religion, where vast designs of enslavement and control of the mind are institutionalized in ways that seem so incredibly convoluted and hidden that they would be impossible for man to invent? Does it explain the subversion of all that is good and nurturing in nature?

In conclusion, it seems we are in a tough position. I can only appeal to logic and reason here by providing the verifiable facts that make up the outline of this theory, and yet those traits have seemingly been hammered out of the majority of us through the very entertaining science fiction and fantasy genres that apparently reveal this reality over and over through a similitude of variations in story-telling. It’s a perfect way to hide things in plain sight if you think about it. Even the phrase conspiracy theory may be used here, though its user should be poked with a stick and examined for sanity and for brain parasites when considering that the conspiracy referred to would be responsible for the cognitive dissonance of that fallacious name-caller. I sometimes wonder if that blank stare and disconnect from reality that appears in peoples eyes when speaking to them about reality and possibility and the lines in the sky that form clouds is not some chemically induced archaeon response mechanism to keep its host in the dark about itself, like the toxoplasmosis pleasure response for stupid behavior. But I can only speculate…

And perhaps in the end that is the most frightening aspect of this whole theory. For, like the pod-people from The Body Snatchers, these seemingly psychopathic scientists, doctors, biologists, and Geoengineers would never be allowed by their parasitic infection to allow a “clean,” parasite-free person to challenge this theory in search of proof for it with funding or legitimacy for research. We would be spotted immediately; if not only for our uncontrolled, inquisitive minds in asking simply why?

If anything, this would make a fine script for a science fiction story. If only we could guess the way to a happy ending…

.

–Clint Richardson (realitybloger.wordpress.com)
–Wednesday, February 4rth, 2015

I Am Not The People, And Neither Are You


It is the greatest of fallacies; indeed it might be the greatest public relations stunt ever conceived. It cannot be defined. It cannot be touched or spoken to. It cannot be seen. It has no substance.

And yet we as individuals identify ourselves as it with perfectly unhindered irrationality, while at the same time never being able to grasp its totality of non-existence. It is used to describe every last one of us, even when it singles out one of us to bully and plunder. It represents the basis of the entire structure of power over us, while at the same time somehow being us. And the power of it has created the most impressive false dialectic ever conceived in the history of the world.

Monarchies and dictatorships are surely envious of it, for even the most violent of militarized tyrannies cannot match the shear driving force of the consent of it. And all who oppose it have learned that no power in the world, including an act of God, seems to be able to stop it.

So just what is it?

It is the ambiguous title of “the People.”

In its most surreal application, the People is most often used to cause a lack of tangible responsibility for the actions of the People. Like the Dr. Jeckyl and Mr. Hyde model, the men and women that make up the citizenry of government can simply blame the government for everything done in the People’s name, even though it was supposedly done with the consent of the governed. For the government, the men and women that make up that legislature and Executive branch can simply blame the citizenry for giving their consent as the governed People, never admitting that their own actions (which are often despite the actual People’s will) were anything but the will of the People.

Either way, it seems, no one is ever to blame for the actions of the People because the People simply does not exist.

Does the People cast a shadow? Can the People be touched or seen? Can the People actually only speak with one voice, considering it supposedly equates to all the citizens in the nation? Can the elected officials somehow be the People despite the rest of the People just because those People voted for the legislators to be the voice of the People?

Just who, in the end, do you suppose is taking responsibility as the actual People? Is it the president? Is he the People when He decides to act as the People without actually consulting the People? Is the entire citizenry of People thus responsible as a collective People for the actions of the president acting as the People?

–=–
The People vs. The People
–=–

I can just imagine it… where all parties claiming to be the People actually go into arbitration so as to decide just who is in actuality responsible for the actions of government. It would be more devious than a divorce case, more televised than the O.J. Simpson case, and more flippant than a cat in a hot tub.

The common People would claim that the government committed a crime. The government would then counter-claim that the People voted for government, and therefore the crime was in the name of the People. But, so argues the attorney for the voting People, government is acting without consulting the People in its actions. To which government’s Attorney General retorts that the People gave consent for the government to act as the People in all things political, which really means that government is the spirit of the People. Nay, nay, says the common People’s representative, for the People have voiced in private and have called and sent petitions to these re-presentations of the People in government and spoken their individual opinions of government’s actions, and a majority of the People do not approve of government’s actions while acting as the People. And still in stalemate defiance, the government would claim that while the People certainly have the right to individually voice their personal opinions under the doctrine of “free speech”, says the Attorney General for the United States (i.e. the People), the People (government) is certainly not required in any way to consider the People’s (any citizen’s) individual opinions on the actions of government (the People)…

And at this point, Judge Judy slams her gavel down in Talmudic entropy and declares a mistrial due to irreconcilable differences in sameness.

And when the opinions of the case are written into case law, it would read that no distinction could be established in either separating the government from the People or the People from government, and that no individual citizen could claim to be the People, for all the People cannot be manifest in just one common person. Finally, it is the courts opinion that no individual or group of persons can claim to be the actual full body of People, because the People is a plural title for a singular body politic called the People. Therefore, only government can call itself the People, despite the fact that government is merely a fiction of law with no substance, and so the People cannot in fact sue the government for the government is in fact and in title actually the People.

Final decision: the case cannot exist because the People cannot sue the People. The government cannot sue itself. The People, therefore, must submit to the will of the People.

Here exists the hand of the People,
claiming to exist despite its non-existence,
presenting its own representation.

–=–
Say What?
–=–

If the above is confusing for you, ask yourself a few questions….

Are you a People? Is there any way that the word People can be a singular term that refers to only one man or woman?

Is government a People? Inasmuch as Walmart is a corporation, and the entire staff, board, CEO, shareholders, and owners could loosely be called a People, then yes.

Is government the People? How can government be all of us People if we are not voting for the actions or laws created by the small group of People in government?

Sure, we vote for which persons will inhabit government, but those People never ask permission from the rest of the People who voted for them when they pass laws on the People’s behalf. But if the government (the People) is able to put the responsibility of its actions on the entirety of all the People, then is it any wonder that the People never punish the People in government for crimes against the People?

Trying to figure out just what the People is at this point is like looking at an infinite, self-similar fractal. The beginning and the ending of just what the People is can never be truly be ascertained. And just when you think you have it figured out, you realize the paradox that its true quantitative power is that it is an equation with no solution – an impossible perfection of the political corruption of natural reason and logic.

 

Don’t get lost

–=–

How can such a nonsensical word as the People have been foisted upon the masses of men, who self-identify as both an individual sentient being and a fictional plural construct? How can hundreds of millions of men be convinced that they are not men but legally a single hive-minded political term known as the People? And from that experiential belief, how were so many strong-willed men able to be convinced that We, the People is the creator of all things and all laws, and that even though they are supposedly one of the People, the People can somehow single one of the individual People out and sue, fine, tax, punish, imprison, and even put to death that individual all in the name of that great god called We, the People? Amazingly, even as individual sentient beings, we still consider and address ourselves not as our selves, but as the whole People. I am We. We am I.

And therein lies the greatest word magic and trickery ever spell-cast. For by saying I am We, the People, a man is really saying I am of government. I am a fictional representation of myself. I am an individual fictional person and one of the fictional People at the same time? I am not man. I have no voice. I am totally controllable. I am a creation of government

Literally, my will is the People’s will, and so therefore the People’s will tells me my will, whether I like it or not, and whether the People them-selves like it or not. Cause there are no real People, just a bunch of subjects called persons. It’s all just a fiction. Just a name. A big lie.

–=–
Maxim’s Of Law:
–=–

“The creator controls.”

“A thing similar is not exactly the same.”

“One who wills a thing to be or to be done cannot complain of that thing as an injury.”

“He who consents cannot receive an injury.”

“Consent removes or obviates a mistake.”

“The agreement of the parties overcomes or prevails against the law.”

“Agreement takes the place of the law: the express understanding of parties supercedes such understanding as the law would imply.”

“No one can sue in the name of another.”

“It is immaterial whether a man gives his assent by words or by acts and deeds.”

“A fiction is a rule of law that assumes something which is or may be false as true.”

“Where truth is, fiction of law does not exist.”

“Whoever does anything by the command of a judge (magistrate/We, the People as god) is not reckoned to have done it with an evil intent, because it is necessary to obey.”

“Where a person does an act by command of one exercising judicial (magistrative) authority, the law will not suppose that he acted from any wrongful or improper motive, because it was his bounded duty to obey.”

 –=–

Why can’t anyone get in trouble by the law for crimes against humanity? Because People aren’t men! A man acting in person as one of the People has the permission of the People to do what the People tell the person to do on behalf of the People. In other words, if the People are sovereign, and a sovereign knows no law above it, then the People have no real law when acting as the sovereign We, the People, and pretend to operate their crimes under the law of the People! This is the simulacra and simulation of the People and of government. The People is a copy with no (living) original. The government is similar to the law but not the law; a simulation of God. This is the fractal reality of a great and powerful lie, the underlying law being truly that of anything goes.

Who, what, where, when, and how is the People?
Will the real People please stand up?

–=–

People is a fiction of law. The law, however, assumes that the fiction (People) is non-fiction (Mankind), and that therefore the fiction is true in the eyes of the law. The law says that all of mankind are a single People. Man acting as persons of the People (government) are acting in another name (in the name of the People), and so man acting in the name of or as the People can certainly not sue the government, for the government is the People, and the People cannot sue the People itself, and so this makes somehow a functional paradox we call justice.

The People cannot really complain to government, which claims to be doing the will of the People, because again the People cannot complain about the People. They are the same thing. One single body politic. On individual thing. E pluibus unum. One world order is merely a one world People of the same world government (the People). Individual nations are called “state’s” of the United Nations, and the member nations will just be the new People of the One World Nation. For ultimately, in a global government, the People that is the United States will only be considered one individual person in the United Nations.

Now don’t be confused, for it is easy to fall into the fractal trap of this word porn. A diehard “We, the People” person that just can’t imagine not being regarded as a plural and thus actually be responsible for his own actions despite the People he identifies himself as, and therefore as a real non-dependent man, is no longer able to blame government or his mistaken identity he calls the People for his or her own inaction; somehow blaming all other People as opposed to himself while simultaneously believing that he is indeed one of the People which he himself blames. Damn People!

Whoa there!

Seriously, before the fractal gets way out of hand (Mandelbrot would be so proud), let’s make sure that this whole diatribe isn’t just some modern abstract from a fractal crack-head’s dream…

Let’s see what this word People means in the legal books:

PEOPLE, noun [Latin populus.]1. The body of persons who compose a community, town, city or nation. We say, the people of a town; the people of London or Paris; the English people. In this sense, the word is not used in the plural, but it comprehends all classes of inhabitants, considered as a collective body, or any portion of the inhabitants of a city or country. 2. The vulgar; the mass of illiterate persons. The knowing artist may judge better than the people 3. The commonalty, as distinct from men of rank. Myself shall mount the rostrum in his favor, And strive to gain his pardon from the people 4. Persons of a particular class; a part of a nation or community; as country people 5. Persons in general; any persons indefinitely; like on in French, and man in Saxon. 6. A collection or community of animals. The ants are a people not strong, yet they prepare their meat in the summer. Proverbs 30:25. 7. When people signified a separate nation or tribe, it has the plural number. Thou must prophesy again before many peoples. Revelation 10:11. 8. In Scripture, fathers or kindred. Genesis 25:8. 9. The Gentiles. –To him shall the gathering of the people be. Genesis 49:10. – verb transitive  – To stock with inhabitants. Emigrants from Europe have peopled the United States. (–Webster’s 1828)

PEOPLEA state; as the people of the state of New York. A nation in its collective and political capacityThe aggregate or mass of the individuals who constitute the state… In a more restricted sense, and as generally used in constitutional law, the entire body of those citizens of a state or nation who are invested with political power for political purposes, that is, the qualified voters or electors… In neutrality laws, a government recognized by the United States. The word “people” may have various signification according to the connection in which it is used. When we speak of the rights of the people, or of the government of the people by law, or of the people as a non-political aggregate, we mean all the inhabitants of the state or nation, without distinction an to sex, age, or otherwise. But when reference is made to the people as the repository of sovereignty, or as the source of governmental power, or to popular government, we are in fact speaking of that select and limited class of citizens to whom the constitution accords the elective franchise and the right of participation in the offices of government. (–Black’s 4rth Edition)

PEOPLE – Ordinarily, the entire body of the inhabitants of a State. In a political sense, that portion of the inhabitants who are intrusted with political power; the qualified voters. The words “the people” must be determined by the connection. In some cases they refer to the qualified voters, in others to the state in its sovereign capacity. The United States government proceeds directly, from the people; is “ordained and established” in the name of the people. It is emphatically and truly a government of the people. In form and substance it emanates from them. Its powers are granted by them, and are to be exercised directly on them, and for their benefit.” Under our system, the “people,” who in England are called “subjects,” constitute the sovereign. The simple word “people”  is sometimes applied to a nation or foreign power. When the constitution of a State directs that processes shall run in the name of the State, a process in the name of the “people” will be held deficient, notwithstanding the form be statutory.” See Citizen; Country; Government; Lex, Salus, etc.; Magistrate; Nation; Sovereignty; State, Welfare. (–W.C. Anderson 1889)

–=–

Ever wonder why a petition never seems to work? That’s because a petition is not created by all the People, but only by some persons. Persons are not the People. In other words, a petition may be considered as legal evidence, but not as the will of the People. The People is a legal concept that the People can’t seem to access, though We are supposedly the People.

PETITION – A written address, embodying an application or prayer from the person or persons preferring it, to the power, body, or person to whom it is presented, for the exercise of his or their authority in the redress of some wrong, or the grant of some favor, privilege, or license.

PRAYERThe request contained in a bill in equity that the court will grant the process, aid, or relief which the complainant desires. Also, by extension, the term is applied to that part of the bill which contains this request.

PRAYER – chancery pleadings. That part of a bill which asks for relief. 2. The skill of the solicitor is to be exercised in framing this part of the bill. An accurate specification of the matters to be decreed in complicated cases, requires great discernment and experience; it is varied as the case is made out, concluding always with a prayer of general relief, at the discretion of the court.

–=–

We pray to the court, because the court is the god, an other word for magistrate, which is another word for government as the People. The court represents We, the People against us, either wholly or as individuals or corporations. We as individuals or groups, associations, or corporations are never addressing the court as the People, it is the Court that is addressing us as the People, because government is the People. It is impossible for the People to sue the court because the court is the People. The court offers the opinion of the People. All we can do is pray to that magi-god in a black robe for remedy. The word prayer has been modernly re-named into “pleading.” The People need not plead, for the court is the People.

–=–
The Chicken Or The Egg?
–=–

I’m not sure how many other ways I can say this, but it should be clear that I, you, we, and us is not the People. It’s a physical impossibility, which is part of the strategy of control. The government knows that the People can never be together in one room, acting as its true self – all the millions of actual voters. It’s a gloriously impossible feat. And that’s why the legal god that has been named the We, the People as a representation of the People is so powerful and seemingly immutable.

The only last fallacy to be consumed in the fire of this fractal debtor’s hell is to dispel the notion that the People created the government. Here again, the romantic patriotic view is that the People all voted for the constitution. Of course this is a verifiable untruth. Very few of the People could vote, because they weren’t good enough to vote due to blood, status, lack of land-holdings, and of course color. The People who created the constitution were clear on this 3/5ths of a point, which makes it humorous to see a patriotic “negro” man eager to wave the flag.

While it is accurate to say that the group of Free-masonic men who signed the constitution were certainly a specific, proper noun group of People, it is not accurate to say that they were all the People of the entire nation, any more than it is accurate to say that the legislature actually represents the will of every person in the United States as the People. It is more accurate to say that the individual states as body politics’ were the things that made up the People, and not the men within acting as citizens, slaves, and voluntary or involuntary servants. The People, as defined above, are the states of the nation and therefore is the nation itself. That’s not real People, that’s just an incorporated thing. An idol. A god.

