I Am Not The People, And Neither Are You

It is the greatest of fallacies; indeed it might be the greatest public relations stunt ever conceived. It cannot be defined. It cannot be touched or spoken to. It cannot be seen. It has no substance.

And yet we as individuals identify ourselves as it with perfectly unhindered irrationality, while at the same time never being able to grasp its totality of non-existence. It is used to describe every last one of us, even when it singles out one of us to bully and plunder. It represents the basis of the entire structure of power over us, while at the same time somehow being us. And the power of it has created the most impressive false dialectic ever conceived in the history of the world.

Monarchies and dictatorships are surely envious of it, for even the most violent of militarized tyrannies cannot match the shear driving force of the consent of it. And all who oppose it have learned that no power in the world, including an act of God, seems to be able to stop it.

So just what is it?

It is the ambiguous title of “the People.”

In its most surreal application, the People is most often used to cause a lack of tangible responsibility for the actions of the People. Like the Dr. Jeckyl and Mr. Hyde model, the men and women that make up the citizenry of government can simply blame the government for everything done in the People’s name, even though it was supposedly done with the consent of the governed. For the government, the men and women that make up that legislature and Executive branch can simply blame the citizenry for giving their consent as the governed People, never admitting that their own actions (which are often despite the actual People’s will) were anything but the will of the People.

Either way, it seems, no one is ever to blame for the actions of the People because the People simply does not exist.

Does the People cast a shadow? Can the People be touched or seen? Can the People actually only speak with one voice, considering it supposedly equates to all the citizens in the nation? Can the elected officials somehow be the People despite the rest of the People just because those People voted for the legislators to be the voice of the People?

Just who, in the end, do you suppose is taking responsibility as the actual People? Is it the president? Is he the People when He decides to act as the People without actually consulting the People? Is the entire citizenry of People thus responsible as a collective People for the actions of the president acting as the People?

The People vs. The People

I can just imagine it… where all parties claiming to be the People actually go into arbitration so as to decide just who is in actuality responsible for the actions of government. It would be more devious than a divorce case, more televised than the O.J. Simpson case, and more flippant than a cat in a hot tub.

The common People would claim that the government committed a crime. The government would then counter-claim that the People voted for government, and therefore the crime was in the name of the People. But, so argues the attorney for the voting People, government is acting without consulting the People in its actions. To which government’s Attorney General retorts that the People gave consent for the government to act as the People in all things political, which really means that government is the spirit of the People. Nay, nay, says the common People’s representative, for the People have voiced in private and have called and sent petitions to these re-presentations of the People in government and spoken their individual opinions of government’s actions, and a majority of the People do not approve of government’s actions while acting as the People. And still in stalemate defiance, the government would claim that while the People certainly have the right to individually voice their personal opinions under the doctrine of “free speech”, says the Attorney General for the United States (i.e. the People), the People (government) is certainly not required in any way to consider the People’s (any citizen’s) individual opinions on the actions of government (the People)…

And at this point, Judge Judy slams her gavel down in Talmudic entropy and declares a mistrial due to irreconcilable differences in sameness.

And when the opinions of the case are written into case law, it would read that no distinction could be established in either separating the government from the People or the People from government, and that no individual citizen could claim to be the People, for all the People cannot be manifest in just one common person. Finally, it is the courts opinion that no individual or group of persons can claim to be the actual full body of People, because the People is a plural title for a singular body politic called the People. Therefore, only government can call itself the People, despite the fact that government is merely a fiction of law with no substance, and so the People cannot in fact sue the government for the government is in fact and in title actually the People.

Final decision: the case cannot exist because the People cannot sue the People. The government cannot sue itself. The People, therefore, must submit to the will of the People.

Here exists the hand of the People,
claiming to exist despite its non-existence,
presenting its own representation.

Say What?

If the above is confusing for you, ask yourself a few questions….

Are you a People? Is there any way that the word People can be a singular term that refers to only one man or woman?

Is government a People? Inasmuch as Walmart is a corporation, and the entire staff, board, CEO, shareholders, and owners could loosely be called a People, then yes.

Is government the People? How can government be all of us People if we are not voting for the actions or laws created by the small group of People in government?

Sure, we vote for which persons will inhabit government, but those People never ask permission from the rest of the People who voted for them when they pass laws on the People’s behalf. But if the government (the People) is able to put the responsibility of its actions on the entirety of all the People, then is it any wonder that the People never punish the People in government for crimes against the People?

Trying to figure out just what the People is at this point is like looking at an infinite, self-similar fractal. The beginning and the ending of just what the People is can never be truly be ascertained. And just when you think you have it figured out, you realize the paradox that its true quantitative power is that it is an equation with no solution – an impossible perfection of the political corruption of natural reason and logic.


Don’t get lost


How can such a nonsensical word as the People have been foisted upon the masses of men, who self-identify as both an individual sentient being and a fictional plural construct? How can hundreds of millions of men be convinced that they are not men but legally a single hive-minded political term known as the People? And from that experiential belief, how were so many strong-willed men able to be convinced that We, the People is the creator of all things and all laws, and that even though they are supposedly one of the People, the People can somehow single one of the individual People out and sue, fine, tax, punish, imprison, and even put to death that individual all in the name of that great god called We, the People? Amazingly, even as individual sentient beings, we still consider and address ourselves not as our selves, but as the whole People. I am We. We am I.

And therein lies the greatest word magic and trickery ever spell-cast. For by saying I am We, the People, a man is really saying I am of government. I am a fictional representation of myself. I am an individual fictional person and one of the fictional People at the same time? I am not man. I have no voice. I am totally controllable. I am a creation of government

Literally, my will is the People’s will, and so therefore the People’s will tells me my will, whether I like it or not, and whether the People them-selves like it or not. Cause there are no real People, just a bunch of subjects called persons. It’s all just a fiction. Just a name. A big lie.

Maxim’s Of Law:

“The creator controls.”

“A thing similar is not exactly the same.”

“One who wills a thing to be or to be done cannot complain of that thing as an injury.”

“He who consents cannot receive an injury.”

“Consent removes or obviates a mistake.”

“The agreement of the parties overcomes or prevails against the law.”

“Agreement takes the place of the law: the express understanding of parties supercedes such understanding as the law would imply.”

“No one can sue in the name of another.”

“It is immaterial whether a man gives his assent by words or by acts and deeds.”

“A fiction is a rule of law that assumes something which is or may be false as true.”

“Where truth is, fiction of law does not exist.”

“Whoever does anything by the command of a judge (magistrate/We, the People as god) is not reckoned to have done it with an evil intent, because it is necessary to obey.”

“Where a person does an act by command of one exercising judicial (magistrative) authority, the law will not suppose that he acted from any wrongful or improper motive, because it was his bounded duty to obey.”


Why can’t anyone get in trouble by the law for crimes against humanity? Because People aren’t men! A man acting in person as one of the People has the permission of the People to do what the People tell the person to do on behalf of the People. In other words, if the People are sovereign, and a sovereign knows no law above it, then the People have no real law when acting as the sovereign We, the People, and pretend to operate their crimes under the law of the People! This is the simulacra and simulation of the People and of government. The People is a copy with no (living) original. The government is similar to the law but not the law; a simulation of God. This is the fractal reality of a great and powerful lie, the underlying law being truly that of anything goes.

Who, what, where, when, and how is the People?
Will the real People please stand up?


People is a fiction of law. The law, however, assumes that the fiction (People) is non-fiction (Mankind), and that therefore the fiction is true in the eyes of the law. The law says that all of mankind are a single People. Man acting as persons of the People (government) are acting in another name (in the name of the People), and so man acting in the name of or as the People can certainly not sue the government, for the government is the People, and the People cannot sue the People itself, and so this makes somehow a functional paradox we call justice.

The People cannot really complain to government, which claims to be doing the will of the People, because again the People cannot complain about the People. They are the same thing. One single body politic. On individual thing. E pluibus unum. One world order is merely a one world People of the same world government (the People). Individual nations are called “state’s” of the United Nations, and the member nations will just be the new People of the One World Nation. For ultimately, in a global government, the People that is the United States will only be considered one individual person in the United Nations.

Now don’t be confused, for it is easy to fall into the fractal trap of this word porn. A diehard “We, the People” person that just can’t imagine not being regarded as a plural and thus actually be responsible for his own actions despite the People he identifies himself as, and therefore as a real non-dependent man, is no longer able to blame government or his mistaken identity he calls the People for his or her own inaction; somehow blaming all other People as opposed to himself while simultaneously believing that he is indeed one of the People which he himself blames. Damn People!

Whoa there!

Seriously, before the fractal gets way out of hand (Mandelbrot would be so proud), let’s make sure that this whole diatribe isn’t just some modern abstract from a fractal crack-head’s dream…

Let’s see what this word People means in the legal books:

PEOPLE, noun [Latin populus.]1. The body of persons who compose a community, town, city or nation. We say, the people of a town; the people of London or Paris; the English people. In this sense, the word is not used in the plural, but it comprehends all classes of inhabitants, considered as a collective body, or any portion of the inhabitants of a city or country. 2. The vulgar; the mass of illiterate persons. The knowing artist may judge better than the people 3. The commonalty, as distinct from men of rank. Myself shall mount the rostrum in his favor, And strive to gain his pardon from the people 4. Persons of a particular class; a part of a nation or community; as country people 5. Persons in general; any persons indefinitely; like on in French, and man in Saxon. 6. A collection or community of animals. The ants are a people not strong, yet they prepare their meat in the summer. Proverbs 30:25. 7. When people signified a separate nation or tribe, it has the plural number. Thou must prophesy again before many peoples. Revelation 10:11. 8. In Scripture, fathers or kindred. Genesis 25:8. 9. The Gentiles. –To him shall the gathering of the people be. Genesis 49:10. – verb transitive  – To stock with inhabitants. Emigrants from Europe have peopled the United States. (–Webster’s 1828)

PEOPLEA state; as the people of the state of New York. A nation in its collective and political capacityThe aggregate or mass of the individuals who constitute the state… In a more restricted sense, and as generally used in constitutional law, the entire body of those citizens of a state or nation who are invested with political power for political purposes, that is, the qualified voters or electors… In neutrality laws, a government recognized by the United States. The word “people” may have various signification according to the connection in which it is used. When we speak of the rights of the people, or of the government of the people by law, or of the people as a non-political aggregate, we mean all the inhabitants of the state or nation, without distinction an to sex, age, or otherwise. But when reference is made to the people as the repository of sovereignty, or as the source of governmental power, or to popular government, we are in fact speaking of that select and limited class of citizens to whom the constitution accords the elective franchise and the right of participation in the offices of government. (–Black’s 4rth Edition)

PEOPLE – Ordinarily, the entire body of the inhabitants of a State. In a political sense, that portion of the inhabitants who are intrusted with political power; the qualified voters. The words “the people” must be determined by the connection. In some cases they refer to the qualified voters, in others to the state in its sovereign capacity. The United States government proceeds directly, from the people; is “ordained and established” in the name of the people. It is emphatically and truly a government of the people. In form and substance it emanates from them. Its powers are granted by them, and are to be exercised directly on them, and for their benefit.” Under our system, the “people,” who in England are called “subjects,” constitute the sovereign. The simple word “people”  is sometimes applied to a nation or foreign power. When the constitution of a State directs that processes shall run in the name of the State, a process in the name of the “people” will be held deficient, notwithstanding the form be statutory.” See Citizen; Country; Government; Lex, Salus, etc.; Magistrate; Nation; Sovereignty; State, Welfare. (–W.C. Anderson 1889)


Ever wonder why a petition never seems to work? That’s because a petition is not created by all the People, but only by some persons. Persons are not the People. In other words, a petition may be considered as legal evidence, but not as the will of the People. The People is a legal concept that the People can’t seem to access, though We are supposedly the People.

PETITION – A written address, embodying an application or prayer from the person or persons preferring it, to the power, body, or person to whom it is presented, for the exercise of his or their authority in the redress of some wrong, or the grant of some favor, privilege, or license.

PRAYERThe request contained in a bill in equity that the court will grant the process, aid, or relief which the complainant desires. Also, by extension, the term is applied to that part of the bill which contains this request.

PRAYER – chancery pleadings. That part of a bill which asks for relief. 2. The skill of the solicitor is to be exercised in framing this part of the bill. An accurate specification of the matters to be decreed in complicated cases, requires great discernment and experience; it is varied as the case is made out, concluding always with a prayer of general relief, at the discretion of the court.


We pray to the court, because the court is the god, an other word for magistrate, which is another word for government as the People. The court represents We, the People against us, either wholly or as individuals or corporations. We as individuals or groups, associations, or corporations are never addressing the court as the People, it is the Court that is addressing us as the People, because government is the People. It is impossible for the People to sue the court because the court is the People. The court offers the opinion of the People. All we can do is pray to that magi-god in a black robe for remedy. The word prayer has been modernly re-named into “pleading.” The People need not plead, for the court is the People.

The Chicken Or The Egg?

I’m not sure how many other ways I can say this, but it should be clear that I, you, we, and us is not the People. It’s a physical impossibility, which is part of the strategy of control. The government knows that the People can never be together in one room, acting as its true self – all the millions of actual voters. It’s a gloriously impossible feat. And that’s why the legal god that has been named the We, the People as a representation of the People is so powerful and seemingly immutable.

The only last fallacy to be consumed in the fire of this fractal debtor’s hell is to dispel the notion that the People created the government. Here again, the romantic patriotic view is that the People all voted for the constitution. Of course this is a verifiable untruth. Very few of the People could vote, because they weren’t good enough to vote due to blood, status, lack of land-holdings, and of course color. The People who created the constitution were clear on this 3/5ths of a point, which makes it humorous to see a patriotic “negro” man eager to wave the flag.

While it is accurate to say that the group of Free-masonic men who signed the constitution were certainly a specific, proper noun group of People, it is not accurate to say that they were all the People of the entire nation, any more than it is accurate to say that the legislature actually represents the will of every person in the United States as the People. It is more accurate to say that the individual states as body politics’ were the things that made up the People, and not the men within acting as citizens, slaves, and voluntary or involuntary servants. The People, as defined above, are the states of the nation and therefore is the nation itself. That’s not real People, that’s just an incorporated thing. An idol. A god.

How could there have been a People if there was no nation? Was there a specific day that all men became the People? They certainly weren’t natural born at the time they became the People. Could the People of a nation exist before the nation was created? Obviously, if none of us out here can represent the People in court, then we are not really the People.

If government disappeared tomorrow, there would be no place for the People to legally appear as a legal body. For the People only exist as and in a fictional jurisdiction. Government creates and becomes the People, and the creator controls.

And so I end this puzzling commentary with one last question…

When are you going to quit denying the beauty and wonder of your uniqueness and individuality, quit denying your personal responsibility, and quit letting evil men commit atrocious crimes against all the men and creatures of the Earth in your name – in the name of the god of We, the People?


–Clint Richardson (realitybloger.wordpress.com)
–Thursday, January 15th, 2015

The Absurdity Of Modern Free Speech

In light of yet another Talmudic spectacle of intentional despoilment of any respect America might have left in the world, isn’t it time to admit that from within the arsenal of complex patriotic weapons used as universal excuses for downright bad behavior, the free speech card has been well overplayed?

Watching the people of America being strung along like fiddles in quite forced romantic support for an at best mediocre movie before its release through a poorly-staged conspiracy worthy only of the lowest freak show display was painful. Despite the false dialectic of public outcry created by the now infamous ‘corporations are people too’ comment by Mitt Romney last election cycle – ridiculous not in its insanity but in its utterly soul-saturating truth – the collective dichotomy has now been sublimely shifted into supporting a corporation’s free speech in its release of a mainstream movie. For the doctrine of free speech is equally yoked in natural and artificial persons, thanks to the virtually unlimited exceptionalism given to the chartered 1st amendment.

No such demand would have been artificially created, plugged, and asserted through the magic of media trickery if the movie at question would have been a true historical documentary relating to a sympathetic view of Hitler and the easily proved false-history pertaining to the so-called “Holocaust.” In fact, even the very thought of public support for “free speech” as an excuse for the desire of making and releasing such a documentary film without protest or political barrier, provable as every fact would be, is a generally repugnant public opinion. For when push comes to shove, the responsibility that is implied in the creation of and thus use of this notion of free speech is being disappeared and then reappeared in the legal setting whenever it serves the interests of powerful men in their rewriting of current and past history.

Would a “comedy” put forth by the same two Jewish film-maker/actors and by the same Jewish-run media corporations with the plot of assassinating specifically the current President Obama through clandestine, covet means be acceptable free speech as well in this free speech society? By the current standards regarding “The Interview” movie it would. How about a snuff film about stabbing Mother Theresa to a bloody pulp with a crucifix, or better yet a splintery Dreidel? Does the amorphous, ambiguous term “free speech” also somehow protect such efforts in the purview of public opinion?

The question I pose today is a difficult one… Is free speech really to be considered an unrequited absolute?

Bearing in mind that the term “free speech” is not in any way defined in its constitutional proclamation in the articled 1st amendment, does the rational man truly believe that this is the legal version of anything goes? Can there be law without a foundation of some moral compass as a limit to the absoluteness of that law, especially when we consider that we are all forced to accept that even the most immoral speech is publicly acceptable because public opinion says all speech must be free and accepted?

And how soon will the element of freedom turn into the chains of subjection as the gavel of the supreme court resounds the new law that free speech and expression of opinion about certain Zionist factions only equals hate speech, as has happened in so many other “civilized” nations?

From both a logical and Biblical perspective, the answer is touted in support of the duties invoked by natural law (God’s law-order) to do no harm rather than to just accept this supposed unabashed liberty-without-responsibility assumed in the modern interpretations of constitutional theory. Here, Rousas John Rushdoony says it best in his foreshadowing warnings:


“…[A] society which makes freedom its primary goal will lose it, because it has made, not responsibility, but freedom from responsibility, its purpose. When freedom is the basic emphasis, it is not responsible speech which is fostered but irresponsible speech. If freedom of press is absolutized, libel will be defended finally as a privilege of freedom, and if free speech is absolutized, slander finally becomes a right. Religious liberty becomes a triumph of irreligion. Tyranny and anarchy take over. Freedom of speech, press, and religion all give way to controls, totalitarian controls. The goal must be God’s law-order, in which alone is true liberty.”

“Whenever freedom is made into the absolute, the result is not freedom but anarchism. Freedom must be under law, or it is not freedom…. Only a law-order which holds to the primacy of God’s law can bring forth true freedom, freedom for justice, truth, and godly life. Freedom as an absolute is simply an assertion of man’s “right” to be his own god; this means a radical denial of God’s law-order. “Freedom” thus is another name for the claim by man to divinity and autonomy. It means that man becomes his own absolute”

–Rousas John Rushdoony, The Institutes of Biblical Law
(The Presbyterian and Reformed Publishing Company, 1973) p. 581, 583–


As a rational man or woman, can the reader truly accept that this simple term “freedom of speech” was intended to equate to freedom from responsibility, ethics, respect, and from the very notion of the law itself? Can laws against such freedom of speech such as slander and perjury truly be subservient and bypassed by the right to free speech itself?

We have certainly defined the word freedom before on this blog, and so we know that political freedom is under the state of a false legal capacity. No matter which dictionary of law and court opinion we open, we find the same definition of the term.

FREEDOMLiberty; the right to do what is not forbidden by law. Freedom does not preclude the idea of subjection to law; indeed, it presupposes the existence of some legislative provision, the observance of which insures freedom to us, by securing the like observance from others. –Bouvier’s 1856

FREEDOM – The state of being free; liberty; self-determination; absence of restraint; the opposite of slavery. The power of acting, in the character of a moral personality, according to the dictates of the will, without other check, hindrance, or prohibition than such as may be imposed by just and necessary laws and the duties of social life. The prevalence, in the government and constitution of a country, of such a system of laws and institutions as secure civil liberty to the individual citizen. –Black’s Law 1st


The fact is that this notion of “free speech” in the constitution needs to be taken for its intent, not in its stretched out modern usage as an excuse for immorality and irresponsibility.

To be free in speech means to not be forced to say something against your will. This negative right, with regards to the legal setting, is designed to avoid false witness under coercion and to avoid self-incrimination, which means that the law cannot harm a man for speaking his mind or even the truth as a defendant or witness. Here though is assumed a sense of personal control and responsibility with our speech that it should not defame or arbitrarily defraud another, which the laws are clear to punish in perjury. And this free speech doctrine was not intended to apply to all aspects of personal life, only to political ones regarding rights and duties.

Does this specific notion of freedom from being forced to say something against ones will really imply too that a man (as a citizen) must thus allow any degrading, debilitating, slanderous opinion or untruth to be uttered at any time, tossing personal responsibility out the window while hiding under the false notion that all speech is protected by the god of the constitution; the god without substance known as We, The People?

This author believes the answer here to be no, at least with regards to the intent of the notion of what this doctrine of freedom of speech is with intent designed to protect. The concept of law is not designed to be used to force all speech upon others, any more than it is designed to force actions and political participation.

Frederick Nymeyer in Progressive Calvinism stated that:

“What gold is to money, the law of God is to liberty.”

When comparing this notion of personal responsibility with the modern perversion of the seemingly unlimited liberty of modern free speech, one must question just where the foundation of that doctrine may be found? Just as our U.S. dollar, as an unlimited currency, has no foundation in intrinsic physicality or morality (i.e. it is not “backed” by a foundation of gold) and is therefore without actual limit in its liberty of production, the currency of free speech in its projected unlimited capacity seems to be as well without foundation or principle in the modern era – totally misused, abused, and out of control! Both of these things seem to be killing us slowly; the bankrupting not only of our bank accounts but of our prosperity, integrity, and national reputation as well.

The public relations spectacle that was the Sony/Franco/Rogen/North Korea/Obama public opinion dilemma, as poorly played as it was, was quite effectual not only in positively publicizing the immorality and societal subversion of the Zionist Protocols of the Elder’s agenda, but also in the art of the swaying of public opinion without a day in court. It was a hoax of hoaxes; a successful subversion of reality and lawful intent. It was a typical American meme from the meme machine of Hollywood proper.

Should free speech be religiously used to protect all forms of speech?

Should this unlimited doctrine be protected even when the speech itself is offensive to law and freedom itself?

Should free speech be allowed to intrude upon the private rights of others?

And at what point does free speech become indistinguishable with forced speech, where you must hear it pumped into your living room and at work 1984 style and thus pretend to agree with it because the law forces you to accept and live by it as an unlimited right guarded by the thought police?

When is freedom actually redefined as objectified tyranny?

You decide…

And after your own contemplations, ask yourself why you allow others to define what is right and just in your own mind, what is correct and moral by the justice of legal code, and why it is that “entertainment” is now a legitimate title and excuse for pure unadulterated corruption and subversion protected by law?

The answer is simple and clear in all cases. Government is the supreme god (magistrate) from which all public opinion now flows.

MAG’ISTRATE, noun [Latin magistratus, from magister, master; magis, major, and ster, Teutonic steora, a director; steoran, to steer; the principal director.] A public civil officer, invested with the executive government of some branch of it. In this sense, a king is the highest or first magistrate as is the President of the United States. But the word is more particularly applied to subordinate officers, as governors, intendants, prefects, mayors, justices of the peace, and the like. The magistrate must have his reverence; the laws their authority. –Webster’s 1828

GODnoun – 2. A false god; a heathen deity; an idol. 3. A prince; a ruler; a magistrate or judge; an angel… 4. Any person or thing exalted too much in estimation, or deified and honored as the chief good.- verb transitiveTo deify. –Webster’s 1828


Is the law exalted too high? How about the magistrates as the law-givers and administrators? Do you as a subject of the body politic (e pluribus unum) even recognize that you worship the law of the gods as magistrates?

As the saying goes: Change your god, change your law… before God’s law becomes illegal.

P.S… This is what responsible speech looks like!!!


–Clint Richardson (realitybloger.wordpress.com)
–Thursday, January 8th, 2015

The Prion Chronicles: The Story Of Interferon


These are the continuing chronicles of prion disease, the reason for your own state of unease.

For past research and understanding of just what a prion is, see my previous research here:

Link–> https://realitybloger.wordpress.com/2012/11/11/xenotransplantation-creating-the-zombie-appocalypse/

Link–> https://realitybloger.wordpress.com/2013/02/20/the-prion-chronicles-prions-and-als/


I wish to pose a question…

Is it possible that, in our efforts to create synthetic drugs (for profit) in order to artificially mimic or replace the body’s natural health and healing processes, even while suppressing the body’s immune response to those drugs so that they may fool the natural system, we have inadvertently created a permanent state of dis-ease as the average human condition?

Let’s take an obscene example.

Over half a century ago, while researching the efficiency of the vaccine for smallpox, Japanese virologists working for the Institute For Infectious Diseases at University of Tokyo published their findings (1954) that some “viral inhibitory factor” was inhibiting the growth of their purposefully induced viral infection of laboratory research rabbits. In other words, the tiny rabbit bodies were having the natural immune response they should, which interferes with the capability of a foreign zoological pathogen to propagate (grow and reproduce) after injection. But they also discovered through isolation of this unknown and naturally occurring preventative substance that it was not originated from antibodies. The desired immunization process of antibody stimulation through vaccination was being profoundly prevented.

Three years later, at the National Institute for medical Research in London, virologists discovered similar causal effects on the growth if influenza virus in chicken egg membranes. Something was again naturally interfering with the growth of the virus after purposeful (unnatural) injection. In their research paper they coined this viral inhibitory factor as “Interferon“.

At the same time, back at the University of Tokyo, those same Japanese virologists finally discovered the essense of what they originally coined as “Viral Inhibitory Factor (VIF)”,  and both research branches agreed that this anti-viral substance was caused by the same class of factors, and eventually these became officially known in medical science as “Interferon” (multiple types).

Further study revealed that these Interferon proteins reside in different human chromosomes, and a purification process of biologically active beta interferon was finally isolated in 1977. By the early 1980’s interferon protein types were isolated and cloned to show conclusive proof that indeed interferons were responsible for interfering with viral reproduction. Eventually, these interferon isolates were used as a treatment for viral infections.

So what are these naturally interfering produced factors, and why do pharmaceutical corporations hate them so much that they seek to interfere with their pre-programmed interference?

Clinically defined, Interferons (IFNs) are proteins (glycoproteins called cytokines) made and released by healthy host cells (naturally occurring cells in your body) in response to the presence of pathogens such as viruses, bacteria, parasites, or tumor cells. They literally act as communication devices traveling as RNA messengers, allowing cells to communicate with each other like micro text messages, creating a trigger effect to “interfere” with disease and viral replication by turning on the protective defensive structure of the immune system that is responsible for activating immune cells (natural killer cells, macrophages, etc.). Interferons also increase the ability of uninfected host cells in their ability to resist new infection by virus (an invading parasite to the host cell), and communicate the known presence of tumor cells to the immune system, up-regulating antigens to T lymphocytes.

A lymphocyte is one of 3 cells from the vertebrate’s immune system found in the lymphatic system called NK (natural killer) cells, B  cells, or T cells. There are currently identified 10 distinct interferons (IFN’s), 7 of which are found in humans. These are further broken down by classes (types 1, 2, and 3). All of these IFN’s are vital for the body’s defense against disease states and infections as well as prevention of tumor growth.