How could there have been a People if there was no nation? Was there a specific day that all men became the People? They certainly weren’t natural born at the time they became the People. Could the People of a nation exist before the nation was created? Obviously, if none of us out here can represent the People in court, then we are not really the People.

If government disappeared tomorrow, there would be no place for the People to legally appear as a legal body. For the People only exist as and in a fictional jurisdiction. Government creates and becomes the People, and the creator controls.

And so I end this puzzling commentary with one last question…

When are you going to quit denying the beauty and wonder of your uniqueness and individuality, quit denying your personal responsibility, and quit letting evil men commit atrocious crimes against all the men and creatures of the Earth in your name – in the name of the god of We, the People?

.

–Clint Richardson (realitybloger.wordpress.com)
–Thursday, January 15th, 2015

The Absurdity Of Modern Free Speech


In light of yet another Talmudic spectacle of intentional despoilment of any respect America might have left in the world, isn’t it time to admit that from within the arsenal of complex patriotic weapons used as universal excuses for downright bad behavior, the free speech card has been well overplayed?

Watching the people of America being strung along like fiddles in quite forced romantic support for an at best mediocre movie before its release through a poorly-staged conspiracy worthy only of the lowest freak show display was painful. Despite the false dialectic of public outcry created by the now infamous ‘corporations are people too’ comment by Mitt Romney last election cycle – ridiculous not in its insanity but in its utterly soul-saturating truth – the collective dichotomy has now been sublimely shifted into supporting a corporation’s free speech in its release of a mainstream movie. For the doctrine of free speech is equally yoked in natural and artificial persons, thanks to the virtually unlimited exceptionalism given to the chartered 1st amendment.

No such demand would have been artificially created, plugged, and asserted through the magic of media trickery if the movie at question would have been a true historical documentary relating to a sympathetic view of Hitler and the easily proved false-history pertaining to the so-called “Holocaust.” In fact, even the very thought of public support for “free speech” as an excuse for the desire of making and releasing such a documentary film without protest or political barrier, provable as every fact would be, is a generally repugnant public opinion. For when push comes to shove, the responsibility that is implied in the creation of and thus use of this notion of free speech is being disappeared and then reappeared in the legal setting whenever it serves the interests of powerful men in their rewriting of current and past history.

Would a “comedy” put forth by the same two Jewish film-maker/actors and by the same Jewish-run media corporations with the plot of assassinating specifically the current President Obama through clandestine, covet means be acceptable free speech as well in this free speech society? By the current standards regarding “The Interview” movie it would. How about a snuff film about stabbing Mother Theresa to a bloody pulp with a crucifix, or better yet a splintery Dreidel? Does the amorphous, ambiguous term “free speech” also somehow protect such efforts in the purview of public opinion?

The question I pose today is a difficult one… Is free speech really to be considered an unrequited absolute?

Bearing in mind that the term “free speech” is not in any way defined in its constitutional proclamation in the articled 1st amendment, does the rational man truly believe that this is the legal version of anything goes? Can there be law without a foundation of some moral compass as a limit to the absoluteness of that law, especially when we consider that we are all forced to accept that even the most immoral speech is publicly acceptable because public opinion says all speech must be free and accepted?

And how soon will the element of freedom turn into the chains of subjection as the gavel of the supreme court resounds the new law that free speech and expression of opinion about certain Zionist factions only equals hate speech, as has happened in so many other “civilized” nations?

From both a logical and Biblical perspective, the answer is touted in support of the duties invoked by natural law (God’s law-order) to do no harm rather than to just accept this supposed unabashed liberty-without-responsibility assumed in the modern interpretations of constitutional theory. Here, Rousas John Rushdoony says it best in his foreshadowing warnings:

–=–

“…[A] society which makes freedom its primary goal will lose it, because it has made, not responsibility, but freedom from responsibility, its purpose. When freedom is the basic emphasis, it is not responsible speech which is fostered but irresponsible speech. If freedom of press is absolutized, libel will be defended finally as a privilege of freedom, and if free speech is absolutized, slander finally becomes a right. Religious liberty becomes a triumph of irreligion. Tyranny and anarchy take over. Freedom of speech, press, and religion all give way to controls, totalitarian controls. The goal must be God’s law-order, in which alone is true liberty.”

“Whenever freedom is made into the absolute, the result is not freedom but anarchism. Freedom must be under law, or it is not freedom…. Only a law-order which holds to the primacy of God’s law can bring forth true freedom, freedom for justice, truth, and godly life. Freedom as an absolute is simply an assertion of man’s “right” to be his own god; this means a radical denial of God’s law-order. “Freedom” thus is another name for the claim by man to divinity and autonomy. It means that man becomes his own absolute”

–Rousas John Rushdoony, The Institutes of Biblical Law
(The Presbyterian and Reformed Publishing Company, 1973) p. 581, 583–

–=–

As a rational man or woman, can the reader truly accept that this simple term “freedom of speech” was intended to equate to freedom from responsibility, ethics, respect, and from the very notion of the law itself? Can laws against such freedom of speech such as slander and perjury truly be subservient and bypassed by the right to free speech itself?

We have certainly defined the word freedom before on this blog, and so we know that political freedom is under the state of a false legal capacity. No matter which dictionary of law and court opinion we open, we find the same definition of the term.

FREEDOMLiberty; the right to do what is not forbidden by law. Freedom does not preclude the idea of subjection to law; indeed, it presupposes the existence of some legislative provision, the observance of which insures freedom to us, by securing the like observance from others. –Bouvier’s 1856

FREEDOM – The state of being free; liberty; self-determination; absence of restraint; the opposite of slavery. The power of acting, in the character of a moral personality, according to the dictates of the will, without other check, hindrance, or prohibition than such as may be imposed by just and necessary laws and the duties of social life. The prevalence, in the government and constitution of a country, of such a system of laws and institutions as secure civil liberty to the individual citizen. –Black’s Law 1st

–=–

The fact is that this notion of “free speech” in the constitution needs to be taken for its intent, not in its stretched out modern usage as an excuse for immorality and irresponsibility.

To be free in speech means to not be forced to say something against your will. This negative right, with regards to the legal setting, is designed to avoid false witness under coercion and to avoid self-incrimination, which means that the law cannot harm a man for speaking his mind or even the truth as a defendant or witness. Here though is assumed a sense of personal control and responsibility with our speech that it should not defame or arbitrarily defraud another, which the laws are clear to punish in perjury. And this free speech doctrine was not intended to apply to all aspects of personal life, only to political ones regarding rights and duties.

Does this specific notion of freedom from being forced to say something against ones will really imply too that a man (as a citizen) must thus allow any degrading, debilitating, slanderous opinion or untruth to be uttered at any time, tossing personal responsibility out the window while hiding under the false notion that all speech is protected by the god of the constitution; the god without substance known as We, The People?

This author believes the answer here to be no, at least with regards to the intent of the notion of what this doctrine of freedom of speech is with intent designed to protect. The concept of law is not designed to be used to force all speech upon others, any more than it is designed to force actions and political participation.

Frederick Nymeyer in Progressive Calvinism stated that:

“What gold is to money, the law of God is to liberty.”

When comparing this notion of personal responsibility with the modern perversion of the seemingly unlimited liberty of modern free speech, one must question just where the foundation of that doctrine may be found? Just as our U.S. dollar, as an unlimited currency, has no foundation in intrinsic physicality or morality (i.e. it is not “backed” by a foundation of gold) and is therefore without actual limit in its liberty of production, the currency of free speech in its projected unlimited capacity seems to be as well without foundation or principle in the modern era – totally misused, abused, and out of control! Both of these things seem to be killing us slowly; the bankrupting not only of our bank accounts but of our prosperity, integrity, and national reputation as well.

The public relations spectacle that was the Sony/Franco/Rogen/North Korea/Obama public opinion dilemma, as poorly played as it was, was quite effectual not only in positively publicizing the immorality and societal subversion of the Zionist Protocols of the Elder’s agenda, but also in the art of the swaying of public opinion without a day in court. It was a hoax of hoaxes; a successful subversion of reality and lawful intent. It was a typical American meme from the meme machine of Hollywood proper.

Should free speech be religiously used to protect all forms of speech?

Should this unlimited doctrine be protected even when the speech itself is offensive to law and freedom itself?

Should free speech be allowed to intrude upon the private rights of others?

And at what point does free speech become indistinguishable with forced speech, where you must hear it pumped into your living room and at work 1984 style and thus pretend to agree with it because the law forces you to accept and live by it as an unlimited right guarded by the thought police?

When is freedom actually redefined as objectified tyranny?

You decide…

And after your own contemplations, ask yourself why you allow others to define what is right and just in your own mind, what is correct and moral by the justice of legal code, and why it is that “entertainment” is now a legitimate title and excuse for pure unadulterated corruption and subversion protected by law?

The answer is simple and clear in all cases. Government is the supreme god (magistrate) from which all public opinion now flows.

MAG’ISTRATE, noun [Latin magistratus, from magister, master; magis, major, and ster, Teutonic steora, a director; steoran, to steer; the principal director.] A public civil officer, invested with the executive government of some branch of it. In this sense, a king is the highest or first magistrate as is the President of the United States. But the word is more particularly applied to subordinate officers, as governors, intendants, prefects, mayors, justices of the peace, and the like. The magistrate must have his reverence; the laws their authority. –Webster’s 1828

GODnoun – 2. A false god; a heathen deity; an idol. 3. A prince; a ruler; a magistrate or judge; an angel… 4. Any person or thing exalted too much in estimation, or deified and honored as the chief good.- verb transitiveTo deify. –Webster’s 1828

–=–

Is the law exalted too high? How about the magistrates as the law-givers and administrators? Do you as a subject of the body politic (e pluribus unum) even recognize that you worship the law of the gods as magistrates?

As the saying goes: Change your god, change your law… before God’s law becomes illegal.

P.S… This is what responsible speech looks like!!!

.

–Clint Richardson (realitybloger.wordpress.com)
–Thursday, January 8th, 2015

Free Your Mind: The Conference!


 

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–=–

“The natural liberty of man is to be free
from any superior power on Earth, and not to be
under the will or legislative authority of man,
but only to have the Law of Nature for his rule.”

–John Locke

–=–

Greetings to all… I have been invited to speak at the 2015 Free Your Mind Conference in Philadelphia, happening this April.

As one who has created and ran a similar conference before (and who never would have hoped to be an invited guest at one) I know how difficult it is to find support and promotion for such events, and even to pay the expenses. So I am asking all of my readers and listeners to my show at Republic Broadcasting to help spread the word.

The 3-day conference includes some of my personal hero-activists, from the poetic subversion of Larkin Rose to the bloodline genealogical chronicler Fritz Springmeier to “We Are Change” co-founder Luke Rudkowski. The conference is hosted this year by Bob Tuskin (bobtuskin.comthefreethoughtproject.com) and author, researcher and investigative journalist John Vibes, both billed to be conference speakers as well.

For a full list of speakers and ticket info go to the conference website here: http://freeyourmindconference.com/

The venue hotel is offering discounted rooms, and Bob tells me that the use of my given name “clint” as a promotion code will save you a bit of cash.

**Note: I will receive no payment or other compensation for this in any way folks. The charge for the conference is used to pay for guest’s expenses – to fly us all out there to speak and to give us a place to sleep. Otherwise, we fend for ourselves! I was in personal debt over $2,000 out of pocket when I tried to run one of these things back in 2010! So please support such endeavors.

 

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–=–
Special Extra Event
–=–

I will be leading a one-full-day organized post-conference tour of the Masonic origins of the United States in Philadelphia (the City of Brotherly Love) on Monday, April 13th. All are invited to join in without charge (bring bus/train fare), and any help in organizing this endeavor would be appreciated, including local sources and info as well as my fellow conference speakers and guests. Lunch, good times, wandering, learning, and whatever else presents itself.

I look forward to meeting face to face all the wonderful folks that have supported (or not) my efforts over the years. And I hope to finally have my first book completed and available at the conference, if I can get my ass in gear.

See you in Phili…

.

–Clint Richardson (realitybloger.wordpress.com)
–Friday, January 2nd, 2014

 

 

 

 

On Modern Mechanics Of Taxation


In days of old, the object of taxation was the physical plunder of intrinsic personal possessions such as money, foodstuffs, or other valuable considerations forcibly taken in support of the kingdom. The plunderers were known as tax-collectors; though by their plundered, public victims they were more commonly labeled by nicknames of reproach. The common opinion of the villages and townsfolk that paid this tribute to kings and dictators of tyrannical despotism was disdain and controlled rage – a will for freedom lacking way and means.

In our modern taxation stratagem, the rules of the game have changed dramatically. In fact, the very comprehension of tax-plunder has morphed into a custom whereby most people have no idea they are being taxed. Indeed, it is ridiculously parroted by the children of parents of great grand parents that death and taxes are the only certainties in life. For the children of indentured debtor parents have no rational idea what liberty from despotism might look or feel like. Taxation has not only become customized and normalized into the social meme, but the plunderers have actually trained the children of despotism to root for the taxman over their fellow citizens.

To even attempt to imagine the people of old cheering the kings’ tax-collectors as they razed each hut in the village to satisfy the kings’ court is a preposterous notion. For it was well-known that these collections agents of the crown were backed by the full military force and sword of the king!

Though nothing has changed (except perhaps that the kings crest and sword is now a badge and gun), we now have reality television shows appealing to the mass delusion as they depict debt-collectors, repossession agents, pawn shops, and bail-bondsmen as the modern day champions of the people. In this absurdity of an attempt to manufacture public opinion in favor of legal plunder for the kingdom, cognitive dissonance has been shrouded over the intellect of the plundered majority class of “tax-payers” so as to create a Colosseum of bread and circus entertainment as the reinforcement of very bad behavior. In short, plunder has been woven seamlessly into the political process while the mass of victims have been generation-ally bamboozled (educated) into cheering on the plunderers while their fellow debt-slaves are put in pain and suffering at the hand of tyrants – a virtual public display representative of those antithetical Christian’s of antiquity being fed to the lions.

Today, taxation has been streamlined in such a way that most citizens have no idea they are being taxed, for the government doesn’t ever have to go into the realm to actually and physically “collect” taxes. This modern method of unlimited plunder through the false dialectic of and name of taxation could only be accomplished through the creation of a fiat currency; one with unlimited creation potential, where the collateral does not define the value of the note. In the case of United States Federal Reserve “dollars,” most of which are created in ledger or digital form with no actual substance, we see the potential for not only unlimited creation, but in turn for unlimited taxation. Even the wasting, spending, or cancellation of creation does not equate to a cancellation of the taxation assumed by the creation.

So how does this compare to the historical collection of real assets by force as tax and tribute to the king and his dominion (king-dom)?

Oh, it’s much more profitable for the dictators (lawgivers of government) today.

We have no tax-collectors today. Taxation (tribute) then was an obligation of servitude and subjection to the kings’ realm and privileges. It was obviously fraud, and those who suffered it made no mistake to ever think differently.

Today, we only have debt-collectors. They do not collect tax, they extort false debt. For the tax is collected without anybody even realizing it, and no collector is needed. Let me explain…

When the lawgivers of the kingdom (congress) wish to generate wealth through what used to be called tax-collection, they simply write some official legal words down on a paper and place a stamp of approval upon it featuring the seal of the nation (king-dom). While kings and despots had to send agents into the communities to collect real assets, this congressional act or “bill” is an instrument of exchange, where congress literally appropriates money into existence. They then place that “bill” into the legal records of the United States, a bank account known by name as the state of “national debt”, where the citizenry (loyal subjects) of the king-dom’s dictators agree through manufactured consent to be responsible obligators of that debt. Another word for this is constitutor, which means debtor, as a constitution is merely a compact of debt and obligation in exchange for privileges and immunities and is always designed to be against (immune from) the laws of nature and the personal responsibilities of individuals.