In layman’s terms, we could say that all of the body’s naturally healthy cells send out cell-phone calls in the form of amino acids (proteins), which float through the body as if upon a wirelessly fluid Ethernet, directly connecting to the body’s receiving phone-line like a 911 emergency call; thus literally summoning the body’s first responders in the form of the immune system to send out little firefighter cells (Natural Killer, B, and T-cell lymphocytes) to stop the spread of the fire caused by viral, bacterial, parasitic, or tumor causing pathogens that are invading the host cells.

Those Pesky Little Interferons

While interferons have been used in some cases as a breakthrough yet totally underutilized treatment for the slowing or halting of certain disease growth in humans, we find a much more sinister reason for such research and identification of interferons in modern medicine and vaccine production. You see, the original discovery of interferons was not an altruistic attempt to isolate and synthesize an amino acid compound that would treat disease. In fact, far from it…

Back in 1956, those Japanese and British virologists were not trying to cure disease. No, they were trying to induce disease within their animal subjects for research purposes and spread it into chicken eggs so as to grow the disease for vaccination and “other” purposes; chicken embryo substrates being the most popular method for disease culture growth. But as they learned through continuous interference from the host subjects, something kept getting in the way of their purposeful disease infection of those hosts – an at the time unknown intracellular function of the body as of yet unknown, later to be named as Interferon.

Please understand… in order to vaccinate against disease, these scientists believed that they had to stop the bodies own natural defense against the very disease these scientists were trying to purposefully infect their test subjects with. Some might call this a paradox… or just insanity. In order for their pseudo-science to supposedly work, those virologists had to figure out a way to cut the cell-phone signaling process (now known as interferon) caused by their purposeful inoculate infection of the hosts. They needed to cause the body to cease in its perfectly natural capacity to fight the very disease they were injecting into it, so as to grow the disease within that host body. This would seem to the average person to be, on the surface and rightly so, a counter-productive effort on their part. But then the average person could never comprehend what was happening behind the scenes, let alone the true purpose of funding such experimental “science” as medicine.

Let’s take the phenomenon known as Auto-Immune Deficiency Syndrome (AIDS) for example…

What are its symptoms?

Rare cancerous tumors, viral-like infection, wasting syndrome, and general immune-supression of the lymphatic system.

Sound familiar? Like maybe the body’s phone-lines are down?

The body works though a system of communication devices in bilogical form. When one part or system of the body needs to communicate with another, it does so through a highly advanced structure of expressive signaling and transduction; the release of various types of cells, proteins, and other substances that trigger each inter-dependent system to respond in kind. It is this body-wide platform of cellular communication that is being attacked and blocked by the introduction of inhibiting factors like infectious prions and other melevolent substances.

The body works just fine until it is stung and thus injected (vaccinated) with foreign proteins, DNA, RNA, and other ingreedients that in no other way would ever be able to insert themselves into the body of man (or rabbit).

The main issue with AIDS patients is the lack of the body’s immune response regarding the production of T Lymphocytes, commonly called T-cells. For some reason, despite the body’s many dis-ease states as symptoms of the AID-syndrome,  the body just isn’t getting the hint to produce the very thing that it needs to fight infection. It seems we have a failure to communicate here… For some reason the emergency 911 cell-phone lines seem to be cut, and the first responders (T-cells) are just not being called into action by the healthy cells that are under attack. Their chemical screams for help are going unheard. It’s as if the immune system labor union went on strike, and these “AIDS” symptoms are the resulting chaos and unrest that ensues throughout the body.

Not ironically, these are the same symptoms of what is known as Gulf War Syndrome, a known vaccine induced disease state thought by many researchers to be caused by vaccine adjuvants like squalene and other ingredients injected into the guinea pig soldiers of our military.

But what could possibly cause such a chain reaction throughout the body’s immune-supressive system?

What could possibly have been introduced within the body to prevent its ability to make a protein phone call, just like in those poor test-rabbits so many decades ago?

What is preventing interferon from interfering with the disease process, defeating its attempts to transmit its signal for help to the imune system?

Enter bioengineering and the novel prion…



So how could this novel disease state be simultaniusly spread
throughout Africa and eventually the first world?


Altering Gene Expression: Just A Little Pinprick


“The genetic code is universal….
The complete word-for-word universality of the genetic dictionary is,
for the taxonomist, too much of a good thing.”

–Evolutionist Richard Dawkins, in his book,
‘The Blind Watchmaker’ (1986, p. 270)


“It is recognized by molecular biologists that the genetic code is universal,
irrespective of how different living things are in their external appearances.”

–Creationist Robert Kautz, in his book,
‘The Origin of Living Things’ (1988, p. 44)


“The construction and metabolism of a cell are thus dependent
upon its internal ‘handwriting’ in the genetic code.
Everything, even life itself, is regulated from a biological viewpoint
by the information contained in this genetic code.
All syntheses are directed by this information.”

–A.E. Wilder-Smith, United Nations scientist (1976, p. 254).


“It may seem a platitude to say that the offspring of buttercups, sparrows and human beings are buttercups, sparrows and human beings… What then keeps them, and indeed living things in general, “on the right lines?” Why are there not pairs of sparrows, for instance, that beget robins, or some other species of bird: why indeed birds at all? Something must be handed on from parent to offspring which ensures conformity, not complete but in a high degree, and prevents such extreme departures. What is it, how does it work, what rules does it obey and why does it apparently allow only limited variation? Genetics is the science that endeavours to answer these questions, and much else besides. It is the study of organic inheritance and variation, if we must use more formal language.”

–British geneticist, E.B. Ford,
‘Understanding Genetics’ (1979, p. 13).


“Tablets of stone prepared by the Babylonians some 6,000 years ago have been interpreted as showing pedigrees of several successive generations of horses, thus suggesting a conscious effort toward improvement. Other stone carvings of the same period illustrate artificial cross-pollination of the date palm as practiced by the early Babylonians. The early Chinese, many years before the Christian era, improved varieties of rice. Maize was cultivated and improved in the western hemisphere by the American Indians, beginning at an early period in their history. In another era, Hippocrates, Aristotle, and other Greek philosophers made observations and speculations suggesting genetic principles.”

–Eldon Gardner, ‘The History of Biology’ (1972, pp. 399-400)


“And God said, let the earth put forth grass, the herb
yielding seed,  and the fruit tree yielding fruit after its kind,
wherein is the seed thereof upon the earth, and it was so.
And the earth brought forth grass, the herb yielding seed and
the fruit tree yielding fruit after its kind whose seed was in itself.”

–The Bible, Genesis 1:11-12


“In the first chapter of Genesis, however, because it is a matter of the greatest religious importance, the Bible speaks clearly and finally on a matter of biology. After its kind is the statement of a biological principle that no human observation has ever known to fail. The most ancient human records engraved on stone or painted on the walls of caves bear witness to the fact that horses have ever been horses, bears have ever been bears, geese have ever been geese, reindeer have ever been reindeer. The most desperate and subtle efforts of man in modern times have been unable to alter this divine decree. The Bible teaches that from the beginning there have been a large number of types of living things, man included, which were so created as to remain true to their particular type throughout all generations…. The latest results of modern biological research, Mendel’s Laws, agree exactly with what was written by Moses three thousand years ago—and they also elucidate it…”

Byron Nelson, ‘After Its Kind’, (1967, pp. 3,103)


“…once a fertilized, (a) single human cell begins to develop, the original plans are
faithfully copied each time the cell divides (a process called mitosis)
so that every one of the thousand million million cells in my body, and in yours,
contains a perfect replica of the original plans for the whole body”.

–Evolutionist John Gribbin (1981, p. 193)


“The Nobel laureate, F.H. Crick has said that if one were to
translate the coded information on one human cell into book form,
one would require one thousand volumes each of five hundred pages to do so.
And yet the mechanism of a cell can copy faithfully at cell division
all this information of one thousand volumes each of
five hundred pages in just twenty minutes.”

–Dr. Wilder-Smith (1976, p. 258).


“Every organism has in it a store of what is called genetic information… I will refer to an organism’s genetic information store as its Library…. Where is the Library in such a multicellular organism? The answer is everywhere. With a few exceptions every cell in a multicellular organism has a complete set of all the books in the Library. As such an organism grows its cells multiply and in the process the complete central Library gets copied again and again…. The human Library has 46 of these cord-like books in it. They are called chromosomes. They are not all of the same size, but an average one has the equivalent of about 20,000 pages…. Man’s Library, for example, consists of a set of construction and service manuals that run to the equivalent of about a million book-pages together.”

“It is an indication of the sheer complexity of E. coli
that its Library runs to a thousand page-equivalent”

–A.G. Cairns-Smith  (1985, pp. 9,10,11)


“The DNA in living cells contains coded information. It is not surprising that so many of the terms used in describing DNA and its functions are language terms. We speak of the genetic code. DNA is transcribed into RNA. RNA is translated into protein. Protein, in a sense, is coded in a foreign language from DNA. RNA could be said to be a dialect of DNA. Such designations are not simply convenient or just anthropomorphisms. They accurately describe the situation.”

–Lester and Bohlin (1984, pp. 85-86)


Further, consider that human beings have learned to store information on
clay tablets, stone, papyrus, paper, film, cassettes, microchips, etc.
Yet ‘human technology has not yet advanced to the point of
storing information chemically as it is in the DNA molecule



“It is not possible for a code, of any kind, to arise by chance or accident.
The laws of chance or probability have been worked out by mathematics…
A code is the work of an intelligent mind. Even the cleverest dog or chimpanzee
could not  work out a code of any kind. It is obvious then that chance cannot do it…
This could no more have been the work of chance or accident than could the
“Moonlight Sonata” be played by mice running up and down the keyboard of my piano!
Codes do not arise from chaos”

–Professor Andrews (1978, pp. 28,29).

Infecting The World
Through Vaccination


So what happens when man comes clumsily and irresponsibly into the age of molecular science, where he begins to intermix species through inoculation? How can man know if his limits truly are what is written in the ancient scriptures and philosophies of moral men unless he seeks the answers by destroying the perfection of nature’s mathematical equations of the biology of life? How can we know the limits of genetically altered life if we don’t push those limits to the very brink of extinction of species, including our own?

Ancient warnings are for pussies!!!

In my previous research, I have postulated the horrifyingly evidence-based theory that all modern disease states, from the dementia’s to cancer to AIDS, have been induced through the vaccination process via the direct bodily injection of foreign “infectious” proteins called prions. Further research has all but confirmed the reality of this notion, showing that the inherent protective foundation of these cellular proteins in cell health (before infection) are essential to life itself.


Prion protein aids bone marrow

New study findings point to possible stem cell role for normal form of protein

By Charles Choi | January 31, 2006

The normal form of prion protein (PrP) appears necessary for bone marrow stem cells to renew themselves, scientists reported online this week in the Proceedings of the National Academy of Sciences. These findings suggest a potential physiological function in stem cells for the normal form of the widely expressed protein. “Prior to this work there was no hint that PrP had a function in stem cell biology,” co-author Andrew Steele at the Whitehead Institute for Biomedical Research in Cambridge, Mass., told The Scientist. “We are now looking into PrP function in other adult stem cells, particularly neural stem cells.” Prions are infamous for being associated with transmissible spongiform encephalopathies (TSEs) such as mad cow disease, but the function of PrP — the normal, widespread and highly conserved form of prions — remains a mystery. In preliminary studies, co-author Cheng Cheng Zhang discovered 40% of adult mouse bone marrow cells expressed PrP on their surfaces. More than 80% of these PrP-marked cells were red blood cells or their developmental precursors, suggesting PrP might be a marker for long-term hematopoietic stem cells, which can give rise to the entire adult blood system. To determine if PrP was a marker for long-term hematopoietic stem cells, the researchers took bone marrow cells from wild-type mice and purified them into fractions, some of which expressed PrP. Six months after transplantation into lethally irradiated mice, the researchers saw both short- and long-term engraftment in mice that received PrP-containing cells, but only short-term engraftment activity in mice receiving non-PrP cells. While PrP is a marker for long-term hematopoietic stem cells in wild-type mice, PrP-knockout mice still possess these cells, as well as relatively normal levels of their derived progeny. To determine what function PrP might normally have in hematopoietic stem cells, the researchers carried out several rounds of bone marrow implantations. First they transplanted bone marrow from either wild-type mice or a PrP-null strain into lethally irradiated mice. When the engrafted marrow flourished and generated peripheral blood cells, the researchers implanted the newly reconstituted bone marrow into another lethally irradiated mouse group, then repeated the process a third time. In each round after the first, bone marrow originating from PrP-null mice experienced a dramatically reduced ability to renew itself, while cells from the wild-type mice did not. Retroviral infections that expressed PrP in recipients of PrP-null bone marrow rescued this defective process, suggesting PrP is necessary for hematopoietic stem cell self-renewal. Odile Kellerman at the Pasteur Institute in Paris, who did not participate in this study, noted prions often trigger neuron death in TSEs after long incubation periods,” similarly, PrP only impacted hematopoietic stem cells over the long term. “In both cases, PrP appears to contribute to the long-lasting adaptation of cells to injury,” she told The Scientist. Kellerman suggested that when PrP function is disrupted, cells try to adapt, “but in the long term, this turns out to be detrimental.” The exact mechanism behind how PrP might contribute to hematopoietic stem cell renewal remains unknown. Co-author Harvey Lodish speculated PrP might bond to and concentrate a hormone on the cell surface, or help stem cells adhere to neighboring cells or extracellular matrix. “It should prove fairly straightforward to see if it is adhering to other proteins or any known or unknown hormones,” he told The Scientist. William Stanford at the University of Toronto, who did not participate in this study, noted that PrP is tethered to cell membranes via a glycosylphosphatidylinositol (GPI) anchor, similar to hematopoietic stem cell marker Sca-1. “This suggests these GPI-anchored proteins, which have similar functions, may operate through a common mechanism,” Stanford told The Scientist. Future experiments could investigate whether overexpressing PrP in hematopoietic stem cells increases self-renewal, and rescues self-renewal defects such as in the Sca-1 deficient mouse, Stanford added — or if genetically substituting PrP with a different GPI-anchored protein rescues the self-renewal defect seen in PrP-null mice. cqchoi@nasw.org Links within this article C.C. Zhang et al. “Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal.” PNAS Early Edition.
Published online January 30, 2006. http://www.pnas.org B.A. Maher.
“Prion hypothesis proven?” The Scientist, April 21, 2005. http://www.the-scientist.com/article/display/22653/
M. Fogarty. “Prions – The terminators.” The Scientist, July 28, 2003. http://www.the-scientist.com/article/display/13974/
M. Fogarty. “Researchers further define sources of adult blood stem cells.” The Scientist, September 16, 2002. http://www.the-scientist.com/article/display/13257/
J.U. Adams. “The tiniest of life’s rafts.” The Scientist, October 11, 2004 http://www.the-scientist.com/article/display/14978/