Within this ingenious device, the lawgivers are able to create unlimited taxation to financially support their plans in artifice. With unlimited taxation power comes unlimited authoritative power. How else could they fund the military industrial complex every year that protects their king-dom from us without appropriating new debt upon the taxpaying public with each new appropriations bill?

Check please!

The taxation methods we have become accustomed to today as schemes ranging from income to sales tax and any one of hundreds of clever extraction, extortion, and exaction methods, not the least of which is false inflation derived from false market fixing and illusions of supply and demand shortages, are merely devises of debt collection. Whereas before the sword was obvious and in your face for refusal to pay, appropriations cannot not be paid. They are automatic. The tax is collected the minute it is created as a credit to government’s coffers. And the credit represents a debt that must be paid by the people of the nation.

Unlimited credit, in other words, is the most important tool of a money system that has no limit. For the creditors are never the debtors, and these lawgivers as plunderers don’t mind being part of the plundered society, for they simply exempt themselves from debt collection by their own military force or they pay their taxes with the plundered money to give the illusion that they too are good little citizens as debtors.

As I explained in an earlier post, located here: your current taxes are already spent! They are spent the moment they are created out of thin air! For any taxes you pay today are only paying for the national debt of former appropriations by congress. The lawgivers don’t spend tax money, they create it as debt. They spend their bill before it is even monetized by appropriating the new debts to specific government functions in their appropriations bill. And the new total is simply added on to the ever-expanding check that is perpetually handed to the collective of tax-payers.

The moral of this story?

By consent, we have given total authoritative power via the power of the purse to the most corrupt of men, for the cream of corruption always rises to the top. The salt of the earth always sink to the bottom of the mix, paying for the debts of the cream by way of innocence to the designs used against them. The salt continues to flavor the combination from their own labor and through taxation on that labor, while the cream never mixes with the lower class. They stay at the top where they belong, the cream of the crop of the criminally insane.

When the bill collectors come a knocking your door down or blowing your house away, remember that it was congress that created this concoction of acrid evil in the first place, and that it only continues to have authority because you consent to it as a voluntary citizen and taxpayer.

At least the men of old knew they were being burned and eventually would fight to keep what was theirs as products of their own labor. They could and did fight back physically, or even tar and feather the king’s agent in boycott.

Modern man is absolutely blind to his own, self-aggrandized, patriotic responsibility to his master, and has nothing to keep because the money and possessions he holds are already the property of his master. The money is fake, and so is the king-dom. The city is a debtor. The county is a debtor. The district is a debtor. The State is a debtor. So what is left to fight? You cannot tar and feather a digital transaction. And police are security guards ensuring protection of these corporations from the tax-payers.

It’s a perfect system of chattel slavery, a fiefdom of clueless subjects that in the end worship and pay tribute to nothing but fiction, from the money to the offices that create it.

We are a defeated people who quicken in our perishing due to a strict lack of contemplation and knowledge of our own enslavement.

That is just another way of saying we deserve exactly what we beget.

But never mind… go about purchasing Christmas gifts with government’s debt instruments, even though each and every dollar represents the embodiment of your own debt-slavery to its creators in the Treasury. Pretend that a billion kids aren’t starving around the world. Be the empire of greed and artificiality we were manufactured and determined to be. For it’s not that christ is missing from Christmas, it’s that the teachings of the christ is missing from self-proclaimed christians, who would never celebrate the twelve pagan-zodiac days of corporate Christmas and the imagery and majesty of Saint Nick if they weren’t worshiping mammon.

We must be governed by our own consenting hand, for we are apparently not capable of resistance to unfettered tyranny and greed or to the false reality of this matrix.

Checkmate.

.

–Clint Richardson (Realitybloger.wordpress.com)
–Monday, December 22nd, 2014

Crash: Why America Will Fall Under Its Own Shadow


As a deep researcher into what is jokingly called the economy, I am getting real tired of “economists” and their dyer warnings of eminent monetary failure and thus the collapse of the so-called U.S. “economy.” I am not an economist. In truth, anyone who claims to be one is quite frankly full of shit.

So why did I title this rant as such?

First of all, let’s dispel the fallacy that the United States needs currency to rule. The United States is a military dictatorship, a fact that I will be proving beyond any doubt in my upcoming documentary film in 2015, God willing. It is ridiculous to then consider that the United States is propped up merely by money, especially when it creates that money magically through appropriation without providing new collateral. In reality, the fiat currency is nothing more or less than debt. It is promises to pay that will never be paid, for no debt can ever be paid with debt. The United States is a bankrupt corporation, as James Trafficant stated in congressional record, and a bankrupt cannot create anything but more debt.

As stupid humans, we are trained and conditioned to believe that the dollar represents something tangible with a somehow intrinsic value. I assure you it does not. But if my word isn’t good enough for you in all of your religious fervent belief and faith for said notes of mammon, let’s hear straight from the horses mouth.

The Federal Reserve, in its publication Modern Money Mechanics, states the following:

While currency is used for a great variety of small transactions, most of the dollar amount of money payments in our economy are made by check or by electronic transfer between deposit accounts. Moreover, currency is a relatively small part of the money stock.

In the United States neither paper currency nor deposits have value as commodities. Intrinsically, a dollar bill is just a piece of paper, deposits merely book entries. Coins do have some intrinsic value as metal, but generally far less than their face value.

What, then, makes these instruments – checks, paper money, and coins – acceptable at face value in payment of all debts and for other monetary uses? Mainly, it is the confidence people have that they will be able to exchange such money for other financial assets and for real goods and services whenever they choose to do so.

Who Creates Money?

Changes in the quantity of money may originate with actions of the Federal Reserve System (the central bank), depository institutions (principally commercial banks), or the public. The major control, however, rests with the central bank.

The actual process of money creation takes place primarily in banks.’ As noted earlier, checkable liabilities of banks are money. These liabilities are customers’ accounts. They increase when customers deposit currency and checks and when the proceeds of loans made by the banks are credited to borrowers’ accounts.

In the absence of legal reserve requirements, banks can build up deposits by increasing loans and investments so long as they keep enough currency on hand to redeem whatever amounts the holders of deposits want to convert into currency. This unique attribute of the banking business was discovered many centuries ago.

It started with goldsmiths. As early bankers, they initially provided safekeeping services, making a profit from vault storage fees for gold and coins deposited with them. People would redeem their “deposit receipts” whenever they needed gold or coins to purchase something, and physically take the gold or coins to the seller who, in turn, would deposit them for safekeeping, often with the same banker. Everyone soon found that it was a lot easier simply to use the deposit receipts directly as a means of payment. These receipts, which became known as notes, were acceptable as money since whoever held them could go to the banker and exchange them for metallic money.

Then, bankers discovered that they could make loans merely by giving their promises to pay, or bank notes, to borrowers. In this way, banks began to create money. More notes could be issued than the gold and coin on hand because only a portion of the notes outstanding would be presented for payment at any one time. Enough metallic money had to be kept on hand, of course, to redeem whatever volume of notes was presented for payment.

Transaction deposits are the modem counterpart of bank notes. It was a small step from printing notes to making book entries crediting deposits of borrowers, which the borrowers in turn could “spend” by writing checks, thereby “printing” their own money.”

–=–

Can you see past the illusion?

Do you see that the so-called debt doesn’t actually represent anything at all in reality?

Do you understand that debt is the basis of all religion, and that your belief and fear in it is all that substantiates it?

When this system of monetized fakery was created, its goal was not to create wealth. For money is not wealth, it is the opposite of wealth. It is debt. It must be traded in exchange for wealth to fools. If an entire nation and planet of people can be made to believe that this debt is actually a credit, then the debt can be traded for actual wealth. In other words, an entire people can somehow be made to believe that everything in reality can be traded for merely a promise to pay, and that this promise to pay is the same as the payment itself.

As Whimpy perpetually says, we will be paid Tuesday for a hamburger today… but Tuesday never comes.

As I have shown in triplicate, government has done just that. It has created the currency, traded it for corporate stocks, foreign currencies, real estate, precious metals, and anything else representative of real wealth to the point that, as Walter Burien claims via the Comprehensive Annual Financial Reporting (CAFR) system of government accounting: “Government owns it all through investment.”

–=–
Why America Is No Longer Needed
–=–

Rome is not stationary. It’s empire extends to every corner of the globe, and its center continuously relocates itself. Its name changes as its fraud is re-discovered, re-establishing itself as the need arises. And this is when the crash comes – the revolutions of past empires.

But revolution means to revolve back to the beginning; to start over again. Same empire, different name. This is why so many movies and other media is predictively programming us to support such revolutionary dissonance. Our ideas are very seldom our own, and obviously neither are our ideals of morals and values. Entertainment enters and holds our minds in whatever political thought processes the military ruler wishes to bore into its subjects. As a former Hollywood sound guy, I have seen the script-changes ensuring favorable praise and pro-government propaganda first hand, to the chagrin of writers that are paid more “money” to cooperate or else get their projects shelved.

In other words, we literally sell our souls for debt. We worship it. We trade assets for promises to pay. And we even hoard the debt notes in the illusion of security, as if debt equals safety. Unfortunately, our unreasonable belief and faith in this debt money (the devil’s currency) has lead us to covet the very thing that is killing us slowly. We therefore defend these promises to pay even to the point of war and violent oppression of the entire planet, giving blind and unwavering support to our dictators in congress and in the militarized Executive branch to kill in our (the people’s) name for the protection of our own disease of debt in its world domination.

But things are about to change…

The world is completely taken over. Almost every sense of resistance to the United Nations and what is deemed the “New World Order” by every president in recent memory has been squelched and replaced with “friendly” regimes. It is now common practice for the United States to arm both sides of every conflict while training “peace-keepers” to take over when the U.S. military withdraws from its illegal occupation in undeclared war, usually via Executive Order or other Executive (forceful) violence.

The fall of Iran seems to be the last great international challenge. Iran stands as the last hold out. And it is more demonized with every passing day.

Russia, China, and other imaginary enemies fill up the interim, but don’t be fooled. Government investments in China are why China is any power at all. And Russia wasn’t just allowed to build up its infrastructure because the United States was asleep. U.S. bases are in every state and in every nation around the world. These are not peaceful settlements, they are military occupations. No money is needed. It is rule by force, not by economics!

But with all of this military might, how is it that the U.S. will “crash?”

In the art of war, the assassin must be killed once its job is done. The United States has all but served its purpose. It has assassinated all resistance. It’s culture (which is a lack of established culture and moral law) has been infused with most other nations. Its fake currency has bought up the world “economy,” and that wealth can easily be transferred out to the world bank, leaving the people of America hopelessly destitute. With trained peace-keepers keeping the violent peace under United Nations’ purview, the centralization of military power can now be unilaterally acquired by the U.N. The United States as a mere member state of the United Nations can and is being equalized with all others.

The necessary symbolic crash of the United States central bank and currency is absolutely a requirement for global governance, where all nations are equal as the states of this United States are pretended to be. The centralized power as military force of the United States must be dismantled for the Roman phoenix to rise in its new form of global governance. And the only way to accomplish such a seemingly impossible feat is to play the only card left in the deck – the illusion of economic collapse through the “crash” of the fake currency.

Only if the people believe in that currency as real and intrinsic can this be accomplished, just as the Federal Reserve reports above.

Why is the mainstream news now sound-biting the horrors of the Fed and propagandizing the notion of “End The Fed” as a rallying cry? Does that really make sense considering that government is the majority stock-holder of all media agencies and stocks them with Operation Mockingbird parrots of the CIA, even while it saber-raddles for the destruction of Iran? Why is the totally controlled news constantly injecting fear-porn into the general public about the eminent financial crash of America? Why is it selling gold and storable food while continuously warning about earthquakes, economic upheaval, world war, and emergency preparedness?

The answers should be obvious.

The United States has done its job; its drugged, dumbed-down population used as cannon fodder as paid mercenaries for the military corporation. The borders are open. It’s business globalized. It’s independence subverted.

The shadow of America is the corporation 10 miles square called the United States corporation. And the 50 individual states that we romantically call “America” have fallen prey to their own so-called central government, where the ten planks of the Communist Manifesto are indeed the verifiable written law. The shadow of forced unionization has destroyed an unwitting people that have no idea they are proclaimed as enemies of their own central foreign state, that their shadow military occupies each of the 50 states under Leiber Code statutes, and most importantly that their currency is and always has been nothing but debt obligation and enslavement – the land of the free subjects; a cruel joke played out through an un-winnable game of monopoly at gunpoint.

The reality is that the national debt (a negative) can be abolished and jubilee’d tomorrow with the swipe of a presidential or congressional pen. It doesn’t exist in nature. It is born and will die on legal paper. But its power of illusion is so strong that the fiction of government and its fake money will cause reality to crumble right along with it. The gambling house called the stock market may crash into obscurity, but the ownership in international corporations will remain as the real wealth is transferred away. For a stock’s value is meaningless because what it is valued in is worthless debt in the form of promises to pay. It is the ownership that is important, representing controlling stake in all corporations despite what debt currency it is monetized and valued in. For all currencies are merely debt.

There are no banks left, for there is no lawful (real) money left to be banked. Deposit institutions are not banks, they are debt brokers. If you don’t understand this, then go try and deposit a gold bar or coin into “Wells Fargo Bank” or “Bank of America” – banks in name only. You cannot. No reality allowed. You can only rent a box to safely deposit your tangible property and hope it isn’t confiscated like in the last so-called “banking emergency.” Checking accounts only house promises to pay and nothing else.

The shadow government is killing its creator.

And belief in its own declared, de facto, prima facie evidence of legitimacy is all it will take to deliver the final blow.

It will be our own sons and daughters as career mercenaries that will be our own peace-keepers at home. Their uni-forms already bear the United Nations regalia and patch-mark.

.

–Clint Richardson (realitybloger.wordpress.com)
–Sunday, December 21th, 2014

The Prion Chronicles: The Story Of Interferon


 

These are the continuing chronicles of prion disease, the reason for your own state of unease.

For past research and understanding of just what a prion is, see my previous research here:

Link–> https://realitybloger.wordpress.com/2012/11/11/xenotransplantation-creating-the-zombie-appocalypse/

Link–> https://realitybloger.wordpress.com/2013/02/20/the-prion-chronicles-prions-and-als/

–=–

I wish to pose a question…

Is it possible that, in our efforts to create synthetic drugs (for profit) in order to artificially mimic or replace the body’s natural health and healing processes, even while suppressing the body’s immune response to those drugs so that they may fool the natural system, we have inadvertently created a permanent state of dis-ease as the average human condition?

Let’s take an obscene example.

Over half a century ago, while researching the efficiency of the vaccine for smallpox, Japanese virologists working for the Institute For Infectious Diseases at University of Tokyo published their findings (1954) that some “viral inhibitory factor” was inhibiting the growth of their purposefully induced viral infection of laboratory research rabbits. In other words, the tiny rabbit bodies were having the natural immune response they should, which interferes with the capability of a foreign zoological pathogen to propagate (grow and reproduce) after injection. But they also discovered through isolation of this unknown and naturally occurring preventative substance that it was not originated from antibodies. The desired immunization process of antibody stimulation through vaccination was being profoundly prevented.

Three years later, at the National Institute for medical Research in London, virologists discovered similar causal effects on the growth if influenza virus in chicken egg membranes. Something was again naturally interfering with the growth of the virus after purposeful (unnatural) injection. In their research paper they coined this viral inhibitory factor as “Interferon“.

At the same time, back at the University of Tokyo, those same Japanese virologists finally discovered the essense of what they originally coined as “Viral Inhibitory Factor (VIF)”,  and both research branches agreed that this anti-viral substance was caused by the same class of factors, and eventually these became officially known in medical science as “Interferon” (multiple types).

Further study revealed that these Interferon proteins reside in different human chromosomes, and a purification process of biologically active beta interferon was finally isolated in 1977. By the early 1980’s interferon protein types were isolated and cloned to show conclusive proof that indeed interferons were responsible for interfering with viral reproduction. Eventually, these interferon isolates were used as a treatment for viral infections.

So what are these naturally interfering produced factors, and why do pharmaceutical corporations hate them so much that they seek to interfere with their pre-programmed interference?

Clinically defined, Interferons (IFNs) are proteins (glycoproteins called cytokines) made and released by healthy host cells (naturally occurring cells in your body) in response to the presence of pathogens such as viruses, bacteria, parasites, or tumor cells. They literally act as communication devices traveling as RNA messengers, allowing cells to communicate with each other like micro text messages, creating a trigger effect to “interfere” with disease and viral replication by turning on the protective defensive structure of the immune system that is responsible for activating immune cells (natural killer cells, macrophages, etc.). Interferons also increase the ability of uninfected host cells in their ability to resist new infection by virus (an invading parasite to the host cell), and communicate the known presence of tumor cells to the immune system, up-regulating antigens to T lymphocytes.

A lymphocyte is one of 3 cells from the vertebrate’s immune system found in the lymphatic system called NK (natural killer) cells, B  cells, or T cells. There are currently identified 10 distinct interferons (IFN’s), 7 of which are found in humans. These are further broken down by classes (types 1, 2, and 3). All of these IFN’s are vital for the body’s defense against disease states and infections as well as prevention of tumor growth.

In layman’s terms, we could say that all of the body’s naturally healthy cells send out cell-phone calls in the form of amino acids (proteins), which float through the body as if upon a wirelessly fluid Ethernet, directly connecting to the body’s receiving phone-line like a 911 emergency call; thus literally summoning the body’s first responders in the form of the immune system to send out little firefighter cells (Natural Killer, B, and T-cell lymphocytes) to stop the spread of the fire caused by viral, bacterial, parasitic, or tumor causing pathogens that are invading the host cells.

–=–
Those Pesky Little Interferons
–=–

While interferons have been used in some cases as a breakthrough yet totally underutilized treatment for the slowing or halting of certain disease growth in humans, we find a much more sinister reason for such research and identification of interferons in modern medicine and vaccine production. You see, the original discovery of interferons was not an altruistic attempt to isolate and synthesize an amino acid compound that would treat disease. In fact, far from it…

Back in 1956, those Japanese and British virologists were not trying to cure disease. No, they were trying to induce disease within their animal subjects for research purposes and spread it into chicken eggs so as to grow the disease for vaccination and “other” purposes; chicken embryo substrates being the most popular method for disease culture growth. But as they learned through continuous interference from the host subjects, something kept getting in the way of their purposeful disease infection of those hosts – an at the time unknown intracellular function of the body as of yet unknown, later to be named as Interferon.

Please understand… in order to vaccinate against disease, these scientists believed that they had to stop the bodies own natural defense against the very disease these scientists were trying to purposefully infect their test subjects with. Some might call this a paradox… or just insanity. In order for their pseudo-science to supposedly work, those virologists had to figure out a way to cut the cell-phone signaling process (now known as interferon) caused by their purposeful inoculate infection of the hosts. They needed to cause the body to cease in its perfectly natural capacity to fight the very disease they were injecting into it, so as to grow the disease within that host body. This would seem to the average person to be, on the surface and rightly so, a counter-productive effort on their part. But then the average person could never comprehend what was happening behind the scenes, let alone the true purpose of funding such experimental “science” as medicine.

Let’s take the phenomenon known as Auto-Immune Deficiency Syndrome (AIDS) for example…

What are its symptoms?

Rare cancerous tumors, viral-like infection, wasting syndrome, and general immune-supression of the lymphatic system.

Sound familiar? Like maybe the body’s phone-lines are down?

The body works though a system of communication devices in bilogical form. When one part or system of the body needs to communicate with another, it does so through a highly advanced structure of expressive signaling and transduction; the release of various types of cells, proteins, and other substances that trigger each inter-dependent system to respond in kind. It is this body-wide platform of cellular communication that is being attacked and blocked by the introduction of inhibiting factors like infectious prions and other melevolent substances.

The body works just fine until it is stung and thus injected (vaccinated) with foreign proteins, DNA, RNA, and other ingreedients that in no other way would ever be able to insert themselves into the body of man (or rabbit).

The main issue with AIDS patients is the lack of the body’s immune response regarding the production of T Lymphocytes, commonly called T-cells. For some reason, despite the body’s many dis-ease states as symptoms of the AID-syndrome,  the body just isn’t getting the hint to produce the very thing that it needs to fight infection. It seems we have a failure to communicate here… For some reason the emergency 911 cell-phone lines seem to be cut, and the first responders (T-cells) are just not being called into action by the healthy cells that are under attack. Their chemical screams for help are going unheard. It’s as if the immune system labor union went on strike, and these “AIDS” symptoms are the resulting chaos and unrest that ensues throughout the body.

Not ironically, these are the same symptoms of what is known as Gulf War Syndrome, a known vaccine induced disease state thought by many researchers to be caused by vaccine adjuvants like squalene and other ingredients injected into the guinea pig soldiers of our military.

But what could possibly cause such a chain reaction throughout the body’s immune-supressive system?

What could possibly have been introduced within the body to prevent its ability to make a protein phone call, just like in those poor test-rabbits so many decades ago?

What is preventing interferon from interfering with the disease process, defeating its attempts to transmit its signal for help to the imune system?

Enter bioengineering and the novel prion…

https://i2.wp.com/i10.photobucket.com/albums/a123/Adrale/mailedD0.jpg

https://i2.wp.com/www.rense.com/general54/LexmarkAIOScan34.jpg

So how could this novel disease state be simultaniusly spread
throughout Africa and eventually the first world?

.

–=–
Altering Gene Expression: Just A Little Pinprick
–=–

.

“The genetic code is universal….
The complete word-for-word universality of the genetic dictionary is,
for the taxonomist, too much of a good thing.”

–Evolutionist Richard Dawkins, in his book,
‘The Blind Watchmaker’ (1986, p. 270)

–=–

“It is recognized by molecular biologists that the genetic code is universal,
irrespective of how different living things are in their external appearances.”

–Creationist Robert Kautz, in his book,
‘The Origin of Living Things’ (1988, p. 44)

–=–

“The construction and metabolism of a cell are thus dependent
upon its internal ‘handwriting’ in the genetic code.
Everything, even life itself, is regulated from a biological viewpoint
by the information contained in this genetic code.
All syntheses are directed by this information.”

–A.E. Wilder-Smith, United Nations scientist (1976, p. 254).

–=–

“It may seem a platitude to say that the offspring of buttercups, sparrows and human beings are buttercups, sparrows and human beings… What then keeps them, and indeed living things in general, “on the right lines?” Why are there not pairs of sparrows, for instance, that beget robins, or some other species of bird: why indeed birds at all? Something must be handed on from parent to offspring which ensures conformity, not complete but in a high degree, and prevents such extreme departures. What is it, how does it work, what rules does it obey and why does it apparently allow only limited variation? Genetics is the science that endeavours to answer these questions, and much else besides. It is the study of organic inheritance and variation, if we must use more formal language.”

–British geneticist, E.B. Ford,
‘Understanding Genetics’ (1979, p. 13).

–=–

“Tablets of stone prepared by the Babylonians some 6,000 years ago have been interpreted as showing pedigrees of several successive generations of horses, thus suggesting a conscious effort toward improvement. Other stone carvings of the same period illustrate artificial cross-pollination of the date palm as practiced by the early Babylonians. The early Chinese, many years before the Christian era, improved varieties of rice. Maize was cultivated and improved in the western hemisphere by the American Indians, beginning at an early period in their history. In another era, Hippocrates, Aristotle, and other Greek philosophers made observations and speculations suggesting genetic principles.”

–Eldon Gardner, ‘The History of Biology’ (1972, pp. 399-400)

–=–

“And God said, let the earth put forth grass, the herb
yielding seed,  and the fruit tree yielding fruit after its kind,
wherein is the seed thereof upon the earth, and it was so.
And the earth brought forth grass, the herb yielding seed and
the fruit tree yielding fruit after its kind whose seed was in itself.”

–The Bible, Genesis 1:11-12

–=–

“In the first chapter of Genesis, however, because it is a matter of the greatest religious importance, the Bible speaks clearly and finally on a matter of biology. After its kind is the statement of a biological principle that no human observation has ever known to fail. The most ancient human records engraved on stone or painted on the walls of caves bear witness to the fact that horses have ever been horses, bears have ever been bears, geese have ever been geese, reindeer have ever been reindeer. The most desperate and subtle efforts of man in modern times have been unable to alter this divine decree. The Bible teaches that from the beginning there have been a large number of types of living things, man included, which were so created as to remain true to their particular type throughout all generations…. The latest results of modern biological research, Mendel’s Laws, agree exactly with what was written by Moses three thousand years ago—and they also elucidate it…”

Byron Nelson, ‘After Its Kind’, (1967, pp. 3,103)

–=–

“…once a fertilized, (a) single human cell begins to develop, the original plans are
faithfully copied each time the cell divides (a process called mitosis)
so that every one of the thousand million million cells in my body, and in yours,
contains a perfect replica of the original plans for the whole body”.

–Evolutionist John Gribbin (1981, p. 193)

–=–

“The Nobel laureate, F.H. Crick has said that if one were to
translate the coded information on one human cell into book form,
one would require one thousand volumes each of five hundred pages to do so.
And yet the mechanism of a cell can copy faithfully at cell division
all this information of one thousand volumes each of
five hundred pages in just twenty minutes.”

–Dr. Wilder-Smith (1976, p. 258).

–=–

“Every organism has in it a store of what is called genetic information… I will refer to an organism’s genetic information store as its Library…. Where is the Library in such a multicellular organism? The answer is everywhere. With a few exceptions every cell in a multicellular organism has a complete set of all the books in the Library. As such an organism grows its cells multiply and in the process the complete central Library gets copied again and again…. The human Library has 46 of these cord-like books in it. They are called chromosomes. They are not all of the same size, but an average one has the equivalent of about 20,000 pages…. Man’s Library, for example, consists of a set of construction and service manuals that run to the equivalent of about a million book-pages together.”

“It is an indication of the sheer complexity of E. coli
that its Library runs to a thousand page-equivalent”

–A.G. Cairns-Smith  (1985, pp. 9,10,11)

 

“The DNA in living cells contains coded information. It is not surprising that so many of the terms used in describing DNA and its functions are language terms. We speak of the genetic code. DNA is transcribed into RNA. RNA is translated into protein. Protein, in a sense, is coded in a foreign language from DNA. RNA could be said to be a dialect of DNA. Such designations are not simply convenient or just anthropomorphisms. They accurately describe the situation.”

–Lester and Bohlin (1984, pp. 85-86)

–=–

Further, consider that human beings have learned to store information on
clay tablets, stone, papyrus, paper, film, cassettes, microchips, etc.
Yet ‘human technology has not yet advanced to the point of
storing information chemically as it is in the DNA molecule

http://apologeticspress.org/APContent.aspx?category=12&article=454

–=–

“It is not possible for a code, of any kind, to arise by chance or accident.
The laws of chance or probability have been worked out by mathematics…
A code is the work of an intelligent mind. Even the cleverest dog or chimpanzee
could not  work out a code of any kind. It is obvious then that chance cannot do it…
This could no more have been the work of chance or accident than could the
“Moonlight Sonata” be played by mice running up and down the keyboard of my piano!
Codes do not arise from chaos”

–Professor Andrews (1978, pp. 28,29).

–=–
Prions:
Infecting The World
Through Vaccination

–=–

So what happens when man comes clumsily and irresponsibly into the age of molecular science, where he begins to intermix species through inoculation? How can man know if his limits truly are what is written in the ancient scriptures and philosophies of moral men unless he seeks the answers by destroying the perfection of nature’s mathematical equations of the biology of life? How can we know the limits of genetically altered life if we don’t push those limits to the very brink of extinction of species, including our own?

Ancient warnings are for pussies!!!

In my previous research, I have postulated the horrifyingly evidence-based theory that all modern disease states, from the dementia’s to cancer to AIDS, have been induced through the vaccination process via the direct bodily injection of foreign “infectious” proteins called prions. Further research has all but confirmed the reality of this notion, showing that the inherent protective foundation of these cellular proteins in cell health (before infection) are essential to life itself.

 

Prion protein aids bone marrow

New study findings point to possible stem cell role for normal form of protein

By Charles Choi | January 31, 2006

The normal form of prion protein (PrP) appears necessary for bone marrow stem cells to renew themselves, scientists reported online this week in the Proceedings of the National Academy of Sciences. These findings suggest a potential physiological function in stem cells for the normal form of the widely expressed protein. “Prior to this work there was no hint that PrP had a function in stem cell biology,” co-author Andrew Steele at the Whitehead Institute for Biomedical Research in Cambridge, Mass., told The Scientist. “We are now looking into PrP function in other adult stem cells, particularly neural stem cells.” Prions are infamous for being associated with transmissible spongiform encephalopathies (TSEs) such as mad cow disease, but the function of PrP — the normal, widespread and highly conserved form of prions — remains a mystery. In preliminary studies, co-author Cheng Cheng Zhang discovered 40% of adult mouse bone marrow cells expressed PrP on their surfaces. More than 80% of these PrP-marked cells were red blood cells or their developmental precursors, suggesting PrP might be a marker for long-term hematopoietic stem cells, which can give rise to the entire adult blood system. To determine if PrP was a marker for long-term hematopoietic stem cells, the researchers took bone marrow cells from wild-type mice and purified them into fractions, some of which expressed PrP. Six months after transplantation into lethally irradiated mice, the researchers saw both short- and long-term engraftment in mice that received PrP-containing cells, but only short-term engraftment activity in mice receiving non-PrP cells. While PrP is a marker for long-term hematopoietic stem cells in wild-type mice, PrP-knockout mice still possess these cells, as well as relatively normal levels of their derived progeny. To determine what function PrP might normally have in hematopoietic stem cells, the researchers carried out several rounds of bone marrow implantations. First they transplanted bone marrow from either wild-type mice or a PrP-null strain into lethally irradiated mice. When the engrafted marrow flourished and generated peripheral blood cells, the researchers implanted the newly reconstituted bone marrow into another lethally irradiated mouse group, then repeated the process a third time. In each round after the first, bone marrow originating from PrP-null mice experienced a dramatically reduced ability to renew itself, while cells from the wild-type mice did not. Retroviral infections that expressed PrP in recipients of PrP-null bone marrow rescued this defective process, suggesting PrP is necessary for hematopoietic stem cell self-renewal. Odile Kellerman at the Pasteur Institute in Paris, who did not participate in this study, noted prions often trigger neuron death in TSEs after long incubation periods,” similarly, PrP only impacted hematopoietic stem cells over the long term. “In both cases, PrP appears to contribute to the long-lasting adaptation of cells to injury,” she told The Scientist. Kellerman suggested that when PrP function is disrupted, cells try to adapt, “but in the long term, this turns out to be detrimental.” The exact mechanism behind how PrP might contribute to hematopoietic stem cell renewal remains unknown. Co-author Harvey Lodish speculated PrP might bond to and concentrate a hormone on the cell surface, or help stem cells adhere to neighboring cells or extracellular matrix. “It should prove fairly straightforward to see if it is adhering to other proteins or any known or unknown hormones,” he told The Scientist. William Stanford at the University of Toronto, who did not participate in this study, noted that PrP is tethered to cell membranes via a glycosylphosphatidylinositol (GPI) anchor, similar to hematopoietic stem cell marker Sca-1. “This suggests these GPI-anchored proteins, which have similar functions, may operate through a common mechanism,” Stanford told The Scientist. Future experiments could investigate whether overexpressing PrP in hematopoietic stem cells increases self-renewal, and rescues self-renewal defects such as in the Sca-1 deficient mouse, Stanford added — or if genetically substituting PrP with a different GPI-anchored protein rescues the self-renewal defect seen in PrP-null mice. cqchoi@nasw.org Links within this article C.C. Zhang et al. “Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal.” PNAS Early Edition.
Published online January 30, 2006. http://www.pnas.org B.A. Maher.
Sources:
“Prion hypothesis proven?” The Scientist, April 21, 2005. http://www.the-scientist.com/article/display/22653/
M. Fogarty. “Prions – The terminators.” The Scientist, July 28, 2003. http://www.the-scientist.com/article/display/13974/
M. Fogarty. “Researchers further define sources of adult blood stem cells.” The Scientist, September 16, 2002. http://www.the-scientist.com/article/display/13257/
J.U. Adams. “The tiniest of life’s rafts.” The Scientist, October 11, 2004 http://www.the-scientist.com/article/display/14978/

–=–

Neurons and Astrocytes Respond to Prion Infection by Inducing Microglia Recruitment

Abstract

The accumulation and activation of microglial cells at sites of amyloid prion deposits or plaques have been documented extensively. Here, we investigate the in vivo recruitment of microglial cells soon after intraocular injection of scrapie-infected cell homogenate (hgtsc+) using immunohistochemistry on retinal sections. A population of CD11b/CD45-positive microglia was specifically detected within the ganglion and internal plexiform retinal cell layers by 2 d after intravitreal injection of hgtsc+. Whereas no chemotactism properties were ascribed to hgtsc+ alone, a massive migration of microglial cells was observed by incubating primary cultured neurons and astrocytes with hgtsc+ in a time- and concentration-dependent manner. hgtsc+ triggered the recruitment of microglial cells by interacting with both neurons and astrocytes by upregulation of the expression levels of a broad spectrum of neuronal and glial chemokines. We show that, in vitro and in vivo, the microglia migration is at least partly under the control of chemokine receptor-5 (CCR-5) activation, because highly specific CCR-5 antagonist TAK-779 significantly reduced the migration rate of microglia. Activated microglia recruited in the vicinity of prion may, in turn, cause neuronal cell damage by inducing apoptosis. These findings provide insight into the understanding of the cell-cell communication that takes place during the development of prion diseases.