Neurons and Astrocytes Respond to Prion Infection by Inducing Microglia Recruitment


The accumulation and activation of microglial cells at sites of amyloid prion deposits or plaques have been documented extensively. Here, we investigate the in vivo recruitment of microglial cells soon after intraocular injection of scrapie-infected cell homogenate (hgtsc+) using immunohistochemistry on retinal sections. A population of CD11b/CD45-positive microglia was specifically detected within the ganglion and internal plexiform retinal cell layers by 2 d after intravitreal injection of hgtsc+. Whereas no chemotactism properties were ascribed to hgtsc+ alone, a massive migration of microglial cells was observed by incubating primary cultured neurons and astrocytes with hgtsc+ in a time- and concentration-dependent manner. hgtsc+ triggered the recruitment of microglial cells by interacting with both neurons and astrocytes by upregulation of the expression levels of a broad spectrum of neuronal and glial chemokines. We show that, in vitro and in vivo, the microglia migration is at least partly under the control of chemokine receptor-5 (CCR-5) activation, because highly specific CCR-5 antagonist TAK-779 significantly reduced the migration rate of microglia. Activated microglia recruited in the vicinity of prion may, in turn, cause neuronal cell damage by inducing apoptosis. These findings provide insight into the understanding of the cell-cell communication that takes place during the development of prion diseases.

Source–> http://www.jneurosci.org/content/24/3/620.full


Prion hypothesis proven?

In vitro infectivity study in Cell stirs tempest in a test tube

By Brendan Maher (bmaher@the-scientist.com) | April 21, 2005

Protein aggregates generated in a test tube infected wildtype hamsters with a disease much like scrapie, according to an article appearing this week in Cell. Such a demonstration has, in the past, been called the gold standard of proof for the prion hypothesis, Stanley Prusiner’s Nobel-winning assertion that infectious, self-replicating protein isoforms are the culprit in transmissible spongiform encephalopathies (TSEs) like scrapie, Creutzfeldt-Jakob disease, and mad cow disease.

Study coauthor Claudio Soto, said that this demonstration, together with a paper published by Prusiner’s group last summer, should allay most doubts. “There is really little room for skepticism,” he told The Scientist.

But the study has done little to quiet prion hypothesis skeptics. “I’m not going to abandon alternative hypotheses for the time being,” said Robert A. Somerville of the Institute for Animal Health, Edinburgh.

While Prusiner’s group had successfully infected a mouse with a recombinant protein derived from bacteria, some argued that their use of transgenic mice susceptible to the disease undercut the power of the demonstration. In the new study, researchers at the University of Texas Medical Branch, Galveston, Universidad Autonoma, Madrid, and the University of Chile in Santiago fine-tuned a cyclical process for amplifying aggregated protein from an infected hamster brain. Through serial dilutions, they were able to infect a wildtype hamster with in vitro–produced aggregates without any traces of the original infectious brain. But skeptics, including a member of Prusiner’s group, argue that using material from a diseased hamster brain could have resulted in residual contamination.

Soto’s group has been using a process that they call protein misfolding cyclic amplification (PMCA), which aids the aggregation of the normal cellular protein PrPc into the misfolded, polymer-forming PrPres that is associated with TSE pathology. The process works in a fashion similar to polymerase chain reaction (PCR) amplification of oligonucleotides. After seeding PrPc with PrPres, the solution is incubated and sonicated. “Once the aggregates become long enough, we split them into smaller pieces so that in a new conversion, a new incubation, they are able to convert more and more of the normal protein,” Soto explained.

Crucially, however, the PrPres “seed” comes from infected hamster brain homogenate, while the normal PrPc comes from healthy hamster brain homogenate. “They actually started from infectious material, and we didn’t,” said Giuseppe Legname, of the University of California, San Francisco, and co-author on the Prusiner paper. “It’s an alternative approach to demonstrate that you might make prions, but to say that these are synthetic prions, it’s very difficult.”

Soto insisted that serial dilutions between rounds of PMCA reduce scrapie brain homogenate to an amount equivalent to a 10 to the minus 10th and a 10 to the minus 20th–fold dilution. Infectivity generally drops off after 10 to the minus 9th, according to the paper. “We’ve completely ruled out the possibility that the infectivity is still remaining from… the original brain,” Soto said...

Source–> http://www.the-scientist.com/?articles.view/articleNo/23325/title/Prion-hypothesis-proven-/


While the article continues to criticize the control group results, which you may read at the link above, the important point here is that scientists are creating prions and making them purposefully more infectious. They are testing them in various substances and frequencies. And through the ultra-sound sonic vibration described above as protein misfolding cyclic amplification (PMCA), they are able to excite the growth factor of infectious prions so that they take over (mis-fold) healthy brain tissue much quicker. This PMCA process is used in autopsy to detect prion disease.

I have my own concerns that these ultra-sound frequencies are the same as used in cell-phone towers and in the process of ultra sound for unborn infants and other medical procedures, as well as other frequencies unknown via smart meters, radio waves, etc. We are playing with the fuel for the fire and there is virtually no escaping this permanent state of sonic bombardment…

It is also interesting to note that two men wsere cured of AIDS symptoms by receiving a bone marrow transfusion not so long ago…

(CBS News) Two men who’ve had HIV for years may now be free of the disease following bone marrow transplants, researchers at Brigham and Women’s Hospital in Boston announced Thursday.

The new research has some attendees at the XIX International AIDS Conference in Washington, D.C. hopeful for a cure.

Timothy Ray Brown, man thought to be first “cured” of AIDS, says he’s still cured
Man “cured” of AIDS: Timothy Ray Brown

Both patients were being treated for cases of cancer. One of the patients underwent a bone marrow transplant two years ago at the Dana-Farber/Brigham and Women’s Cancer Center in Boston, the other had the procedure done four years ago at the same hospital. NBCNews.com reports that one of the patients is in his 50s and has been infected since the early 1980s towards the beginning of the AIDS epidemic and the other man, in his 20s, was infected at birth.

Both stayed on their antiretroviral medication regimens, the standard treatment of HIV, following the transplants.

The researchers discovered that overtime as the patients’ cells were replaced by cells from the donor, evidence of HIV in the patients’ blood tests disappeared. The researchers also said both patients have no signs of HIV in their DNA or RNA and levels of their disease-fighting antibodies have also decreased. The researchers think the medications helped allow these cells to be replaced.

“This gives us some important information,” one of the researchers Dr. Daniel Kuritzkes, an infectious disease specialist at the hospital and Harvard Medical school said in a press release. “It suggests that under the cover of antiretroviral therapy, the cells that repopulated the patient’s immune system appear to be protected from becoming re-infected with HIV.”

The researchers themselves won’t call it a cure yet, saying they still need to check more tissues for traces of the disease. But they were surprised to see no signs of HIV beyond what’s seen in a blood test.

We expected HIV to vanish from the patients’ plasma, but it is surprising that we can’t find any traces of HIV in their cells,” said co-resarcher Dr. Timothy Henrich, also of BWH and Harvard. “The next step is to determine if there are any traces of HIV in their tissue.”

The researchers’ announcement comes days after Timothy Ray Brown, the man known as the “Berlin Patient,” held a press conference in Washington, D.C.,  to say he’s still cured of AIDS five years after undergoing a bone marrow blood transplant

Source–> http://www.cbsnews.com/news/bone-marrow-transplant-eliminates-hiv-traces-from-two-patients-dna-call-it-a-cure/


It is important to note that the chemokine receptor-5 (CCR-5) antagonist prevents the cellular binding of the HIV-1 virus, as is explained in this video:


And how do these prions effect disease states?

Let’s take for example Multiple Sclerosis:

“The etiology of Multiple Sclerosis (MS) is unknown. Existing epidemiologic data suggests that MS can be an infectious disease. MS used to be classified as one of the ‘slow infections‘–many of these are caused by prions. Prions are small, proteinaceous, infectious particles–distinguished from viruses by the absence of intrinsic nucleic acids. In a contrast to the ‘classic’ prional diseases (Kuru, Scrapie or Creutzfeldt-Jacob Disease) that in CNS affect primarily neurons, the ‘target’ cell in MS is an oligodendrocyte. This may explain differences in disease presentation. This paper presents a pathophysiological model of MS based on the assumption that MS is a prional disease. Processes leading to the demyelination in Multiple Sclerosis seem also to involve lymphocytes, astrocytes and macrophages as well as the interferon system…”

Source: http://www.ncbi.nlm.nih.gov/pubmed/8455467


NOTE: The protein that prions are made of (PrP) is found throughout the body, even in healthy people and animals, and necessarily protects cells from infections. However, PrP found in infectious material has a different structure and is resistant to proteases, the enzymes (proteins) in the body that can normally break down other proteins. The normal form of the protein is called PrPC, while the infectious form is called PrPSc — the C refers to healthy ‘cellular‘ PrP, while the Sc refers to infectious ‘scrapie‘, the prototypic prion disease, occurring in sheep. The infectious isoform of PrP, known as PrPSc, is able to convert normal PrPC proteins in humans into this infectious isoform by changing their conformation, or shape. This, in turn, alters the way the proteins interconnect, creating symptoms like transmissible spongiform encephalopathy (holes in the human brain like mad cow disease). PrPSc always causes prion disease. In the end, no cellphone call can be made if the interferon protein is infected and mis-folded before it is able to reach its receiving protien that would activate T-Cells or other immune responses. Another word for mis-fold might be easier to understand as to misinform. The immune system is being lied to in a strange, chemically unbalanced way due to prion protein infections (mis-folding). Sheep blood (serum) is a popular vaccine substrate to grow vaccines for humans upon, and the protein and DNA cannot be filtered out of the final vaccine product. There are no other viable explanations why infectious prions from animals would intermingle within a human body (xenotransplantaion/xenografting).

A thorough and sourced description about prions can be found here: http://www.omim.org/entry/176640

This interference that infectious prions cause to interferon and other protein-based signaling and transcription cells is shown in the research studies below. For those with the gumption, let’s play a biological game of connect the dots.



Prion infection is accelerated in (interferon type 3) IRF3-deficient mice…

The IRF3-dependent pathway is protective against prion infection in cell culture.

We tested whether over-expression of IRF3 (interferon) could affect the production of PrPSc (infectious/mis-folded prions) in the cell culture models. The level of PrPC (healthy prions) was not affected by the transient expression of the genes in uninfected N2a58 cells (data not shown). PrPSc was significantly decreased by overexpression of IRF3 in the 22L-N2a58 cells (Fig. 5A). We confirmed that the activated form of IRF3 (phosphorylated at Ser396 of IRF3) increases in a dose-dependent manner after transfection of the IRF3 gene in both 22L-N2a58 cells (Fig. 5A) and uninfected N2a58 cells (data not shown), indicating that the upregulation of IRF3 phosphorylation seen in the Fig. 5A is most likely due to an increase in the level of IRF3 protein after transfection.

To investigate the effect of downregulation of IRF3 in the 22L-N2a58 cells, we performed knockdown experiments using small interfering RNAs (siRNAs). IRF3 expression was significantly decreased by two types of siRNAs against IRF3, whereas β-actin expression, as the internal standard, was not changed (Fig. 5B)… These data suggest that IRF3 has an inhibitory effect on the production of PrPSc in the 22L-N2a58 cells.

To further evaluate the protective effect of IRF3… After incubation with 22L-infected BH (22L-BH), the cell clones were subcultured for five passages and analyzed by Western blotting with anti-PrP antibodies. The values of the PrPSc/PrPC ratio were inversely correlated with the values of the IRF3/beta-actin ratio (Fig. 5C), indicating that enhanced expression of IRF3 effectively blocks new prion infection.


In the present study, we found that a genetic deficiency of IRF3 accelerates the progression of TSE (transmissable prion disease) following i.p. transmission in mice and that the accumulation rate of PrPSc in the spleen is increased in the IRF3−/− mice. Furthermore, we demonstrated that IRF3 has an inhibitory effect on PrPSc accumulation and that the levels of IRF3 are inversely correlated with resistance to prion infection in cell culture.

IRF3 is known to be constitutively expressed in many tissues and cells (6, 22, 45). Indeed, we confirmed the expression of IRF3 in brains (data not shown) and N2a58 cells (Fig. 5). Furthermore, not only glial cells but also neurons express most innate immunity-related genes and produce type I IFN in response to virus infection (11). Although the role of IRF3 in prion propagation into the CNS is still unclear, we speculate that an absence of IRF3 signaling leads to increased prion replication not only in peripheral tissues but also in the CNS. It would be of great value to examine this further using neuron-specific IRF3-disrupted mice or neuron-specific IRF3-expressing mice.