Source–> http://www.jneurosci.org/content/24/3/620.full

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Prion hypothesis proven?

In vitro infectivity study in Cell stirs tempest in a test tube

By Brendan Maher (bmaher@the-scientist.com) | April 21, 2005

Protein aggregates generated in a test tube infected wildtype hamsters with a disease much like scrapie, according to an article appearing this week in Cell. Such a demonstration has, in the past, been called the gold standard of proof for the prion hypothesis, Stanley Prusiner’s Nobel-winning assertion that infectious, self-replicating protein isoforms are the culprit in transmissible spongiform encephalopathies (TSEs) like scrapie, Creutzfeldt-Jakob disease, and mad cow disease.

Study coauthor Claudio Soto, said that this demonstration, together with a paper published by Prusiner’s group last summer, should allay most doubts. “There is really little room for skepticism,” he told The Scientist.

But the study has done little to quiet prion hypothesis skeptics. “I’m not going to abandon alternative hypotheses for the time being,” said Robert A. Somerville of the Institute for Animal Health, Edinburgh.

While Prusiner’s group had successfully infected a mouse with a recombinant protein derived from bacteria, some argued that their use of transgenic mice susceptible to the disease undercut the power of the demonstration. In the new study, researchers at the University of Texas Medical Branch, Galveston, Universidad Autonoma, Madrid, and the University of Chile in Santiago fine-tuned a cyclical process for amplifying aggregated protein from an infected hamster brain. Through serial dilutions, they were able to infect a wildtype hamster with in vitro–produced aggregates without any traces of the original infectious brain. But skeptics, including a member of Prusiner’s group, argue that using material from a diseased hamster brain could have resulted in residual contamination.

Soto’s group has been using a process that they call protein misfolding cyclic amplification (PMCA), which aids the aggregation of the normal cellular protein PrPc into the misfolded, polymer-forming PrPres that is associated with TSE pathology. The process works in a fashion similar to polymerase chain reaction (PCR) amplification of oligonucleotides. After seeding PrPc with PrPres, the solution is incubated and sonicated. “Once the aggregates become long enough, we split them into smaller pieces so that in a new conversion, a new incubation, they are able to convert more and more of the normal protein,” Soto explained.

Crucially, however, the PrPres “seed” comes from infected hamster brain homogenate, while the normal PrPc comes from healthy hamster brain homogenate. “They actually started from infectious material, and we didn’t,” said Giuseppe Legname, of the University of California, San Francisco, and co-author on the Prusiner paper. “It’s an alternative approach to demonstrate that you might make prions, but to say that these are synthetic prions, it’s very difficult.”

Soto insisted that serial dilutions between rounds of PMCA reduce scrapie brain homogenate to an amount equivalent to a 10 to the minus 10th and a 10 to the minus 20th–fold dilution. Infectivity generally drops off after 10 to the minus 9th, according to the paper. “We’ve completely ruled out the possibility that the infectivity is still remaining from… the original brain,” Soto said...

Source–> http://www.the-scientist.com/?articles.view/articleNo/23325/title/Prion-hypothesis-proven-/

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While the article continues to criticize the control group results, which you may read at the link above, the important point here is that scientists are creating prions and making them purposefully more infectious. They are testing them in various substances and frequencies. And through the ultra-sound sonic vibration described above as protein misfolding cyclic amplification (PMCA), they are able to excite the growth factor of infectious prions so that they take over (mis-fold) healthy brain tissue much quicker. This PMCA process is used in autopsy to detect prion disease.

I have my own concerns that these ultra-sound frequencies are the same as used in cell-phone towers and in the process of ultra sound for unborn infants and other medical procedures, as well as other frequencies unknown via smart meters, radio waves, etc. We are playing with the fuel for the fire and there is virtually no escaping this permanent state of sonic bombardment…

It is also interesting to note that two men wsere cured of AIDS symptoms by receiving a bone marrow transfusion not so long ago…

(CBS News) Two men who’ve had HIV for years may now be free of the disease following bone marrow transplants, researchers at Brigham and Women’s Hospital in Boston announced Thursday.

The new research has some attendees at the XIX International AIDS Conference in Washington, D.C. hopeful for a cure.

Timothy Ray Brown, man thought to be first “cured” of AIDS, says he’s still cured
Man “cured” of AIDS: Timothy Ray Brown

Both patients were being treated for cases of cancer. One of the patients underwent a bone marrow transplant two years ago at the Dana-Farber/Brigham and Women’s Cancer Center in Boston, the other had the procedure done four years ago at the same hospital. NBCNews.com reports that one of the patients is in his 50s and has been infected since the early 1980s towards the beginning of the AIDS epidemic and the other man, in his 20s, was infected at birth.

Both stayed on their antiretroviral medication regimens, the standard treatment of HIV, following the transplants.

The researchers discovered that overtime as the patients’ cells were replaced by cells from the donor, evidence of HIV in the patients’ blood tests disappeared. The researchers also said both patients have no signs of HIV in their DNA or RNA and levels of their disease-fighting antibodies have also decreased. The researchers think the medications helped allow these cells to be replaced.

“This gives us some important information,” one of the researchers Dr. Daniel Kuritzkes, an infectious disease specialist at the hospital and Harvard Medical school said in a press release. “It suggests that under the cover of antiretroviral therapy, the cells that repopulated the patient’s immune system appear to be protected from becoming re-infected with HIV.”

The researchers themselves won’t call it a cure yet, saying they still need to check more tissues for traces of the disease. But they were surprised to see no signs of HIV beyond what’s seen in a blood test.

We expected HIV to vanish from the patients’ plasma, but it is surprising that we can’t find any traces of HIV in their cells,” said co-resarcher Dr. Timothy Henrich, also of BWH and Harvard. “The next step is to determine if there are any traces of HIV in their tissue.”

The researchers’ announcement comes days after Timothy Ray Brown, the man known as the “Berlin Patient,” held a press conference in Washington, D.C.,  to say he’s still cured of AIDS five years after undergoing a bone marrow blood transplant

Source–> http://www.cbsnews.com/news/bone-marrow-transplant-eliminates-hiv-traces-from-two-patients-dna-call-it-a-cure/

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It is important to note that the chemokine receptor-5 (CCR-5) antagonist prevents the cellular binding of the HIV-1 virus, as is explained in this video:

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And how do these prions effect disease states?

Let’s take for example Multiple Sclerosis:

“The etiology of Multiple Sclerosis (MS) is unknown. Existing epidemiologic data suggests that MS can be an infectious disease. MS used to be classified as one of the ‘slow infections‘–many of these are caused by prions. Prions are small, proteinaceous, infectious particles–distinguished from viruses by the absence of intrinsic nucleic acids. In a contrast to the ‘classic’ prional diseases (Kuru, Scrapie or Creutzfeldt-Jacob Disease) that in CNS affect primarily neurons, the ‘target’ cell in MS is an oligodendrocyte. This may explain differences in disease presentation. This paper presents a pathophysiological model of MS based on the assumption that MS is a prional disease. Processes leading to the demyelination in Multiple Sclerosis seem also to involve lymphocytes, astrocytes and macrophages as well as the interferon system…”

Source: http://www.ncbi.nlm.nih.gov/pubmed/8455467

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NOTE: The protein that prions are made of (PrP) is found throughout the body, even in healthy people and animals, and necessarily protects cells from infections. However, PrP found in infectious material has a different structure and is resistant to proteases, the enzymes (proteins) in the body that can normally break down other proteins. The normal form of the protein is called PrPC, while the infectious form is called PrPSc — the C refers to healthy ‘cellular‘ PrP, while the Sc refers to infectious ‘scrapie‘, the prototypic prion disease, occurring in sheep. The infectious isoform of PrP, known as PrPSc, is able to convert normal PrPC proteins in humans into this infectious isoform by changing their conformation, or shape. This, in turn, alters the way the proteins interconnect, creating symptoms like transmissible spongiform encephalopathy (holes in the human brain like mad cow disease). PrPSc always causes prion disease. In the end, no cellphone call can be made if the interferon protein is infected and mis-folded before it is able to reach its receiving protien that would activate T-Cells or other immune responses. Another word for mis-fold might be easier to understand as to misinform. The immune system is being lied to in a strange, chemically unbalanced way due to prion protein infections (mis-folding). Sheep blood (serum) is a popular vaccine substrate to grow vaccines for humans upon, and the protein and DNA cannot be filtered out of the final vaccine product. There are no other viable explanations why infectious prions from animals would intermingle within a human body (xenotransplantaion/xenografting).

A thorough and sourced description about prions can be found here: http://www.omim.org/entry/176640

This interference that infectious prions cause to interferon and other protein-based signaling and transcription cells is shown in the research studies below. For those with the gumption, let’s play a biological game of connect the dots.

Continued…

RESULTS

Prion infection is accelerated in (interferon type 3) IRF3-deficient mice…

The IRF3-dependent pathway is protective against prion infection in cell culture.

We tested whether over-expression of IRF3 (interferon) could affect the production of PrPSc (infectious/mis-folded prions) in the cell culture models. The level of PrPC (healthy prions) was not affected by the transient expression of the genes in uninfected N2a58 cells (data not shown). PrPSc was significantly decreased by overexpression of IRF3 in the 22L-N2a58 cells (Fig. 5A). We confirmed that the activated form of IRF3 (phosphorylated at Ser396 of IRF3) increases in a dose-dependent manner after transfection of the IRF3 gene in both 22L-N2a58 cells (Fig. 5A) and uninfected N2a58 cells (data not shown), indicating that the upregulation of IRF3 phosphorylation seen in the Fig. 5A is most likely due to an increase in the level of IRF3 protein after transfection.

To investigate the effect of downregulation of IRF3 in the 22L-N2a58 cells, we performed knockdown experiments using small interfering RNAs (siRNAs). IRF3 expression was significantly decreased by two types of siRNAs against IRF3, whereas β-actin expression, as the internal standard, was not changed (Fig. 5B)… These data suggest that IRF3 has an inhibitory effect on the production of PrPSc in the 22L-N2a58 cells.

To further evaluate the protective effect of IRF3… After incubation with 22L-infected BH (22L-BH), the cell clones were subcultured for five passages and analyzed by Western blotting with anti-PrP antibodies. The values of the PrPSc/PrPC ratio were inversely correlated with the values of the IRF3/beta-actin ratio (Fig. 5C), indicating that enhanced expression of IRF3 effectively blocks new prion infection.

DISCUSSION

In the present study, we found that a genetic deficiency of IRF3 accelerates the progression of TSE (transmissable prion disease) following i.p. transmission in mice and that the accumulation rate of PrPSc in the spleen is increased in the IRF3−/− mice. Furthermore, we demonstrated that IRF3 has an inhibitory effect on PrPSc accumulation and that the levels of IRF3 are inversely correlated with resistance to prion infection in cell culture.

IRF3 is known to be constitutively expressed in many tissues and cells (6, 22, 45). Indeed, we confirmed the expression of IRF3 in brains (data not shown) and N2a58 cells (Fig. 5). Furthermore, not only glial cells but also neurons express most innate immunity-related genes and produce type I IFN in response to virus infection (11). Although the role of IRF3 in prion propagation into the CNS is still unclear, we speculate that an absence of IRF3 signaling leads to increased prion replication not only in peripheral tissues but also in the CNS. It would be of great value to examine this further using neuron-specific IRF3-disrupted mice or neuron-specific IRF3-expressing mice.

It was reported in prion infection that genetic disturbance of TLR4 (36) or interleukin-10 (IL-10) (41) leads to shorter incubation periods of prion infection. Since these, respectively, are an upstream and a downstream factor of the IRF3-mediated pathway, the findings may be due in part to functional changes in IRF3-mediated signaling.

Based on these results, two hypothetical models are proposed to explain the inhibitory effect of IRF3 on the prion infection. The first is that MyD88-independent pattern recognition receptors (PRRs), such as TLR3, TLR4, or RIG-I/MDA5, might recognize prion, and the resulting activation of IRF3 could induce various IRF3-responsive genes that may participate in the protective effect. The fact that the in vivo administration of IFNs (interferons), a representative of the IRF3-responsive genes, previously failed to show inhibitory effects on TSE (13, 16) suggests that IRF3-responsive genes other than IFNs may be important for the inhibitory effect of IRF3 on prion infection. Of note, the protective effect of IRF3 against several viruses has been suggested to be largely independent of the production of type I IFN and is probably responsible for the antiviral actions of specific IRF3-responsive genes (10, 18, 21). Peritoneal macrophages from wild-type mice moderately induced tumor necrosis factor alpha (TNF-α) or IL-6 following exposure to PrPSc-mimicking PrP peptides (PrP residues 106 to 126 or PrP residues 118 to 135), whereas TLR4 signaling-mutant mice were impaired in their ability to produce these cytokines (36), supporting in part the hypothesis that some PRRs may sense PrPSc as a sort of PAMP. On the other hand, it should be noted that the MyD88-independent pathway activates both NF-κB and IRF3. Although the induction of proinflammatory cytokines essentially depends upon NF-κB, it was unclear whether the activation of IRF3 was induced by these PrP peptides. In fact, the hallmarks of IRF3 activation, such as phosphorylation, dimerization, and cytoplasm-to-nucleus translocation of IRF3 in 22L-N2a58 cells, were not detected (data not shown). Moreover, it was previously reported that IFNs were not detected in the serum, spleens, or brains of mice infected with scrapie (44). In addition, IFN-β mRNA does not increase in the brains of CJD (human prion disease) patients (7) or mice infected with ME7 prion strain (14). Hence, these results argue against the notion that the IRF3-mediated signaling is activated by prion infection, but it remains to be determined whether transient and weak responses are evoked at an early phase in the infection. The question as to whether IRF3-mediated signaling directly suppresses the production of PrPSc or increases its degradation also remains open.

Another explanation is that prion infection itself may have little effect on the pathway but that the basal activity of IRF3 may have some degree of inhibitory effect on prion propagation. It has been reported that IRF3 can be activated not only by viruses but also by multiple activators such as cellular stress and DNA damage (24, 34). Accordingly, it is possible that constitutive activation of IRF3, albeit at a low level, occurs in the brain even in the absence of a pathogen. This notion is further supported by the fact that constitutive, weak IFN signaling in the absence of viral infection plays a role in modifying cellular responsiveness in the immune and other biological systems (38, 40). Accumulating evidence indicates that many viruses have evolved to evade the innate immune system, including IRF3-mediated signaling (15, 23). For instance, an active mutant of IRF3 has been reported to exert a markedly suppressive effect on cellular HIV-1 infection, and administration of poly(I·C) potently inhibits HIV-1 replication in microglia through a pathway requiring IRF3. Nonetheless, HIV-1 itself does not activate IRF3 but, rather, decreases IRF3 protein in HIV-1-infected cells (12, 37). Likewise, prion infection might disturb the activation of IRF3 even though prion is considered to be largely composed of PrPSc. We are currently investigating this possibility. Furthermore, an analogy can be made between the role of IRF3 in prion infection and that of IL-10. The levels of IL-10 are not increased in the brains of scrapie-infected mice (14, 42), whereas IL-10 knockout mice are highly susceptible to the development of scrapie (41).

In conclusion, we have shown that IRF3, a key transcription factor of the MyD88-independent pathways, operates in the host defense machinery against prion infection. The findings provide new insight into understanding of the innate immunity to prion infection.

Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347345/

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Interleukin-10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, IL-10 is encoded by the IL10 gene.[1]

Gene and protein structure

The IL-10 protein is a homodimer; each of its subunits is 178-amino-acid long.[2]

IL-10 is classified as a class-2 cytokine, a set of cytokines including IL-19, IL-20, IL-22, IL-24 (Mda-7), and IL-26, interferons (IFN-alpha, -beta, -epsilon, -kappa, -omega, -delta, -tau, and -gamma) and interferon-like molecules (limitin, IL-28A, IL-28B, and IL-29).[3]

Expression and synthesis

In humans, IL-10 is encoded by the IL10 gene, which is located on chromosome 1 and comprises 5 exons,[1] and is primarily produced by monocytes and, to a lesser extent, lymphocytes, namely type 2 T helper cells (TH2), mastocytes, CD4+CD25+Foxp3+ regulatory T cells, and in a certain subset of activated T cells and B cells.

In biochemistry, a dimer is a macromolecular complex formed by two, usually non-covalently bound, macromolocules like proteins or nucleic acids. It is a quaternary structure of a protein.

A homo-dimer would be formed by two identical molocules (a process called homodimerization). A hetero-dimer would be formed by two different macromolecules (called heterodimerization).

Most dimers in biochemistry are not connected by covalent bonds. An example of a non-covalent heterodimer would be the enzyme reverse transcriptase, which is composed of two different amino acid chains.[1] An exception is dimers that are linked by disulfide bridges such as the homodimeric protein NEMO.[2]

Some proteins contain specialized domains to ensure dimerization (dimerization domains).

Examples of Homodimer include anti-bodies and Factor VII.

Microglia are a type of glial cell that are the resident macrophages of the brain and spinal chord, and thus act as the first and main form of active immune defense in the central nervous system (CNS).

Microglia constitute 10-15% of the total glial cell population within the brain.[1] Microglia (and astrocytes) are distributed in large non-overlapping regions throughout the brain and spinal cord.[2][3] Microglia are constantly scavenging the CNS for plaques, damaged neurons and infectious agents.[4] The brain and spinal cord are considered “immune privileged” organs in that they are separated from the rest of the body by a series of endothelial cells known as the blood-brain barrier, which prevents most infections from reaching the vulnerable nervous tissue. In the case where infectious agents are directly introduced to the brain or cross the blood–brain barrier, microglial cells must react quickly to decrease inflammation and destroy the infectious agents before they damage the sensitive neural tissue. Due to the unavailability of antibodies from the rest of the body (few antibodies are small enough to cross the blood brain barrier), microglia must be able to recognize foreign bodies, swallow them, and act as antigen-presenting cells activating T-cells. Since this process must be done quickly to prevent potentially fatal damage, microglia are extremely sensitive to even small pathological changes in the CNS.[5] They achieve this sensitivity in part by having unique potassium channels that respond to even small changes in extracellular potassium.

Microglial cells differentiate in the bone marrow from hematopoietic stem cells, the progenitors of all blood cells. During hematopoiesis, some of these stem cells differentiate into monocytes and travel from the bone marrow to the brain, where they settle and further differentiate into microglia.[6]

Monocytes can also differentiate into myeloid dendritic cells and macrophages in the peripheral systems. Like macrophages in the rest of the body, microglia use phagocytic and cytotoxic mechanisms to destroy foreign materials. Microglia and macrophagesboth contribute to the immune response by acting as antigen presenting cells, as well as promoting inflammation and homeostatic mechanisms within the body by secreting cytokines and other signaling molecules.

In their downregulated form, microglia lack the MHC class I/MHC class II proteins, IFN-γ cytokines, CD45 antigens, and many other surface receptors required to act in the antigen-presenting, phagocytic, and cytotoxic roles that hallmark normal macrophages. Microglia also differ from macrophages in that they are much more tightly regulated spatially and temporally in order to maintain a precise immune response.[7]

Another difference between microglia and other cells that differentiate from myeloid progenitor cells is the turnover rate. Macrophages and dendritic cells are constantly being used up and replaced by myeloid progenitor cells which differentiate into the needed type. Due to the blood brain barrier, it would be fairly difficult for the body to constantly replace microglia. Therefore, instead of constantly being replaced with myeloid progenitor cells, the microglia maintain their status quo while in their quiescent state, and then, when they are activated, they rapidly proliferate in order to keep their numbers up. Bone chimera studies have shown, however, that in cases of extreme infection the blood-brain barrier will weaken, and microglia will be replaced with haematogenous, cart-marrow derived cells, namely myeloid progenitor cells and macrophages. Once the infection has decreased the disconnect between peripheral and central systems is reestablished and only microglia are present for the recovery and regrowth period.

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Transport of prion protein across the blood–brain barrier

Abstract

The cellular form of the prion protein (PrPc) is necessary for the development of prion diseases and is a highly conserved protein that may play a role in neuroprotection. PrPc is found in both blood and cerebrospinal fluid and is likely produced by both peripheral tissues and the central nervous system (CNS). Exchange of PrPc between the brain and peripheral tissues could have important pathophysiologic and therapeutic implications, but it is unknown whether PrPc can cross the blood–brain barrier (BBB). Here, we found that radioactively labeled PrPc crossed the BBB in both the brain-to-blood and blood-to-brain directions. PrPc was enzymatically stable in blood and in brain, was cleared by liver and kidney, and was sequestered by spleen and the cervical lymph nodes. Circulating PrPc entered all regions of the CNS, but uptake by the lumbar and cervical spinal cord, hypothalamus, thalamus, and striatum was particularly high. These results show that PrPc has bidirectional, saturable transport across the BBB and selectively targets some CNS regions. Such transport may play a role in PrPc function and prion replication.

Introduction

Cellular prion protein (PrPc) is perhaps best known as a source for the misfolded protein PrPsc (Prusiner, 1997) and as a prerequisite for the development of prion diseases (Mallucci et al., 2000). However, PrPc itself likely has important biological functions. It is found circulating in blood (Volkel et al., 2001) and is found in even higher levels in the cerebrospinal fluid (CSF) (Picard-Hagen et al., 2006). After ischemic events, PrPc levels increase in blood (Mitsios et al., 2007) and in neurons and brain endothelial cells in the peri-infarct region (Mitsios et al., 2007; Weise et al., 2004). These increases may reflect cytoprotective and neuroprotective roles for PrPc as recently reviewed (Roucou & LeBlanc, 2005). PrPc null mice have larger infarct volumes after ischemic events (Weise et al., 2006; Nasu-Nishimura et al., 2008) and more neuronal apoptosis after viral infections (Nasu-Nishimura et al., 2008) than wild type mice. In comparison, mice that overexpress PrPc have smaller infarcts and better neurological outcomes than wild type mice after ischemic events (Shyu et al., 2005). These protective events are likely mediated by PrPc through activation of anti-apoptotic (Spudich et al., 2005) and anti-oxidant pathways (White et al., 1999).

Sources of circulating PrPc likely include platelets (Robertson et al., 2006), endothelial cells (Simak et al., 2002), and lymphocytes (Politopoulou et al., 2000). Among lymphocytes, CD3 and CD8 lymphocytes have especially high levels which increase with aging (Politopoulou et al., 2000). All these cells have membrane bound PrPc that apparently can be released into the circulation. Platelet activation (Robertson et al., 2006) or endothelial apoptosis (Simak et al., 2002), for example, results in release of PrPc from those cells.

Thus, PrPc occurs in both blood and in CSF with levels that are likely responsive to disease states. This raises the question of whether PrPc can cross the blood–brain barrier (BBB). Such passage could link the two pools of PrPc and the events that control their levels. Here, we examined the ability of PrPc to cross the BBB in both the blood-to-brain and the brain-to-blood directions.

Capillary depletion

Capillary depletion as modified for use in the mouse (Triguero et al., 1990; Gutierrez et al., 1993) was used to determine the degree to which PrPc was sequestered and retained by the vascular bed of the brain.

I-PrPc was also taken up by the peripheral tissues of spleen, liver, kidney and cervical lymph nodes (Table 2)… there was a statistically significant decrease in the Ki for brain: F(1,8) = 7.97, p <0.05. This demonstrates that transport of PrPc across the BBB involves a saturable transport system.

Fig. 4 shows values for brain and spinal cord regions. Statistical comparison of the whole brain value to brain regions and olfactory bulb (spinal cord regions excluded) showed a statistically significant variation: F(22,62) = 18.3, p <0.001. The hypothalamus, thalamus, and striatum showed statistically (p <0.01) greater uptake in comparison to whole brain. The highest uptake, however, was into the lumbar region of the spinal cord. Inhibition of uptake by unlabeled PrPc (Table 3; p <0.05) was found for whole brain, olfactory bulb, 4 of the 10 brain regions (occipital cortex, thalamus, striatum, and midbrain) and two of the spinal cord regions (cervical and lumbar)…

Fig. 5 Brain-to-blood efflux of PrPc after icv injection. Half-time clearance from brain was 15.7 min. Inset shows that inclusion of unlabeled PrPc in the icv injection increased retention of radioactively labeled PrPc by brain, demonstrating a saturable component
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Does aluminum in vaccines have a more sinister plot that is stated?

Differential effect of aluminum on the blood-brain barrier transport of peptides, technetium and albumin.

Abstract

Aluminum is a neurotoxin capable of altering membrane structure and function. We investigated whether aluminum also can affect saturable transport across membranes using the blood-brain barrier as our model. Mice were given i.p. or i.v. aluminum (up to 100 mg/kg) as the chloride salt and the disappearance from the brain of several centrally administered substances was measured. We found that aluminum rapidly and profoundly inhibited the saturable system that transports the small, N-tyrosinated peptides Tyr-MIF-1 and the enkephalins from the brain to the blood by acting as a noncompetitive inhibitor. In contrast, the disappearance from the brain of technetium pertechnetate (a substance also transported out of the brain by a different saturable system), albumin or D-Tyr-MIF-1 (a stereoisomer of Tyr-MIF-1 that was confirmed not to be transported by the carrier system) was not affected by aluminum. Aluminum also did not alter either the saturable or nonsaturable component of the uptake of Tyr-MIF-1 by erythrocytes. These findings suggest that one mechanism by which aluminum may induce neurotoxicity is by selective alteration of the transport systems of the blood-brain barrier.

Source: http://www.ncbi.nlm.nih.gov/pubmed/2894456

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An enkephalin is a pentapeptide involved in regulating nociception in the body. The enkephalins are termed endogenous ligands, as they are internally derived and bind to the body’s opioid receptors. Discovered in 1975, two forms of enkephalin were revealed, one containing leucine (“leu”), and the other containing mathione (“met”). Both are products of the proenkephalin gene.

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Endogenous opioid peptides

There are three well-characterized families of opioid peptides produced by the body: enkephalins, endorphines, and dynorphins. The met-enkephalin peptide sequence is coded for by the enkephalin gene; the leu-enkephalin peptide sequence is coded for by both the enkephalin gene and the dynorphin gene.[3] The proopiomelanocortin gene (POMC) also contains the met-enkephalin sequence on the N-terminus of beta-endorphin, but the endorphin peptide is not processed into enkephalin.

Enkephalin receptor

Main article: Opioid recepter
The receptors for enkephalin are the delta opioid receptors. Opioid receptors are a group of G-protein-coupled receptors, with other opioids as ligands as well. The other endogenous opioids are dynorphins (that bind to kappa receptors), endorphines (mu receptors), endomorphins, and nociceptin/orphanin FQ. The opioid receptors are ~40% identical to somatostatin receptors (SSTRs).

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Endomorphins, Met-Enkephalin, Tyr-MIF-1, and the P-glycoprotein Efflux System

Abstract

The P-glycoprotein (P-gp) transport system, responsible for the efflux of many therapeutic drugs out of the brain, recently has been shown to transport the endogenous brain opiate endorphin. We used P-gp knockout mice (Mdr1a) and their controls to determine where P-gp is involved in the saturable efflux systems of four other endogenous opiate-modulating peptides across the blood-brain barrier (BBB). After injection of endomorphin-1 (Tyr-Pro-Trp-Phe-NH2), endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), Met-enkephalin (Tyr-Gly-Gly-Phe-Met-OH), and Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) into the lateral ventricle of the mouse brain, residual radioactivity was measured at 0, 2, 5, 10, and 20 min later. The results showed no difference in the disappearance of any of these peptides from the brains of knockout mice compared with their controls. This demonstrates that unlike endorphin and morphine, P-gp does not seem to be required for the brain-to-blood transport of the endomorphins, Met-enkephalin, or Tyr-MIF-1 across the BBB.

Footnotes

  • This work was supported by the United States Army Medical Research Acquisition Activity (DAMD17-00-0113) and the Department of Veterans Affairs.

Source: http://dmd.aspetjournals.org/content/30/3/231.abstract

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Endorphins (“endogenous morphine”) are endogenous opioid inhibitory neuropeptides. They are produced by the central nervous system and pituitary gland. The term implies a pharmacological activity (analogous to the activity of the corticosteroid category of biochemicals) as opposed to a specific chemical formulation. It consists of two parts: endo- and -orphin; these are short forms of the words endogenous and morphine, intended to mean “a morphine-like substance originating from within the body.”[1]

History

Opioid neuropeptides were first discovered in 1974 by two independent groups of investigators:

  • John Hughes and Hans Kosterlitz of Scotland isolated — from the brain of a pig — what some called enkephalins (from the Greek εγκέφαλος, cerebrum).[2][3]
  • Around the same time, in a calf brain, Rabi Simantov and Solomon H. Snyder of the United States found[4] what Eric Simon (who independently discovered opioid receptors in vertebral brains) later termed “endorphin” by an abreviation of of “endogenous morphine”, meaning “morphine produced naturally in the body”.[1] Importantly, recent studies have demonstrated that human and diverse animal tissues are in fact capable of producing morphine itself, which is not a peptide.[5][6]

Mechanism of action

Beta-endorphin (β-endorphin) is released into blood from the pituitary gland and into the spinal cord and brain from hypothalamic neurons. The β-endorphin that is released into the blood cannot enter the brain in large quantities because of the blood-brain barrier, so the physiological importance of the β-endorphin that can be measured in the blood is far from clear. β-endorphin is a cleavage product of pro-opiomelanocortin (POMC), which is also the precursor hormone for adrenocorticotrophic hormone (ACTH). The behavioural effects of β-endorphin is exerted by its actions in the brain and spinal cord, and it is presumed that the hypothalamic neurons are the major source of β-endorphin at those sites. In situations where the level of ACTH is increased (e.g., Cushing’s disease), the level of β-endorphin also increases slightly.