It was reported in prion infection that genetic disturbance of TLR4 (36) or interleukin-10 (IL-10) (41) leads to shorter incubation periods of prion infection. Since these, respectively, are an upstream and a downstream factor of the IRF3-mediated pathway, the findings may be due in part to functional changes in IRF3-mediated signaling.

Based on these results, two hypothetical models are proposed to explain the inhibitory effect of IRF3 on the prion infection. The first is that MyD88-independent pattern recognition receptors (PRRs), such as TLR3, TLR4, or RIG-I/MDA5, might recognize prion, and the resulting activation of IRF3 could induce various IRF3-responsive genes that may participate in the protective effect. The fact that the in vivo administration of IFNs (interferons), a representative of the IRF3-responsive genes, previously failed to show inhibitory effects on TSE (13, 16) suggests that IRF3-responsive genes other than IFNs may be important for the inhibitory effect of IRF3 on prion infection. Of note, the protective effect of IRF3 against several viruses has been suggested to be largely independent of the production of type I IFN and is probably responsible for the antiviral actions of specific IRF3-responsive genes (10, 18, 21). Peritoneal macrophages from wild-type mice moderately induced tumor necrosis factor alpha (TNF-α) or IL-6 following exposure to PrPSc-mimicking PrP peptides (PrP residues 106 to 126 or PrP residues 118 to 135), whereas TLR4 signaling-mutant mice were impaired in their ability to produce these cytokines (36), supporting in part the hypothesis that some PRRs may sense PrPSc as a sort of PAMP. On the other hand, it should be noted that the MyD88-independent pathway activates both NF-κB and IRF3. Although the induction of proinflammatory cytokines essentially depends upon NF-κB, it was unclear whether the activation of IRF3 was induced by these PrP peptides. In fact, the hallmarks of IRF3 activation, such as phosphorylation, dimerization, and cytoplasm-to-nucleus translocation of IRF3 in 22L-N2a58 cells, were not detected (data not shown). Moreover, it was previously reported that IFNs were not detected in the serum, spleens, or brains of mice infected with scrapie (44). In addition, IFN-β mRNA does not increase in the brains of CJD (human prion disease) patients (7) or mice infected with ME7 prion strain (14). Hence, these results argue against the notion that the IRF3-mediated signaling is activated by prion infection, but it remains to be determined whether transient and weak responses are evoked at an early phase in the infection. The question as to whether IRF3-mediated signaling directly suppresses the production of PrPSc or increases its degradation also remains open.

Another explanation is that prion infection itself may have little effect on the pathway but that the basal activity of IRF3 may have some degree of inhibitory effect on prion propagation. It has been reported that IRF3 can be activated not only by viruses but also by multiple activators such as cellular stress and DNA damage (24, 34). Accordingly, it is possible that constitutive activation of IRF3, albeit at a low level, occurs in the brain even in the absence of a pathogen. This notion is further supported by the fact that constitutive, weak IFN signaling in the absence of viral infection plays a role in modifying cellular responsiveness in the immune and other biological systems (38, 40). Accumulating evidence indicates that many viruses have evolved to evade the innate immune system, including IRF3-mediated signaling (15, 23). For instance, an active mutant of IRF3 has been reported to exert a markedly suppressive effect on cellular HIV-1 infection, and administration of poly(I·C) potently inhibits HIV-1 replication in microglia through a pathway requiring IRF3. Nonetheless, HIV-1 itself does not activate IRF3 but, rather, decreases IRF3 protein in HIV-1-infected cells (12, 37). Likewise, prion infection might disturb the activation of IRF3 even though prion is considered to be largely composed of PrPSc. We are currently investigating this possibility. Furthermore, an analogy can be made between the role of IRF3 in prion infection and that of IL-10. The levels of IL-10 are not increased in the brains of scrapie-infected mice (14, 42), whereas IL-10 knockout mice are highly susceptible to the development of scrapie (41).

In conclusion, we have shown that IRF3, a key transcription factor of the MyD88-independent pathways, operates in the host defense machinery against prion infection. The findings provide new insight into understanding of the innate immunity to prion infection.

Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347345/


Interleukin-10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, IL-10 is encoded by the IL10 gene.[1]

Gene and protein structure

The IL-10 protein is a homodimer; each of its subunits is 178-amino-acid long.[2]

IL-10 is classified as a class-2 cytokine, a set of cytokines including IL-19, IL-20, IL-22, IL-24 (Mda-7), and IL-26, interferons (IFN-alpha, -beta, -epsilon, -kappa, -omega, -delta, -tau, and -gamma) and interferon-like molecules (limitin, IL-28A, IL-28B, and IL-29).[3]

Expression and synthesis

In humans, IL-10 is encoded by the IL10 gene, which is located on chromosome 1 and comprises 5 exons,[1] and is primarily produced by monocytes and, to a lesser extent, lymphocytes, namely type 2 T helper cells (TH2), mastocytes, CD4+CD25+Foxp3+ regulatory T cells, and in a certain subset of activated T cells and B cells.

In biochemistry, a dimer is a macromolecular complex formed by two, usually non-covalently bound, macromolocules like proteins or nucleic acids. It is a quaternary structure of a protein.

A homo-dimer would be formed by two identical molocules (a process called homodimerization). A hetero-dimer would be formed by two different macromolecules (called heterodimerization).

Most dimers in biochemistry are not connected by covalent bonds. An example of a non-covalent heterodimer would be the enzyme reverse transcriptase, which is composed of two different amino acid chains.[1] An exception is dimers that are linked by disulfide bridges such as the homodimeric protein NEMO.[2]

Some proteins contain specialized domains to ensure dimerization (dimerization domains).

Examples of Homodimer include anti-bodies and Factor VII.

Microglia are a type of glial cell that are the resident macrophages of the brain and spinal chord, and thus act as the first and main form of active immune defense in the central nervous system (CNS).

Microglia constitute 10-15% of the total glial cell population within the brain.[1] Microglia (and astrocytes) are distributed in large non-overlapping regions throughout the brain and spinal cord.[2][3] Microglia are constantly scavenging the CNS for plaques, damaged neurons and infectious agents.[4] The brain and spinal cord are considered “immune privileged” organs in that they are separated from the rest of the body by a series of endothelial cells known as the blood-brain barrier, which prevents most infections from reaching the vulnerable nervous tissue. In the case where infectious agents are directly introduced to the brain or cross the blood–brain barrier, microglial cells must react quickly to decrease inflammation and destroy the infectious agents before they damage the sensitive neural tissue. Due to the unavailability of antibodies from the rest of the body (few antibodies are small enough to cross the blood brain barrier), microglia must be able to recognize foreign bodies, swallow them, and act as antigen-presenting cells activating T-cells. Since this process must be done quickly to prevent potentially fatal damage, microglia are extremely sensitive to even small pathological changes in the CNS.[5] They achieve this sensitivity in part by having unique potassium channels that respond to even small changes in extracellular potassium.

Microglial cells differentiate in the bone marrow from hematopoietic stem cells, the progenitors of all blood cells. During hematopoiesis, some of these stem cells differentiate into monocytes and travel from the bone marrow to the brain, where they settle and further differentiate into microglia.[6]

Monocytes can also differentiate into myeloid dendritic cells and macrophages in the peripheral systems. Like macrophages in the rest of the body, microglia use phagocytic and cytotoxic mechanisms to destroy foreign materials. Microglia and macrophagesboth contribute to the immune response by acting as antigen presenting cells, as well as promoting inflammation and homeostatic mechanisms within the body by secreting cytokines and other signaling molecules.

In their downregulated form, microglia lack the MHC class I/MHC class II proteins, IFN-γ cytokines, CD45 antigens, and many other surface receptors required to act in the antigen-presenting, phagocytic, and cytotoxic roles that hallmark normal macrophages. Microglia also differ from macrophages in that they are much more tightly regulated spatially and temporally in order to maintain a precise immune response.[7]

Another difference between microglia and other cells that differentiate from myeloid progenitor cells is the turnover rate. Macrophages and dendritic cells are constantly being used up and replaced by myeloid progenitor cells which differentiate into the needed type. Due to the blood brain barrier, it would be fairly difficult for the body to constantly replace microglia. Therefore, instead of constantly being replaced with myeloid progenitor cells, the microglia maintain their status quo while in their quiescent state, and then, when they are activated, they rapidly proliferate in order to keep their numbers up. Bone chimera studies have shown, however, that in cases of extreme infection the blood-brain barrier will weaken, and microglia will be replaced with haematogenous, cart-marrow derived cells, namely myeloid progenitor cells and macrophages. Once the infection has decreased the disconnect between peripheral and central systems is reestablished and only microglia are present for the recovery and regrowth period.


Transport of prion protein across the blood–brain barrier


The cellular form of the prion protein (PrPc) is necessary for the development of prion diseases and is a highly conserved protein that may play a role in neuroprotection. PrPc is found in both blood and cerebrospinal fluid and is likely produced by both peripheral tissues and the central nervous system (CNS). Exchange of PrPc between the brain and peripheral tissues could have important pathophysiologic and therapeutic implications, but it is unknown whether PrPc can cross the blood–brain barrier (BBB). Here, we found that radioactively labeled PrPc crossed the BBB in both the brain-to-blood and blood-to-brain directions. PrPc was enzymatically stable in blood and in brain, was cleared by liver and kidney, and was sequestered by spleen and the cervical lymph nodes. Circulating PrPc entered all regions of the CNS, but uptake by the lumbar and cervical spinal cord, hypothalamus, thalamus, and striatum was particularly high. These results show that PrPc has bidirectional, saturable transport across the BBB and selectively targets some CNS regions. Such transport may play a role in PrPc function and prion replication.


Cellular prion protein (PrPc) is perhaps best known as a source for the misfolded protein PrPsc (Prusiner, 1997) and as a prerequisite for the development of prion diseases (Mallucci et al., 2000). However, PrPc itself likely has important biological functions. It is found circulating in blood (Volkel et al., 2001) and is found in even higher levels in the cerebrospinal fluid (CSF) (Picard-Hagen et al., 2006). After ischemic events, PrPc levels increase in blood (Mitsios et al., 2007) and in neurons and brain endothelial cells in the peri-infarct region (Mitsios et al., 2007; Weise et al., 2004). These increases may reflect cytoprotective and neuroprotective roles for PrPc as recently reviewed (Roucou & LeBlanc, 2005). PrPc null mice have larger infarct volumes after ischemic events (Weise et al., 2006; Nasu-Nishimura et al., 2008) and more neuronal apoptosis after viral infections (Nasu-Nishimura et al., 2008) than wild type mice. In comparison, mice that overexpress PrPc have smaller infarcts and better neurological outcomes than wild type mice after ischemic events (Shyu et al., 2005). These protective events are likely mediated by PrPc through activation of anti-apoptotic (Spudich et al., 2005) and anti-oxidant pathways (White et al., 1999).

Sources of circulating PrPc likely include platelets (Robertson et al., 2006), endothelial cells (Simak et al., 2002), and lymphocytes (Politopoulou et al., 2000). Among lymphocytes, CD3 and CD8 lymphocytes have especially high levels which increase with aging (Politopoulou et al., 2000). All these cells have membrane bound PrPc that apparently can be released into the circulation. Platelet activation (Robertson et al., 2006) or endothelial apoptosis (Simak et al., 2002), for example, results in release of PrPc from those cells.

Thus, PrPc occurs in both blood and in CSF with levels that are likely responsive to disease states. This raises the question of whether PrPc can cross the blood–brain barrier (BBB). Such passage could link the two pools of PrPc and the events that control their levels. Here, we examined the ability of PrPc to cross the BBB in both the blood-to-brain and the brain-to-blood directions.

Capillary depletion

Capillary depletion as modified for use in the mouse (Triguero et al., 1990; Gutierrez et al., 1993) was used to determine the degree to which PrPc was sequestered and retained by the vascular bed of the brain.

I-PrPc was also taken up by the peripheral tissues of spleen, liver, kidney and cervical lymph nodes (Table 2)… there was a statistically significant decrease in the Ki for brain: F(1,8) = 7.97, p <0.05. This demonstrates that transport of PrPc across the BBB involves a saturable transport system.

Fig. 4 shows values for brain and spinal cord regions. Statistical comparison of the whole brain value to brain regions and olfactory bulb (spinal cord regions excluded) showed a statistically significant variation: F(22,62) = 18.3, p <0.001. The hypothalamus, thalamus, and striatum showed statistically (p <0.01) greater uptake in comparison to whole brain. The highest uptake, however, was into the lumbar region of the spinal cord. Inhibition of uptake by unlabeled PrPc (Table 3; p <0.05) was found for whole brain, olfactory bulb, 4 of the 10 brain regions (occipital cortex, thalamus, striatum, and midbrain) and two of the spinal cord regions (cervical and lumbar)…

Fig. 5 Brain-to-blood efflux of PrPc after icv injection. Half-time clearance from brain was 15.7 min. Inset shows that inclusion of unlabeled PrPc in the icv injection increased retention of radioactively labeled PrPc by brain, demonstrating a saturable component
Does aluminum in vaccines have a more sinister plot that is stated?

Differential effect of aluminum on the blood-brain barrier transport of peptides, technetium and albumin.