β-endorphin has the highest affinity for the μ1 opioid receptor, slightly lower affinity for the μ2 and δ opioid receptors, and low affinity for the κ1 opioid receptors. μ-Opioid receptors are the main receptor through which morphine acts. In the classical sense, μ opioid receptors are presynaptic, and inhibit neurotransmitter release. Through that mechanism, they inhibit the release of the inhibitory neurotransmitter GABA, and disinhibit the dopamine pathways, causing more dopamine to be released. By hijacking this process, exogenous opioids cause inappropriate dopamine release, and can lead to aberrant synaptic plasticity, which can cause dependency. Opioid receptors have many other and more important roles in the brain and periphery; however, modulating pain, cardiac, gastric and vascular function as well as possibly panic and satiation. Also, receptors are often found at postsynaptic locations as well as at presynaptic locations…

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Morphine preconditioning reduces lipopolysaccharide and interferon-γ-induced mouse microglial cell injury via δ1 opioid receptor activation

Abstract

Microglial cells play an important role in the inflammatory response of a broad range of brain diseases including stroke, brain infection and neurodegenerative diseases. However, there is very little information regarding how to protect microglial cells. Here, we showed that incubation of the C8-B4 mouse microglial cells with lipopolysaccharide (LPS) plus interferon-γ (IFNγ) induced cytotoxicity as assessed by the amount of lactate dehydrogenase (LDH) released from the cells. Preconditioning the cells with morphine for 30 min concentration-dependently reduced LPS plus IFNγ-induced cell injury. This morphine preconditioning effect was abolished by naloxone, a general opioid receptor antagonist, by naltrindole, a selective δ opioid receptor antagonist and by 7-benzylidenenaltrexone maleate, a selective δ1 opioid receptor antagonist. However, this protective effect was not affected by β-funaltrexamine, a selective μ opioid receptor antagonist, nor-binaltorphimine, a selective κ opioid receptor antagonist or naltriben, a selective δ2 opioid receptor antagonist. LPS plus IFNγ induced the expression of inducible nitric oxide synthase (iNOS), which was not affected by morphine preconditioning. Our results suggest that morphine induced a preconditioning effect in microglial cells. This effect may be mediated by δ1 opioid receptors and may not be through inhibiting the expression of iNOS, a potentially harmful protein.

Source–> http://www.sciencedirect.com/science/article/pii/S0306452210002137

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Prion peptide PrP106-126 induces inducible nitric oxide synthase (iNOS) and proinflammatory cytokine gene expression through the activation of NF-kB in macrophage cells

The inflammatory response in prion diseases is dominated by microglia activation. The molecular mechanisms that lie behind this inflammatory process are not very well understood. In the present study, we examined the activation of nuclear factor-kappa B (NF-κB) upon exposure to PrP106-126 and its role in PrP106-126-induced upregulation of inducible nitric oxide synthase (iNOS) and proinflammatory cytokines (interleukin [IL]-1β, tumor necrosis factor [TNF]-α, IL-6) in Ana-1 macrophages. The results showed that iNOS and proinflammatory cytokine release was significantly elevated in Ana-1 macrophages upon exposure to PrP106-126; that PrP106-126 treatment led to a significant NF-κB activation; that proinflammatory cytokines gene expression was elevated in macrophages upon exposure to PrP106-126; and that NF-κB inhibition significantly abrogated PrP106-126-induced upregulation of iNOS and inflammatory cytokine mRNA expression. These results suggest that treatment with neurotoxic prion peptides leads to the activation of transcription factor NF-κB, which in turn stimulates gene expression of iNOS and proinflammatory cytokines in Ana-1 macrophages.

Source–> http://www.pubfacts.com/detail/22149924/Prion-peptide-PrP106-126-induces-inducible-nitric-oxide-synthase-and-proinflammatory-cytokine-gene-e

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The Transcription Factor Nuclear Factor-kappa B and Cancer

Abstract

Since the discovery of nuclear factor-kappa B (NF-κB) in 1986, many studies have been conducted showing the link between the NF-κB signalling pathway and control of the inflammatory response. Today it is well known that control of the inflammatory response and apoptosis is closely related to the activation of NF-κB. Three NF-κB activation pathways exist. The first (the classical pathway) is normally triggered in response to microbial and viral infections or exposure to pro-inflammatory cytokines that activate the tripartite IKK complex, leading to phosphorylation-induced IκB degradation and depends mainly on IKKβ activity. The second (the alternative pathway), leads to selective activation of p52:RelB dimers by inducing the processing of the NF-κB2/p100 precursor protein, which mostly occurs as a heterodimer with RelB in the cytoplasm. This pathway is triggered by certain members of the tumour necrosis factor cytokine family, through selective activation of IKKα homodimers by the upstream kinase NIK. The third pathway is named CK2 and is IKK independent. NF-κB acts through the transcription of anti-apoptotic proteins, leading to increased proliferation of cells and tumour growth. It is also known that some drugs act directly in the inhibition of NF-κB, thus producing regulation of apoptosis; some examples are aspirin and corticosteroids. Here we review the role of NF-κB in the control of apoptosis, its link to oncogenesis, the evidence of several studies that show that NF-κB activation is closely related to different cancers, and finally the potential target of NF-κB as cancer therapy.

Source–> http://www.sciencedirect.com/science/article/pii/S0936655506004274

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Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology

Highlights

• NF-κB signaling in MS patients and animal models of MS.
NF-κB signaling controls peripheral immune activation at multiple levels.
NF-κB controls inflammatory responses locally in the CNS.
• NF-κB as a therapeutic target for the treatment of MS.

The nuclear factor kappa B (NF-κB) signaling cascade plays a critical role in the regulation of immune and inflammatory responses and has been implicated in the pathogenesis of autoimmune demyelinating diseases such as multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), the main animal model of MS. NF-κB is essential for peripheral immune cell activation and the induction of pathology, but also plays crucial roles in resident cells of the central nervous system (CNS) during disease development. Here we review recent evidence clarifying the role of NF-κB in the different cell compartments contributing to MS pathology and its implications for the development of therapeutic strategies for the treatment of MS and other demyelinating pathologies of the CNS.

Source–> http://www.sciencedirect.com/science/article/pii/S1471491413001330

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NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet radiation, oxidized LDL, and bacterial or viral antigens.[1][2][3][4][5] NF-κB plays a key role in regulating the immune response to infection (k light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory, and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.[6][7][8][9][10]

In brief, NF-κB can be understood to be a protein responsible for cytokine production and cell survival.

Structure

All proteins of the NF-κB family share a Rel homology domain in their N-terminus. A subfamily of NF-κB proteins, including RelA, RelB, and c-Rel, have a transactivation domain in their C-termini. In contrast, the NF-κB1 and NF-κB2 proteins are synthesized as large precursors, p105, and p100, which undergo processing to generate the mature NF-κB subunits, p50 and p52, respectively. The processing of p105 and p100 is mediated by the ubiquitin/proteasome pathway and involves selective degradation of their C-terminal region containing ankyrin repeats. Whereas the generation of p52 from p100 is a tightly regulated process, p50 is produced from constitutive processing of p105.[12][13] The p50 and p52 proteins have no intrinsic ability to activate transcription and thus have been proposed to act as transcriptional repressors when binding κB elements as homodimers.[14][15] Indeed, this confounds the interpretation of p105-knockout studies, where the genetic manipulation is removing an IκB (full-length p105) and a likely repressor (p50 homodimers) in addition to a transcriptional activator (the RelA-p50 heterodimer).

Members

NF-κB family members share structural homology with the retroviral oncoprotein v-Rel, resulting in their classification as NF-κB/Rel proteins.[1]

There are five proteins in the mammalian NF-κB family:[16]

Species distribution and evolution

In addition to mammals, NF-κB is found in a number of simple animals as well.[17] These include cnidarians (such as sea anemones, coral and hydra), porifera (sponges), the single-celled eukaryote Capsaspora owczarzaki and insects (such as moths, mosquitoes, and fruit flies). The sequencing of the genomes of the mosquitoes A. aegypti and A. gambiae, and the fruitfly D. melangaster has allowed comparative genetic and evolutionary studies on NF-κB. In those insect species, activation of NF-κB is triggered by the Toll pathway (which evolved independently in insects and mammals) and by the Imd (immune deficiency) pathway.[18]

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors usually expressed in sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes. Once these microbes have breached physical barriers such as the skin or intestinal tract mucosa, they are recognized by TLRs, which activate immune cell responses

Signaling

Activation

NF-κB (green) heterodimerizes with RelB (cyan) to form a ternary complex with DNA (orange) that promotes gene transcription.[19]

NF-κB is important in regulating cellular responses because it belongs to the category of “rapid-acting” primary transcription factors, i.e., transcription factors that are present in cells in an inactive state and do not require new protein synthesis in order to become activated (other members of this family include transcription factors such as c-Jun, STATs, and nuclear hormone receptors). This allows NF-κB to be a first responder to harmful cellular stimuli. Known inducers of NF-κB activity are highly variable and include reactive oxygen species (ROS), tumor necrosis factor alpha (TNFa), interleukin 1-beta (IL1β), bacterial lipopolysaccharides (LPS), isoproterenol, cocaine, and ionizing radiation.[20]

Receptor activator of NF-κB (RANK), which is a type of TNFR, is a central activator of NF-κB. Osteoprotegerin (OPG), which is a decoy receptor homolog for RANK ligand, inhibits RANK by binding to RANKL, and, thus, osteoprotegerin is tightly involved in regulating NF-κB activation.[21]

Many bacterial products and stimulation of a wide variety of cell-surface receptors lead to NF-κB activation and fairly rapid changes in gene expression.[1] The identification of Toll-like receptors(TLRs) as specific pattern recognition molecules and the finding that stimulation of TLRs leads to activation of NF-κB improved our understanding of how different pathogens activate NF-κB. For example, studies have identified TLR4 as the receptor for the LPS component of Gram-negative bacteria.[22] TLRs are key regulators of both innate and adaptive immune responses.[23]

Unlike RelA, RelB, and c-Rel, the p50 and p52 NF-κB subunits do not contain transactivation domains in their C terminal halves. Nevertheless, the p50 and p52 NF-κB members play critical roles in modulating the specificity of NF-κB function. Although homodimers of p50 and p52 are, in general, repressors of κB site transcription, both p50 and p52 participate in target gene transactivation by forming heterodimers with RelA, RelB, or c-Rel.[24] In addition, p50 and p52 homodimers also bind to the nuclear protein Bcl-3, and such complexes can function as transcriptional activators.[25][26][27]

Inhibition

In unstimulated cells, the NF-κB dimers are sequestered in the cytoplasm by a family of inhibitors, called IκBs (Inhibitor of κB), which are proteins that contain multiple copies of a sequence called ankyrin repeats. By virtue of their ankyrin repeat domains, the IκB proteins mask the nuclear localization signals (NLS) of NF-κB proteins and keep them sequestered in an inactive state in the cytoplasm.[28]

IκBs are a family of related proteins that have an N-terminal regulatory domain, followed by six or more ankyrin repeats and a PEST domain near their C terminus. Although the IκB family consists of IκBα, IκBβ, IκBε, and Bcl-3, the best-studied and major IκB protein is IκBα. Due to the presence of ankyrin repeats in their C-terminal halves, p105 and p100 also function as IκB proteins. The c-terminal half of p100, that is often referred to as IκBδ, also functions as an inhibitor.[29][30] IκBδ degradation in response to developmental stimuli, such as those transduced through LTβR, potentiate NF-κB dimer activation in a NIK dependent non-canonical pathway.[29][31]

Activation of the NF-κB is initiated by the signal-induced degradation of IκB proteins. This occurs primarily via activation of a kinase called the IκB kinase (IKK). IKK is composed of a heterodimer of the catalytic IKKα and IKKβ subunits and a “master” regulatory protein termed NEMO (NF-κB essential modulator) or IKK gamma. When activated by signals, usually coming from the outside of the cell, the IκB kinase phosphorylates two serine residues located in an IκB regulatory domain. When phosphorylated on these serines (e.g., serines 32 and 36 in human IκBα), the IκB inhibitor molecules are modified by a process called ubiquitination, which then leads them to be degraded by a cell structure called the proteasome.

With the degradation of IκB, the NF-κB complex is then freed to enter the nucleus where it can ‘turn on’ the expression of specific genes that have DNA-binding sites for NF-κB nearby. The activation of these genes by NF-κB then leads to the given physiological response, for example, an inflammatory or immune response, a cell survival response, or cellular proliferation. NF-κB turns on expression of its own repressor, IκBα. The newly synthesized IκBα then re-inhibits NF-κB and, thus, forms an auto feedback loop, which results in oscillating levels of NF-κB activity.[32] In addition, several viruses, including the AIDS virus HIV, have binding sites for NF-κB that controls the expression of viral genes, which in turn contribute to viral replication or viral pathogenicity. In the case of HIV-1, activation of NF-κB may, at least in part, be involved in activation of the virus from a latent, inactive state.[33] YopP is a factor secreted by Yersinia pestis, the causative agent of plague, that prevents the ubiquitination of IκB. This causes this pathogen to effectively inhibit the NF-κB pathway and thus block the immune response of a human infected with Yersinia.[34]

Inhibitors of NF-κB activity

Concerning known protein inhibitors of NF-κB activity, one of them is IFRD1, which represses the activity of NF-κB p65 by enhancing the HDAC-mediated deacetylation of the p65 subunit at lysine 310, by favoring the recruitment of HDAC3 to p65. In fact IFRD1 forms trimolecular complexes with p65 and HDAC3.[35][36]

Non-canonical

A select set of cell-differentiating or developmental stimuli, such as lymphotoxin-α, BAFF or RANKL, activate the non-canonical NF-κB pathway to induce NF-κB/RelB:p52 dimer in the nucleus. In this pathway, activation of the NF-κB inducing kinase (NIK) upon receptor ligation led to the phosphorylation and subsequent proteasomal processing of the NF-κB2 precursor protein p100 into mature p52 subunit in an IKK1/IKKa dependent manner. Then p52 dimerizes with RelB to appear as a nuclear RelB:p52 DNA binding activity and regulate a distinct class of genes.[37] In contrast to the canonical signaling that relies upon NEMO-IKK2 mediated degradation of IκBα, -β, -ε, the non-canonical signaling critically depends on NIK mediated processing of p100 into p52. Given their distinct regulations, these two pathways were thought to be independent of each other. However, recent analyses revealed that synthesis of the constituents of the non-canonical pathway, viz RelB and p52, is controlled by the canonical IKK2-IκB-RelA:p50 signaling.[38] Moreover, generation of the canonical and non-canonical dimers, viz RelA:p50 and RelB:p52, within the cellular milieu are also mechanistically interlinked.[38] These analyses suggest that an integrated NF-κB system network underlies activation of both RelA and RelB containing dimer and that a malfunctioning canonical pathway will lead to an aberrant cellular response also through the non-canonical pathway.

In immunity

NF-κB is a major transcription factor that regulates genes responsible for both the innate and adaptive immune response. Upon activation of either the T- or B-cell receptor, NF-κB becomes activated through distinct signaling components. Upon ligation of the T-cell receptor, protein kinase Lck is recruited and phosphorylates the ITAMs of the CD3 cytoplasmic tail. ZAP70 is then recruited to the phosphorylated ITAMs and helps recruit LAT and PLC-γ, which causes activation of PKC. Through a cascade of phosphorylation events, the kinase complex is activated and NF-κB is able to enter the nucleus to upregulate genes involved in T-cell development, maturation, and proliferation.[39]

In the nervous system

In addition to roles in mediating cell survival, studies by Mark Mattson and others have shown that NF-κB has diverse functions in the nervous system including roles in plasticity, learning, and memory. In addition to stimuli that activate NF-κB in other tissues, NF-κB in the nervous system can be activated by Growth Factors (BDNF, NGF) and synaptic transmission such as glutamate.[7] These activators of NF-κB in the nervous system all converge upon the IKK complex and the canonical pathway.

Recently there has been a great deal of interest in the role of NF-κB in the nervous system. Current studies suggest that NF-κB is important for learning and memory in multiple organisms including crabs,[9][10] fruit flies,[40] and mice.[7][8] NF-κB may regulate learning and memory in part by modulating synaptic plasticity,[6][41] synapse function,[40][42][43] as well as by regulating the growth of dendrites[44] and dendritic spines.[43]

Genes that have NF-κB binding sites are shown to have increased expression following learning,[8] suggesting that the transcriptional targets of NF-κB in the nervous system are important for plasticity. Many NF-κB target genes that may be important for plasticity and learning include growth factors (BDNF, NGF)[45] cytokines (TNF-alpha, TNFR)[46] and kinases (PKAc).[41]

Despite the functional evidence for a role for Rel-family transcription factors in the nervous system, it is still not clear that the neurological effects of NF-κB reflect transcriptional activation in neurons. Most manipulations and assays are performed in the mixed-cell environments found in vivo, in “neuronal” cell cultures that contain significant numbers of glia, or in tumor-derived “neuronal” cell lines. When transfections or other manipulations have been targeted specifically at neurons, the endpoints measured are typically electrophysiology or other parameters far removed from gene transcription. Careful tests of NF-κB-dependent transcription in highly purified cultures of neurons generally show little to no NF-κB activity.[47][48] Some of the reports of NF-κB in neurons appear to have been an artifact of antibody nonspecificity.[49] Of course, artifacts of cell culture—e.g., removal of neurons from the influence of glia—could create spurious results as well. But this has been addressed in at least two coculture approaches. Moerman et al.[50] used a coculture format whereby neurons and glia could be separated after treatment for EMSA analysis, and they found that the NF-κB induced by glutamatergic stimuli was restricted to glia (and, intriguingly, only glia that had been in the presence of neurons for 48 hours). The same investigators explored the issue in another approach, utilizing neurons from an NF-κB reporter transgenic mouse cultured with wild-type glia; glutamatergic stimuli again failed to activate in neurons.[51] Some of the DNA-binding activity noted under certain conditions (particularly that reported as constitutive) appears to result from Sp3 and Sp4 binding to a subset of κB enhancer sequences in neurons.[52] This activity is actually inhibited by glutamate and other conditions that elevate intraneuronal calcium. In the final analysis, the role of NF-κB in neurons remains opaque due to the difficulty of measuring transcription in cells that are simultaneously identified for type. Certainly, learning and memory could be influenced by transcriptional changes in astrocytes and other glial elements. And it should be considered that there could be mechanistic effects of NF-κB aside from direct transactivation of genes.

Clinical significance

Overview of signal transduction pathways involved in apoptosis.

Cancers

NF-κB is widely used by eukaryotic cells as a regulator of genes that control cell proliferation and cell survival. As such, many different types of human tumors have misregulated NF-κB: that is, NF-κB is constitutively active. Active NF-κB turns on the expression of genes that keep the cell proliferating and protect the cell from conditions that would otherwise cause it to die via apoptosis.

Defects in NF-κB results in increased susceptibility to apoptosis leading to increased cell death. This is because NF-κB regulates anti-apoptotic genes especially the TRAF1 and TRAF2 and, therefore, checks the activities of the caspase family of enzymes, which are central to most apoptotic processes.[53]

In tumor cells, NF-κB is active either due to mutations in genes encoding the NF-κB transcription factors themselves or in genes that control NF-κB activity (such as IκB genes); in addition, some tumor cells secrete factors that cause NF-κB to become active. Blocking NF-κB can cause tumor cells to stop proliferating, to die, or to become more sensitive to the action of anti-tumor agents. Thus, NF-κB is the subject of much active research among pharmaceutical companies as a target for anti-cancer therapy.[54]

However, caution should be exercised when considering anti-NF-κB activity as a broad therapeutic strategy in cancer therapy, even though convincing experimental data have identified NF-κB as a critical promoter of cancer development, creating a solid rationale for the development of antitumor therapy that suppresses NF-κB activity. Data have also shown that NF-κB activity enhances tumor cell sensitivity to apoptosis and senescence. In addition, it has been shown that canonical NF-κB is a Fas transcription activator and the alternative NF-κB is a Fas transcription repressor.[55] Therefore, NF-κB promotes Fas-mediated apoptosis in cancer cells, and thus inhibition of NF-κB may suppress Fas-mediated apoptosis to impair host immune cell-mediated tumor suppression.

Inflammation

Because NF-κB controls many genes involved in inflammation, it is not surprising that NF-κB is found to be chronically active in many inflammatory diseases, such as inflammatory bowel disease, arthritis, sepsis, gastritis, asthma, atherosclerosis[56] and others. It is important to note though, that elevation of some NF-κB inhibitors, such as osteoprotegerin (OPG), are associated with elevated mortality, especially from cardiovascular diseases.[57][58] Elevated NF-κB has also been associated with schizophrenia.[59] Recently, NF-κB activation has been suggested as a possible molecular mechanism for the catabolic effects of cigarette smoke in skeletal muscle and sarcopenia.[60]

Non-drug inhibitors

Many natural products (including anti-oxidants) that have been promoted to have anti-cancer and anti-inflammatory activity have also been shown to inhibit NF-κB.[61][62] There is a controversial US patent (US patent 6,410,516)[63] that applies to the discovery and use of agents that can block NF-κB for therapeutic purposes. This patent is involved in several lawsuits, including Ariad v. Lilly. Recent work by Karin,[64] Ben-Neriah[65] and others has highlighted the importance of the connection between NF-κB, inflammation, and cancer, and underscored the value of therapies that regulate the activity of NF-κB.[66]

Extracts from a number of herbs and dietary plants are efficient inhibitors of NF-κB activation in vitro.[67][68][69]

The circumsporozoite protein of Plasmodium falciparum has been shown to be an inhibitor of NF-κB.[70]

As a drug target

Aberrant activation of NF-κB is frequently observed in many cancers. Moreover, suppression of NF-κB limits the proliferation of cancer cells. In addition, NF-κB is a key player in the inflammatory response. Hence methods of inhibiting NF-κB signaling has potential therapeutic application in cancer and inflammatory diseases.[71][72]

The discovery that activation of NF-κB nuclear translocation can be separated from the elevation of oxidant stress[73] gives an important hint to the development of strategies for NF-κB inhibition.

A new drug called denosumab acts to raise bone mineral density and reduce fracture rates in many patient sub-groups by inhibiting RANKL. RANKL acts through its receptor RANK, which in turn promotes NF-κB,[74] RANKL normally works by enabling the differentiation of osteoclasts from monocytes.

Disulfiram, olmesartan and dithiocarbamates can inhibit the nuclear factor-κB (NF-κB) signaling cascade.[75]

Anatabine’s antiinflammatory effects are claimed to result from modulation of NF-κB activity.[76] However the studies purporting its benefit use abnormally high doses in the millimolar range (similar to the extracellular potassium concentration), which are unlikely to be achieved in humans.

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NF-kB

Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene.[1]

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S  proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappaB (NF-kB) protein complex. NF-κB is a transcription factor that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NF-κB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions; over 200 known genes are targets of NF-κB in various cell types, under specific conditions. Inappropriate activation of NF-κB has been associated with a number of inflammatory diseases while persistent inhibition of NF-κB leads to inappropriate immune cell development or delayed cell growth.[2]

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Signal Transduction Through Prion Protein

The cellular prion protein PrPc is a glycosylphosphatidylinositol-anchored cell-surface protein whose biological function is unclear. We used the murine 1C11 neuronal differentiation model to search for PrPc-dependent signal transduction through antibody-mediated cross-linking. A caveolin-1–dependent coupling of PrPc to the tyrosine kinase Fyn was observed. Clathrin might also contribute to this coupling. The ability of the 1C11 cell line to trigger PrPc-dependent Fyn activation was restricted to its fully differentiated serotonergic or noradrenergic progenies. Moreover, the signaling activity of PrPc occurred mainly at neurites. Thus, PrPc may be a signal transduction protein.

Science 15 September 2000:
Vol. 289
no. 5486 pp. 19251928
DOI:10.1126/science.289.5486.1925
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A cellular gene encodes scrapie PrP 27-30 protein.

Abstract

A clone encoding PrP 27-30, the major protein in purified preparations of scrapie agent, was selected from a scrapie-infected hamster brain cDNA library by oligonucleotide probes corresponding to the N terminus of the protein. Southern blotting with PrP cDNA revealed a single gene with the same restriction patterns in normal and scrapie-infected brain DNA. A single PrP-related gene was also detected in murine and human DNA. PrP-related mRNA was found at similar levels in normal and scrapie-infected hamster brain, as well as in many other normal tissues. Using antisera against PrP 27-30, a PrP-related protein was detected in crude extracts of infected brain and to a lesser extent in extracts of normal brain. Proteinase K digestion yielded PrP 27-30 in infected brain extract, but completely degraded the PrP-related protein in normal brain extract. No PrP-related nucleic acids were found in purified preparations of scrapie prions, indicating that PrP 27-30 is not encoded by a nucleic acid carried within the infectious particles.

Source–> http://www.ncbi.nlm.nih.gov/pubmed/2859120

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Identification of Chemoattractive Factors Involved in the Migration of Bone Marrow-Derived Mesenchymal Stem Cells to Brain Lesions Caused by Prions

ABSTRACT

Bone marrow-derived mesenchymal stem cells (MSCs) have been reported to migrate to brain lesions of neurodegenerative diseases; however, the precise mechanisms by which MSCs migrate remain to be elucidated. In this study, we carried out an in vitro migration assay to investigate the chemoattractive factors for MSCs in the brains of prion-infected mice. The migration of immortalized human MSCs (hMSCs) was reduced by their pretreatment with antibodies against the chemokine receptors, CCR3, CCR5, CXCR3, and CXCR4 and by pretreatment of brain extracts of prion-infected mice with antibodies against the corresponding ligands, suggesting the involvement of these receptors, and their ligands in the migration of hMSCs. In agreement with the results of an in vitro migration assay, hMSCs in the corpus callosum, which are considered to be migrating from the transplanted area toward brain lesions of prion-infected mice, expressed CCR3, CCR5, CXCR3, and CXCR4. The combined in vitro and in vivo analyses suggest that CCR3, CCR5, CXCR3, and CXCR4, and their corresponding ligands are involved in the migration of hMSCs to the brain lesions caused by prion propagation. In addition, hMSCs that had migrated to the right hippocampus of prion-infected mice expressed CCR1, CX3CR1, and CXCR4, implying the involvement of these chemokine receptors in hMSC functions after chemotactic migration. Further elucidation of the mechanisms that underlie the migration of MSCs may provide useful information regarding application of MSCs to the treatment of prion diseases.

INTRODUCTION

Prion diseases are fatal neurodegenerative disorders in humans and animals that are characterized by the accumulation of a disease-specific isoform of the prion protein (PrPSc), astrocytosis, microglial activation, spongiosis, and neuronal cell death in the central nervous system (CNS). Although the etiology of the diseases is not clear, conversion of the normal prion protein to PrPSc plays a key role in the neuropathological changes (44). Therefore, compounds that inhibit PrPSc formation are considered as therapeutic candidates of the diseases, and many compounds have been reported to inhibit PrPSc formation in cell cultures and cell-free systems (reviewed in reference 56). However, only a few of these inhibitors, such as amphotericin B and its derivative (13), pentosan polysulfate (14), porphyrin derivatives (27), certain amyloidophilic compounds (25), and FK506 (37) have been reported to prolong the survival of prion-infected mice even when administered in the middle-late stage of infection but still before clinical onset. We recently reported that intraventricular infusion of anti-PrP antibodies (50) slowed down the progression of the disease even when initiated just after clinical onset. However, in addition to inhibition of PrPSc formation, the protection of neurons or restoration of degenerated neurons is thought to be important for functional recovery.

Bone marrow-derived mesenchymal stem cells (MSCs) differentiate into cells of mesodermal origin such as adipocytes, osteoblasts, and endothelial and muscle cells (41, 43). In addition, MSCs are known to transdifferentiate into neuronal and glial cells. MSCs have been shown to migrate to damaged neuronal tissues and to alleviate the deficits in experimental animal models of cerebral ischemia (10), spinal cord injury (20), Parkinson’s disease (19, 33), and amyotrophic lateral sclerosis (59). MSCs also secrete various neurotrophic factors that may protect neuronal tissues from degradations, as well as stimulate the activity of endogenous neural stem cells (38). Therefore, despite their mesodermal origin, MSCs are considered to be a candidate for cell-mediated therapy for neurodegenerative diseases. One of the characteristics of MSCs is their migration to brain lesions caused by neurodegenerative diseases, including prion diseases (10, 19, 39, 51). This feature may be of further use for cell-mediated therapy of neurodegenerative diseases, particularly for prion diseases, Multiple sclerosis and Alzheimer’s disease, which have diffuse pathological lesions.

Since many cytokines, chemokines, and adhesion molecules are involved in the homing of immune cells (9, 36, 53), evidence that a variety of chemokines and growth factors, as well as their cognate receptors, have a pivotal role in the migration of MSCs has been accumulated. These factors include CXCL12 and its receptor CXCR4 (30, 40; reviewed in reference 52), CCL2 (15, 62, 66), CCL3 (62), interleukin-8 (48, 62), hepatocyte growth factor (16), platelet-derived growth factor AB (PDGF-AB), insulin-like growth factor 1 (IGF-1), CCL5 and CCL22 (42), and integrin β1 (23). Regarding the migration of MSCs to injury in the CNS, the involvement of CCL2 (61), CXCL12/CXCR4, and CX3CL1/CX3CR1 (24) has been reported. However, knowledge of the mechanism by which MSCs migrate to pathological lesions of neurodegenerative diseases is insufficient, and further efforts are required to elucidate this mechanism.

We recently reported that human MSCs (hMSCs) migrate to CNS lesions and prolong the survival of mice infected with prions (51). In the present study, we investigated factors that are involved in the migration of hMSCs to brain lesions of prion diseases.

Source–> http://jvi.asm.org/content/85/21/11069.full

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Conclusion
–=–

To say that the body is one giant communication system is an understatement. The expression of genes and the ability for host cells to operate normally and to chemically call for help when faced with an antigen is esential to health. As discussed above, these prion interferors with the interferon and other defensive signaling processes must be injected to bypass the mucosus and the skin. This can only be accomplished through innoculation and vaccination.

The introduction of foreign proteins and DNA/RNA into the otherwise healthy body is certainly described here as the cause of most disease states in modern times. And from the time that this interferon was discovered, these psychopathic scientists have been working overtime to prevent our bodies from being able to fight what they inject.

What you have just read is the cause and cure for AIDS, cancers, dementias, and a host of other modern medically-induced disease states that revolve around prion infection and misfolding of the signal processing of the body. It is not so much a cure as an acknowledgement of the cause, for when disease is purposefully caused, the word cure seems trivial in practice, and allows the culprits to literally get away with murder.

It was caused by them…

Will we sit by helplessly and hope for a cure to these purposefully caused diseases by the very perpetrators of them?

Isn’t that the American way though?

For as we wait, they merely perfect their science of biological aggression and warfare…

(Note: all unlinked data as descriptions above from Wikipedia, which are well-sourced within that site.)

.

–Clint Richardson (realitybloger.wordpress.com)
–Thursday, December 4rth, 2014

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