Aluminum is a neurotoxin capable of altering membrane structure and function. We investigated whether aluminum also can affect saturable transport across membranes using the blood-brain barrier as our model. Mice were given i.p. or i.v. aluminum (up to 100 mg/kg) as the chloride salt and the disappearance from the brain of several centrally administered substances was measured. We found that aluminum rapidly and profoundly inhibited the saturable system that transports the small, N-tyrosinated peptides Tyr-MIF-1 and the enkephalins from the brain to the blood by acting as a noncompetitive inhibitor. In contrast, the disappearance from the brain of technetium pertechnetate (a substance also transported out of the brain by a different saturable system), albumin or D-Tyr-MIF-1 (a stereoisomer of Tyr-MIF-1 that was confirmed not to be transported by the carrier system) was not affected by aluminum. Aluminum also did not alter either the saturable or nonsaturable component of the uptake of Tyr-MIF-1 by erythrocytes. These findings suggest that one mechanism by which aluminum may induce neurotoxicity is by selective alteration of the transport systems of the blood-brain barrier.

Source: http://www.ncbi.nlm.nih.gov/pubmed/2894456


An enkephalin is a pentapeptide involved in regulating nociception in the body. The enkephalins are termed endogenous ligands, as they are internally derived and bind to the body’s opioid receptors. Discovered in 1975, two forms of enkephalin were revealed, one containing leucine (“leu”), and the other containing mathione (“met”). Both are products of the proenkephalin gene.


Endogenous opioid peptides

There are three well-characterized families of opioid peptides produced by the body: enkephalins, endorphines, and dynorphins. The met-enkephalin peptide sequence is coded for by the enkephalin gene; the leu-enkephalin peptide sequence is coded for by both the enkephalin gene and the dynorphin gene.[3] The proopiomelanocortin gene (POMC) also contains the met-enkephalin sequence on the N-terminus of beta-endorphin, but the endorphin peptide is not processed into enkephalin.

Enkephalin receptor

Main article: Opioid recepter
The receptors for enkephalin are the delta opioid receptors. Opioid receptors are a group of G-protein-coupled receptors, with other opioids as ligands as well. The other endogenous opioids are dynorphins (that bind to kappa receptors), endorphines (mu receptors), endomorphins, and nociceptin/orphanin FQ. The opioid receptors are ~40% identical to somatostatin receptors (SSTRs).


Endomorphins, Met-Enkephalin, Tyr-MIF-1, and the P-glycoprotein Efflux System


The P-glycoprotein (P-gp) transport system, responsible for the efflux of many therapeutic drugs out of the brain, recently has been shown to transport the endogenous brain opiate endorphin. We used P-gp knockout mice (Mdr1a) and their controls to determine where P-gp is involved in the saturable efflux systems of four other endogenous opiate-modulating peptides across the blood-brain barrier (BBB). After injection of endomorphin-1 (Tyr-Pro-Trp-Phe-NH2), endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), Met-enkephalin (Tyr-Gly-Gly-Phe-Met-OH), and Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) into the lateral ventricle of the mouse brain, residual radioactivity was measured at 0, 2, 5, 10, and 20 min later. The results showed no difference in the disappearance of any of these peptides from the brains of knockout mice compared with their controls. This demonstrates that unlike endorphin and morphine, P-gp does not seem to be required for the brain-to-blood transport of the endomorphins, Met-enkephalin, or Tyr-MIF-1 across the BBB.


  • This work was supported by the United States Army Medical Research Acquisition Activity (DAMD17-00-0113) and the Department of Veterans Affairs.

Source: http://dmd.aspetjournals.org/content/30/3/231.abstract


Endorphins (“endogenous morphine”) are endogenous opioid inhibitory neuropeptides. They are produced by the central nervous system and pituitary gland. The term implies a pharmacological activity (analogous to the activity of the corticosteroid category of biochemicals) as opposed to a specific chemical formulation. It consists of two parts: endo- and -orphin; these are short forms of the words endogenous and morphine, intended to mean “a morphine-like substance originating from within the body.”[1]


Opioid neuropeptides were first discovered in 1974 by two independent groups of investigators:

  • John Hughes and Hans Kosterlitz of Scotland isolated — from the brain of a pig — what some called enkephalins (from the Greek εγκέφαλος, cerebrum).[2][3]
  • Around the same time, in a calf brain, Rabi Simantov and Solomon H. Snyder of the United States found[4] what Eric Simon (who independently discovered opioid receptors in vertebral brains) later termed “endorphin” by an abreviation of of “endogenous morphine”, meaning “morphine produced naturally in the body”.[1] Importantly, recent studies have demonstrated that human and diverse animal tissues are in fact capable of producing morphine itself, which is not a peptide.[5][6]

Mechanism of action

Beta-endorphin (β-endorphin) is released into blood from the pituitary gland and into the spinal cord and brain from hypothalamic neurons. The β-endorphin that is released into the blood cannot enter the brain in large quantities because of the blood-brain barrier, so the physiological importance of the β-endorphin that can be measured in the blood is far from clear. β-endorphin is a cleavage product of pro-opiomelanocortin (POMC), which is also the precursor hormone for adrenocorticotrophic hormone (ACTH). The behavioural effects of β-endorphin is exerted by its actions in the brain and spinal cord, and it is presumed that the hypothalamic neurons are the major source of β-endorphin at those sites. In situations where the level of ACTH is increased (e.g., Cushing’s disease), the level of β-endorphin also increases slightly.

β-endorphin has the highest affinity for the μ1 opioid receptor, slightly lower affinity for the μ2 and δ opioid receptors, and low affinity for the κ1 opioid receptors. μ-Opioid receptors are the main receptor through which morphine acts. In the classical sense, μ opioid receptors are presynaptic, and inhibit neurotransmitter release. Through that mechanism, they inhibit the release of the inhibitory neurotransmitter GABA, and disinhibit the dopamine pathways, causing more dopamine to be released. By hijacking this process, exogenous opioids cause inappropriate dopamine release, and can lead to aberrant synaptic plasticity, which can cause dependency. Opioid receptors have many other and more important roles in the brain and periphery; however, modulating pain, cardiac, gastric and vascular function as well as possibly panic and satiation. Also, receptors are often found at postsynaptic locations as well as at presynaptic locations…


Morphine preconditioning reduces lipopolysaccharide and interferon-γ-induced mouse microglial cell injury via δ1 opioid receptor activation


Microglial cells play an important role in the inflammatory response of a broad range of brain diseases including stroke, brain infection and neurodegenerative diseases. However, there is very little information regarding how to protect microglial cells. Here, we showed that incubation of the C8-B4 mouse microglial cells with lipopolysaccharide (LPS) plus interferon-γ (IFNγ) induced cytotoxicity as assessed by the amount of lactate dehydrogenase (LDH) released from the cells. Preconditioning the cells with morphine for 30 min concentration-dependently reduced LPS plus IFNγ-induced cell injury. This morphine preconditioning effect was abolished by naloxone, a general opioid receptor antagonist, by naltrindole, a selective δ opioid receptor antagonist and by 7-benzylidenenaltrexone maleate, a selective δ1 opioid receptor antagonist. However, this protective effect was not affected by β-funaltrexamine, a selective μ opioid receptor antagonist, nor-binaltorphimine, a selective κ opioid receptor antagonist or naltriben, a selective δ2 opioid receptor antagonist. LPS plus IFNγ induced the expression of inducible nitric oxide synthase (iNOS), which was not affected by morphine preconditioning. Our results suggest that morphine induced a preconditioning effect in microglial cells. This effect may be mediated by δ1 opioid receptors and may not be through inhibiting the expression of iNOS, a potentially harmful protein.

Source–> http://www.sciencedirect.com/science/article/pii/S0306452210002137


Prion peptide PrP106-126 induces inducible nitric oxide synthase (iNOS) and proinflammatory cytokine gene expression through the activation of NF-kB in macrophage cells

The inflammatory response in prion diseases is dominated by microglia activation. The molecular mechanisms that lie behind this inflammatory process are not very well understood. In the present study, we examined the activation of nuclear factor-kappa B (NF-κB) upon exposure to PrP106-126 and its role in PrP106-126-induced upregulation of inducible nitric oxide synthase (iNOS) and proinflammatory cytokines (interleukin [IL]-1β, tumor necrosis factor [TNF]-α, IL-6) in Ana-1 macrophages. The results showed that iNOS and proinflammatory cytokine release was significantly elevated in Ana-1 macrophages upon exposure to PrP106-126; that PrP106-126 treatment led to a significant NF-κB activation; that proinflammatory cytokines gene expression was elevated in macrophages upon exposure to PrP106-126; and that NF-κB inhibition significantly abrogated PrP106-126-induced upregulation of iNOS and inflammatory cytokine mRNA expression. These results suggest that treatment with neurotoxic prion peptides leads to the activation of transcription factor NF-κB, which in turn stimulates gene expression of iNOS and proinflammatory cytokines in Ana-1 macrophages.

Source–> http://www.pubfacts.com/detail/22149924/Prion-peptide-PrP106-126-induces-inducible-nitric-oxide-synthase-and-proinflammatory-cytokine-gene-e


The Transcription Factor Nuclear Factor-kappa B and Cancer


Since the discovery of nuclear factor-kappa B (NF-κB) in 1986, many studies have been conducted showing the link between the NF-κB signalling pathway and control of the inflammatory response. Today it is well known that control of the inflammatory response and apoptosis is closely related to the activation of NF-κB. Three NF-κB activation pathways exist. The first (the classical pathway) is normally triggered in response to microbial and viral infections or exposure to pro-inflammatory cytokines that activate the tripartite IKK complex, leading to phosphorylation-induced IκB degradation and depends mainly on IKKβ activity. The second (the alternative pathway), leads to selective activation of p52:RelB dimers by inducing the processing of the NF-κB2/p100 precursor protein, which mostly occurs as a heterodimer with RelB in the cytoplasm. This pathway is triggered by certain members of the tumour necrosis factor cytokine family, through selective activation of IKKα homodimers by the upstream kinase NIK. The third pathway is named CK2 and is IKK independent. NF-κB acts through the transcription of anti-apoptotic proteins, leading to increased proliferation of cells and tumour growth. It is also known that some drugs act directly in the inhibition of NF-κB, thus producing regulation of apoptosis; some examples are aspirin and corticosteroids. Here we review the role of NF-κB in the control of apoptosis, its link to oncogenesis, the evidence of several studies that show that NF-κB activation is closely related to different cancers, and finally the potential target of NF-κB as cancer therapy.

Source–> http://www.sciencedirect.com/science/article/pii/S0936655506004274


Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology


• NF-κB signaling in MS patients and animal models of MS.
NF-κB signaling controls peripheral immune activation at multiple levels.
NF-κB controls inflammatory responses locally in the CNS.
• NF-κB as a therapeutic target for the treatment of MS.

The nuclear factor kappa B (NF-κB) signaling cascade plays a critical role in the regulation of immune and inflammatory responses and has been implicated in the pathogenesis of autoimmune demyelinating diseases such as multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), the main animal model of MS. NF-κB is essential for peripheral immune cell activation and the induction of pathology, but also plays crucial roles in resident cells of the central nervous system (CNS) during disease development. Here we review recent evidence clarifying the role of NF-κB in the different cell compartments contributing to MS pathology and its implications for the development of therapeutic strategies for the treatment of MS and other demyelinating pathologies of the CNS.

Source–> http://www.sciencedirect.com/science/article/pii/S1471491413001330


NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet radiation, oxidized LDL, and bacterial or viral antigens.[1][2][3][4][5] NF-κB plays a key role in regulating the immune response to infection (k light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory, and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.[6][7][8][9][10]

In brief, NF-κB can be understood to be a protein responsible for cytokine production and cell survival.


All proteins of the NF-κB family share a Rel homology domain in their N-terminus. A subfamily of NF-κB proteins, including RelA, RelB, and c-Rel, have a transactivation domain in their C-termini. In contrast, the NF-κB1 and NF-κB2 proteins are synthesized as large precursors, p105, and p100, which undergo processing to generate the mature NF-κB subunits, p50 and p52, respectively. The processing of p105 and p100 is mediated by the ubiquitin/proteasome pathway and involves selective degradation of their C-terminal region containing ankyrin repeats. Whereas the generation of p52 from p100 is a tightly regulated process, p50 is produced from constitutive processing of p105.[12][13] The p50 and p52 proteins have no intrinsic ability to activate transcription and thus have been proposed to act as transcriptional repressors when binding κB elements as homodimers.[14][15] Indeed, this confounds the interpretation of p105-knockout studies, where the genetic manipulation is removing an IκB (full-length p105) and a likely repressor (p50 homodimers) in addition to a transcriptional activator (the RelA-p50 heterodimer).


NF-κB family members share structural homology with the retroviral oncoprotein v-Rel, resulting in their classification as NF-κB/Rel proteins.[1]

There are five proteins in the mammalian NF-κB family:[16]

Species distribution and evolution

In addition to mammals, NF-κB is found in a number of simple animals as well.[17] These include cnidarians (such as sea anemones, coral and hydra), porifera (sponges), the single-celled eukaryote Capsaspora owczarzaki and insects (such as moths, mosquitoes, and fruit flies). The sequencing of the genomes of the mosquitoes A. aegypti and A. gambiae, and the fruitfly D. melangaster has allowed comparative genetic and evolutionary studies on NF-κB. In those insect species, activation of NF-κB is triggered by the Toll pathway (which evolved independently in insects and mammals) and by the Imd (immune deficiency) pathway.[18]

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors usually expressed in sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes. Once these microbes have breached physical barriers such as the skin or intestinal tract mucosa, they are recognized by TLRs, which activate immune cell responses



NF-κB (green) heterodimerizes with RelB (cyan) to form a ternary complex with DNA (orange) that promotes gene transcription.[19]

NF-κB is important in regulating cellular responses because it belongs to the category of “rapid-acting” primary transcription factors, i.e., transcription factors that are present in cells in an inactive state and do not require new protein synthesis in order to become activated (other members of this family include transcription factors such as c-Jun, STATs, and nuclear hormone receptors). This allows NF-κB to be a first responder to harmful cellular stimuli. Known inducers of NF-κB activity are highly variable and include reactive oxygen species (ROS), tumor necrosis factor alpha (TNFa), interleukin 1-beta (IL1β), bacterial lipopolysaccharides (LPS), isoproterenol, cocaine, and ionizing radiation.[20]

Receptor activator of NF-κB (RANK), which is a type of TNFR, is a central activator of NF-κB. Osteoprotegerin (OPG), which is a decoy receptor homolog for RANK ligand, inhibits RANK by binding to RANKL, and, thus, osteoprotegerin is tightly involved in regulating NF-κB activation.[21]

Many bacterial products and stimulation of a wide variety of cell-surface receptors lead to NF-κB activation and fairly rapid changes in gene expression.[1] The identification of Toll-like receptors(TLRs) as specific pattern recognition molecules and the finding that stimulation of TLRs leads to activation of NF-κB improved our understanding of how different pathogens activate NF-κB. For example, studies have identified TLR4 as the receptor for the LPS component of Gram-negative bacteria.[22] TLRs are key regulators of both innate and adaptive immune responses.[23]

Unlike RelA, RelB, and c-Rel, the p50 and p52 NF-κB subunits do not contain transactivation domains in their C terminal halves. Nevertheless, the p50 and p52 NF-κB members play critical roles in modulating the specificity of NF-κB function. Although homodimers of p50 and p52 are, in general, repressors of κB site transcription, both p50 and p52 participate in target gene transactivation by forming heterodimers with RelA, RelB, or c-Rel.[24] In addition, p50 and p52 homodimers also bind to the nuclear protein Bcl-3, and such complexes can function as transcriptional activators.[25][26][27]


In unstimulated cells, the NF-κB dimers are sequestered in the cytoplasm by a family of inhibitors, called IκBs (Inhibitor of κB), which are proteins that contain multiple copies of a sequence called ankyrin repeats. By virtue of their ankyrin repeat domains, the IκB proteins mask the nuclear localization signals (NLS) of NF-κB proteins and keep them sequestered in an inactive state in the cytoplasm.[28]

IκBs are a family of related proteins that have an N-terminal regulatory domain, followed by six or more ankyrin repeats and a PEST domain near their C terminus. Although the IκB family consists of IκBα, IκBβ, IκBε, and Bcl-3, the best-studied and major IκB protein is IκBα. Due to the presence of ankyrin repeats in their C-terminal halves, p105 and p100 also function as IκB proteins. The c-terminal half of p100, that is often referred to as IκBδ, also functions as an inhibitor.[29][30] IκBδ degradation in response to developmental stimuli, such as those transduced through LTβR, potentiate NF-κB dimer activation in a NIK dependent non-canonical pathway.[29][31]

Activation of the NF-κB is initiated by the signal-induced degradation of IκB proteins. This occurs primarily via activation of a kinase called the IκB kinase (IKK). IKK is composed of a heterodimer of the catalytic IKKα and IKKβ subunits and a “master” regulatory protein termed NEMO (NF-κB essential modulator) or IKK gamma. When activated by signals, usually coming from the outside of the cell, the IκB kinase phosphorylates two serine residues located in an IκB regulatory domain. When phosphorylated on these serines (e.g., serines 32 and 36 in human IκBα), the IκB inhibitor molecules are modified by a process called ubiquitination, which then leads them to be degraded by a cell structure called the proteasome.

With the degradation of IκB, the NF-κB complex is then freed to enter the nucleus where it can ‘turn on’ the expression of specific genes that have DNA-binding sites for NF-κB nearby. The activation of these genes by NF-κB then leads to the given physiological response, for example, an inflammatory or immune response, a cell survival response, or cellular proliferation. NF-κB turns on expression of its own repressor, IκBα. The newly synthesized IκBα then re-inhibits NF-κB and, thus, forms an auto feedback loop, which results in oscillating levels of NF-κB activity.[32] In addition, several viruses, including the AIDS virus HIV, have binding sites for NF-κB that controls the expression of viral genes, which in turn contribute to viral replication or viral pathogenicity. In the case of HIV-1, activation of NF-κB may, at least in part, be involved in activation of the virus from a latent, inactive state.[33] YopP is a factor secreted by Yersinia pestis, the causative agent of plague, that prevents the ubiquitination of IκB. This causes this pathogen to effectively inhibit the NF-κB pathway and thus block the immune response of a human infected with Yersinia.[34]

Inhibitors of NF-κB activity

Concerning known protein inhibitors of NF-κB activity, one of them is IFRD1, which represses the activity of NF-κB p65 by enhancing the HDAC-mediated deacetylation of the p65 subunit at lysine 310, by favoring the recruitment of HDAC3 to p65. In fact IFRD1 forms trimolecular complexes with p65 and HDAC3.[35][36]


A select set of cell-differentiating or developmental stimuli, such as lymphotoxin-α, BAFF or RANKL, activate the non-canonical NF-κB pathway to induce NF-κB/RelB:p52 dimer in the nucleus. In this pathway, activation of the NF-κB inducing kinase (NIK) upon receptor ligation led to the phosphorylation and subsequent proteasomal processing of the NF-κB2 precursor protein p100 into mature p52 subunit in an IKK1/IKKa dependent manner. Then p52 dimerizes with RelB to appear as a nuclear RelB:p52 DNA binding activity and regulate a distinct class of genes.[37] In contrast to the canonical signaling that relies upon NEMO-IKK2 mediated degradation of IκBα, -β, -ε, the non-canonical signaling critically depends on NIK mediated processing of p100 into p52. Given their distinct regulations, these two pathways were thought to be independent of each other. However, recent analyses revealed that synthesis of the constituents of the non-canonical pathway, viz RelB and p52, is controlled by the canonical IKK2-IκB-RelA:p50 signaling.[38] Moreover, generation of the canonical and non-canonical dimers, viz RelA:p50 and RelB:p52, within the cellular milieu are also mechanistically interlinked.[38] These analyses suggest that an integrated NF-κB system network underlies activation of both RelA and RelB containing dimer and that a malfunctioning canonical pathway will lead to an aberrant cellular response also through the non-canonical pathway.

In immunity

NF-κB is a major transcription factor that regulates genes responsible for both the innate and adaptive immune response. Upon activation of either the T- or B-cell receptor, NF-κB becomes activated through distinct signaling components. Upon ligation of the T-cell receptor, protein kinase Lck is recruited and phosphorylates the ITAMs of the CD3 cytoplasmic tail. ZAP70 is then recruited to the phosphorylated ITAMs and helps recruit LAT and PLC-γ, which causes activation of PKC. Through a cascade of phosphorylation events, the kinase complex is activated and NF-κB is able to enter the nucleus to upregulate genes involved in T-cell development, maturation, and proliferation.[39]

In the nervous system

In addition to roles in mediating cell survival, studies by Mark Mattson and others have shown that NF-κB has diverse functions in the nervous system including roles in plasticity, learning, and memory. In addition to stimuli that activate NF-κB in other tissues, NF-κB in the nervous system can be activated by Growth Factors (BDNF, NGF) and synaptic transmission such as glutamate.[7] These activators of NF-κB in the nervous system all converge upon the IKK complex and the canonical pathway.

Recently there has been a great deal of interest in the role of NF-κB in the nervous system. Current studies suggest that NF-κB is important for learning and memory in multiple organisms including crabs,[9][10] fruit flies,[40] and mice.[7][8] NF-κB may regulate learning and memory in part by modulating synaptic plasticity,[6][41] synapse function,[40][42][43] as well as by regulating the growth of dendrites[44] and dendritic spines.[43]

Genes that have NF-κB binding sites are shown to have increased expression following learning,[8] suggesting that the transcriptional targets of NF-κB in the nervous system are important for plasticity. Many NF-κB target genes that may be important for plasticity and learning include growth factors (BDNF, NGF)[45] cytokines (TNF-alpha, TNFR)[46] and kinases (PKAc).[41]

Despite the functional evidence for a role for Rel-family transcription factors in the nervous system, it is still not clear that the neurological effects of NF-κB reflect transcriptional activation in neurons. Most manipulations and assays are performed in the mixed-cell environments found in vivo, in “neuronal” cell cultures that contain significant numbers of glia, or in tumor-derived “neuronal” cell lines. When transfections or other manipulations have been targeted specifically at neurons, the endpoints measured are typically electrophysiology or other parameters far removed from gene transcription. Careful tests of NF-κB-dependent transcription in highly purified cultures of neurons generally show little to no NF-κB activity.[47][48] Some of the reports of NF-κB in neurons appear to have been an artifact of antibody nonspecificity.[49] Of course, artifacts of cell culture—e.g., removal of neurons from the influence of glia—could create spurious results as well. But this has been addressed in at least two coculture approaches. Moerman et al.[50] used a coculture format whereby neurons and glia could be separated after treatment for EMSA analysis, and they found that the NF-κB induced by glutamatergic stimuli was restricted to glia (and, intriguingly, only glia that had been in the presence of neurons for 48 hours). The same investigators explored the issue in another approach, utilizing neurons from an NF-κB reporter transgenic mouse cultured with wild-type glia; glutamatergic stimuli again failed to activate in neurons.[51] Some of the DNA-binding activity noted under certain conditions (particularly that reported as constitutive) appears to result from Sp3 and Sp4 binding to a subset of κB enhancer sequences in neurons.[52] This activity is actually inhibited by glutamate and other conditions that elevate intraneuronal calcium. In the final analysis, the role of NF-κB in neurons remains opaque due to the difficulty of measuring transcription in cells that are simultaneously identified for type. Certainly, learning and memory could be influenced by transcriptional changes in astrocytes and other glial elements. And it should be considered that there could be mechanistic effects of NF-κB aside from direct transactivation of genes.

Clinical significance

Overview of signal transduction pathways involved in apoptosis.


NF-κB is widely used by eukaryotic cells as a regulator of genes that control cell proliferation and cell survival. As such, many different types of human tumors have misregulated NF-κB: that is, NF-κB is constitutively active. Active NF-κB turns on the expression of genes that keep the cell proliferating and protect the cell from conditions that would otherwise cause it to die via apoptosis.

Defects in NF-κB results in increased susceptibility to apoptosis leading to increased cell death. This is because NF-κB regulates anti-apoptotic genes especially the TRAF1 and TRAF2 and, therefore, checks the activities of the caspase family of enzymes, which are central to most apoptotic processes.[53]

In tumor cells, NF-κB is active either due to mutations in genes encoding the NF-κB transcription factors themselves or in genes that control NF-κB activity (such as IκB genes); in addition, some tumor cells secrete factors that cause NF-κB to become active. Blocking NF-κB can cause tumor cells to stop proliferating, to die, or to become more sensitive to the action of anti-tumor agents. Thus, NF-κB is the subject of much active research among pharmaceutical companies as a target for anti-cancer therapy.[54]

However, caution should be exercised when considering anti-NF-κB activity as a broad therapeutic strategy in cancer therapy, even though convincing experimental data have identified NF-κB as a critical promoter of cancer development, creating a solid rationale for the development of antitumor therapy that suppresses NF-κB activity. Data have also shown that NF-κB activity enhances tumor cell sensitivity to apoptosis and senescence. In addition, it has been shown that canonical NF-κB is a Fas transcription activator and the alternative NF-κB is a Fas transcription repressor.[55] Therefore, NF-κB promotes Fas-mediated apoptosis in cancer cells, and thus inhibition of NF-κB may suppress Fas-mediated apoptosis to impair host immune cell-mediated tumor suppression.


Because NF-κB controls many genes involved in inflammation, it is not surprising that NF-κB is found to be chronically active in many inflammatory diseases, such as inflammatory bowel disease, arthritis, sepsis, gastritis, asthma, atherosclerosis[56] and others. It is important to note though, that elevation of some NF-κB inhibitors, such as osteoprotegerin (OPG), are associated with elevated mortality, especially from cardiovascular diseases.[57][58] Elevated NF-κB has also been associated with schizophrenia.[59] Recently, NF-κB activation has been suggested as a possible molecular mechanism for the catabolic effects of cigarette smoke in skeletal muscle and sarcopenia.[60]

Non-drug inhibitors

Many natural products (including anti-oxidants) that have been promoted to have anti-cancer and anti-inflammatory activity have also been shown to inhibit NF-κB.[61][62] There is a controversial US patent (US patent 6,410,516)[63] that applies to the discovery and use of agents that can block NF-κB for therapeutic purposes. This patent is involved in several lawsuits, including Ariad v. Lilly. Recent work by Karin,[64] Ben-Neriah[65] and others has highlighted the importance of the connection between NF-κB, inflammation, and cancer, and underscored the value of therapies that regulate the activity of NF-κB.[66]

Extracts from a number of herbs and dietary plants are efficient inhibitors of NF-κB activation in vitro.[67][68][69]

The circumsporozoite protein of Plasmodium falciparum has been shown to be an inhibitor of NF-κB.[70]

As a drug target

Aberrant activation of NF-κB is frequently observed in many cancers. Moreover, suppression of NF-κB limits the proliferation of cancer cells. In addition, NF-κB is a key player in the inflammatory response. Hence methods of inhibiting NF-κB signaling has potential therapeutic application in cancer and inflammatory diseases.[71][72]

The discovery that activation of NF-κB nuclear translocation can be separated from the elevation of oxidant stress[73] gives an important hint to the development of strategies for NF-κB inhibition.

A new drug called denosumab acts to raise bone mineral density and reduce fracture rates in many patient sub-groups by inhibiting RANKL. RANKL acts through its receptor RANK, which in turn promotes NF-κB,[74] RANKL normally works by enabling the differentiation of osteoclasts from monocytes.

Disulfiram, olmesartan and dithiocarbamates can inhibit the nuclear factor-κB (NF-κB) signaling cascade.[75]

Anatabine’s antiinflammatory effects are claimed to result from modulation of NF-κB activity.[76] However the studies purporting its benefit use abnormally high doses in the millimolar range (similar to the extracellular potassium concentration), which are unlikely to be achieved in humans.



Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene.[1]

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S  proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappaB (NF-kB) protein complex. NF-κB is a transcription factor that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NF-κB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions; over 200 known genes are targets of NF-κB in various cell types, under specific conditions. Inappropriate activation of NF-κB has been associated with a number of inflammatory diseases while persistent inhibition of NF-κB leads to inappropriate immune cell development or delayed cell growth.[2]


Signal Transduction Through Prion Protein

The cellular prion protein PrPc is a glycosylphosphatidylinositol-anchored cell-surface protein whose biological function is unclear. We used the murine 1C11 neuronal differentiation model to search for PrPc-dependent signal transduction through antibody-mediated cross-linking. A caveolin-1–dependent coupling of PrPc to the tyrosine kinase Fyn was observed. Clathrin might also contribute to this coupling. The ability of the 1C11 cell line to trigger PrPc-dependent Fyn activation was restricted to its fully differentiated serotonergic or noradrenergic progenies. Moreover, the signaling activity of PrPc occurred mainly at neurites. Thus, PrPc may be a signal transduction protein.

Science 15 September 2000:
Vol. 289
no. 5486 pp. 19251928

A cellular gene encodes scrapie PrP 27-30 protein.


A clone encoding PrP 27-30, the major protein in purified preparations of scrapie agent, was selected from a scrapie-infected hamster brain cDNA library by oligonucleotide probes corresponding to the N terminus of the protein. Southern blotting with PrP cDNA revealed a single gene with the same restriction patterns in normal and scrapie-infected brain DNA. A single PrP-related gene was also detected in murine and human DNA. PrP-related mRNA was found at similar levels in normal and scrapie-infected hamster brain, as well as in many other normal tissues. Using antisera against PrP 27-30, a PrP-related protein was detected in crude extracts of infected brain and to a lesser extent in extracts of normal brain. Proteinase K digestion yielded PrP 27-30 in infected brain extract, but completely degraded the PrP-related protein in normal brain extract. No PrP-related nucleic acids were found in purified preparations of scrapie prions, indicating that PrP 27-30 is not encoded by a nucleic acid carried within the infectious particles.

Source–> http://www.ncbi.nlm.nih.gov/pubmed/2859120


Identification of Chemoattractive Factors Involved in the Migration of Bone Marrow-Derived Mesenchymal Stem Cells to Brain Lesions Caused by Prions


Bone marrow-derived mesenchymal stem cells (MSCs) have been reported to migrate to brain lesions of neurodegenerative diseases; however, the precise mechanisms by which MSCs migrate remain to be elucidated. In this study, we carried out an in vitro migration assay to investigate the chemoattractive factors for MSCs in the brains of prion-infected mice. The migration of immortalized human MSCs (hMSCs) was reduced by their pretreatment with antibodies against the chemokine receptors, CCR3, CCR5, CXCR3, and CXCR4 and by pretreatment of brain extracts of prion-infected mice with antibodies against the corresponding ligands, suggesting the involvement of these receptors, and their ligands in the migration of hMSCs. In agreement with the results of an in vitro migration assay, hMSCs in the corpus callosum, which are considered to be migrating from the transplanted area toward brain lesions of prion-infected mice, expressed CCR3, CCR5, CXCR3, and CXCR4. The combined in vitro and in vivo analyses suggest that CCR3, CCR5, CXCR3, and CXCR4, and their corresponding ligands are involved in the migration of hMSCs to the brain lesions caused by prion propagation. In addition, hMSCs that had migrated to the right hippocampus of prion-infected mice expressed CCR1, CX3CR1, and CXCR4, implying the involvement of these chemokine receptors in hMSC functions after chemotactic migration. Further elucidation of the mechanisms that underlie the migration of MSCs may provide useful information regarding application of MSCs to the treatment of prion diseases.


Prion diseases are fatal neurodegenerative disorders in humans and animals that are characterized by the accumulation of a disease-specific isoform of the prion protein (PrPSc), astrocytosis, microglial activation, spongiosis, and neuronal cell death in the central nervous system (CNS). Although the etiology of the diseases is not clear, conversion of the normal prion protein to PrPSc plays a key role in the neuropathological changes (44). Therefore, compounds that inhibit PrPSc formation are considered as therapeutic candidates of the diseases, and many compounds have been reported to inhibit PrPSc formation in cell cultures and cell-free systems (reviewed in reference 56). However, only a few of these inhibitors, such as amphotericin B and its derivative (13), pentosan polysulfate (14), porphyrin derivatives (27), certain amyloidophilic compounds (25), and FK506 (37) have been reported to prolong the survival of prion-infected mice even when administered in the middle-late stage of infection but still before clinical onset. We recently reported that intraventricular infusion of anti-PrP antibodies (50) slowed down the progression of the disease even when initiated just after clinical onset. However, in addition to inhibition of PrPSc formation, the protection of neurons or restoration of degenerated neurons is thought to be important for functional recovery.

Bone marrow-derived mesenchymal stem cells (MSCs) differentiate into cells of mesodermal origin such as adipocytes, osteoblasts, and endothelial and muscle cells (41, 43). In addition, MSCs are known to transdifferentiate into neuronal and glial cells. MSCs have been shown to migrate to damaged neuronal tissues and to alleviate the deficits in experimental animal models of cerebral ischemia (10), spinal cord injury (20), Parkinson’s disease (19, 33), and amyotrophic lateral sclerosis (59). MSCs also secrete various neurotrophic factors that may protect neuronal tissues from degradations, as well as stimulate the activity of endogenous neural stem cells (38). Therefore, despite their mesodermal origin, MSCs are considered to be a candidate for cell-mediated therapy for neurodegenerative diseases. One of the characteristics of MSCs is their migration to brain lesions caused by neurodegenerative diseases, including prion diseases (10, 19, 39, 51). This feature may be of further use for cell-mediated therapy of neurodegenerative diseases, particularly for prion diseases, Multiple sclerosis and Alzheimer’s disease, which have diffuse pathological lesions.

Since many cytokines, chemokines, and adhesion molecules are involved in the homing of immune cells (9, 36, 53), evidence that a variety of chemokines and growth factors, as well as their cognate receptors, have a pivotal role in the migration of MSCs has been accumulated. These factors include CXCL12 and its receptor CXCR4 (30, 40; reviewed in reference 52), CCL2 (15, 62, 66), CCL3 (62), interleukin-8 (48, 62), hepatocyte growth factor (16), platelet-derived growth factor AB (PDGF-AB), insulin-like growth factor 1 (IGF-1), CCL5 and CCL22 (42), and integrin β1 (23). Regarding the migration of MSCs to injury in the CNS, the involvement of CCL2 (61), CXCL12/CXCR4, and CX3CL1/CX3CR1 (24) has been reported. However, knowledge of the mechanism by which MSCs migrate to pathological lesions of neurodegenerative diseases is insufficient, and further efforts are required to elucidate this mechanism.

We recently reported that human MSCs (hMSCs) migrate to CNS lesions and prolong the survival of mice infected with prions (51). In the present study, we investigated factors that are involved in the migration of hMSCs to brain lesions of prion diseases.

Source–> http://jvi.asm.org/content/85/21/11069.full


To say that the body is one giant communication system is an understatement. The expression of genes and the ability for host cells to operate normally and to chemically call for help when faced with an antigen is esential to health. As discussed above, these prion interferors with the interferon and other defensive signaling processes must be injected to bypass the mucosus and the skin. This can only be accomplished through innoculation and vaccination.

The introduction of foreign proteins and DNA/RNA into the otherwise healthy body is certainly described here as the cause of most disease states in modern times. And from the time that this interferon was discovered, these psychopathic scientists have been working overtime to prevent our bodies from being able to fight what they inject.

What you have just read is the cause and cure for AIDS, cancers, dementias, and a host of other modern medically-induced disease states that revolve around prion infection and misfolding of the signal processing of the body. It is not so much a cure as an acknowledgement of the cause, for when disease is purposefully caused, the word cure seems trivial in practice, and allows the culprits to literally get away with murder.

It was caused by them…

Will we sit by helplessly and hope for a cure to these purposefully caused diseases by the very perpetrators of them?

Isn’t that the American way though?

For as we wait, they merely perfect their science of biological aggression and warfare…

(Note: all unlinked data as descriptions above from Wikipedia, which are well-sourced within that site.)


–Clint Richardson (realitybloger.wordpress.com)
–Thursday, December 4rth, 2014

Confessions Of A Former Truther


In Defense Of The Stupid: Perspectives By A Reformed Truther

To varying degrees, those who imagine that they have taken part in the popular alternative media notion that they have “woken up” begin to reference the majority of the remaining population as stupid. Zombies. Sheep. I suppose this is simply a sophomoric way of distinguishing one’s self from those who have not learned what the individual or group has learned – a surreal sense of self-entitled elitism for the collective minority stake of disenfranchised denizens. And yet these supposedly now “elite” members of the woken up club will be the first to retain an attorney when their still enslaved legal persona is in legal harm’s way.

When politically things don’t go the way the woken up wish that they would in their outreach and activism, these “truthers” inevitably blame the un-indoctrinated mass of stupid people, which always seems to represent the faceless majority of the population out there that isn’t part of the truther network. If only the woken up were running things, everything would be peachy keen…

In all cases the problems of the world seem to stem from the collective stupidity of the rest of the race of man, of which the woken up seem to believe they are somehow no longer a part of in classic class-oriented stylings. Thus far, I have not been privy to any written test or other indicator of just who is awake and who is stupid and not awake. But it seems to be that the stupid people are the ones whom either disagree with or just wont listen to the awakened and their insistent truth.

The woken up carry an invisible torch that represents their perceived awareness for which they call ultimately “the truth”. They are indeed the self-labeled “truthers,” as if all else in stupid-land is not truth. In fact, about a single subject like 9-11-2001, these woken up truthers can have among them literally dozens of different and disagreeable “truths” for which they spew as somehow the one and only truth. There were planes on that day and there were also no planes. There were holograms and there were missiles. It was bombs and it was energy weapons. It was Israeli Mossad and it was the CIA. Bush was merely complicit and Bush pulled the trigger himself…

Anyone in stupid-ville presented with such vast varieties of the truth from such a woken up class of alternative misfits would certainly be more repulsed to the truth than accepting of it, which is exactly where I found myself as I listened to the rantings and ravings of my fellow truthers. Inevitably, when this public repulsion manifests in the form of them asking unanswerable questions or their denial of that presented truth by the apparently awakened people, the awakened get just as angry and fallacious in their response and repose as their apparently stupid counterparts in their own defensive dispositions. At this point the ad hominem attack creeps in from the unawares, and terms like sheeple, ignorant, and stupid are spewed in between truths.

No one would sanely argue over what is reality. But truth has many different flavors, being merely the perception of reality based on the learned knowledge of the subject of a particular thing in reality. Truth changes with different opinions. Reality exists despite any opinion.

Interestingly, woken up individuals must first and foremost admit that in order to become one of the awakened, one must first have been one of the apparently stupid. Though there is no merit badge, this turning point in the personal comprehension of one’s disposition and transformation from one of the stupid to one of the awake never seems to have an inception point. It is more so a leap of faith than an initiation into the truther club; an incremental change of paradigm and self-aggrandizement. It requires nothing really but a change of attitude; or more to the point, a change of perspective. But most important are the words and terms of art that come with that transference, for the elite always have their own artifice. Stupid is one of those terms. For suddenly the notion of independence from the stupid masses becomes a pertinent requirement of the awakening process. And slowly everything becomes murkily clear – all of the problems in the world seem to rest not on one’s self, but instead on the amorphous blob of stupid people out there.

This is apparently the 1st (and sadly often times the last) level of the awakening process.

And a truther one becomes…

It doesn’t matter that as a member of the awake club one has only actually physically met about 0.00000001% of the entire population of all of those people that are supposedly the stupid sheep out there. All that matters is that the awakened have come to a consensus that everyone else is stupid but us, no matter how irrational that notion actually is, and that this is the central division point in society between them, us, and they. This generality does not consider the notion that many of those stupid people have never heard the religion of truth from the awakened through digital and printed media. Thus, many are stupid sheerly because of the non-availability of information called “truth”. But we find that this is no excuse, for just like fundamentalist Christian folk the awake believe that everyone must have access to the truth – that the truth is universal – and so all of stupidity as a culture must therefore be simply in denial of the truth.

If I’m not mistaken, I think the same thing happened when the Christian settlers came to America and discovered not the just the land, but that the true native inhabitants of that land had never heard of Christ; and suddenly the universal truth of the church was not so universal after all. And so how does history go…? Better to kill these stupid natives than to admit that a different truth may indeed exist than the truth of the corporate church and its professors (truthers)… Or perhaps it was that the settlers didn’t actually have the whole truth, which would mean integration of cultural ideals that might defeat the percieved truth of the church! After all, it’s not like anybody on this secular Earth ever has all truth…

Ultimately, the life of a truther becomes more and more secluded, introverted, and lonely. After living in Manhattan for several years, I can certainly attest that one can be extremely lonely in a city of millions upon millions of lost souls; even when they are stacked up on top of each other like oily sardines. When one of the awakened finds that most people look at him as if he is speaking a foreign language as he tries to force his own brand of truth down the stupid people’s throats, a unique anxiety begins to develop that steers the truther into an even more “outside-the-box” feeling, while ultimately still being just as stuck within the box as the rest of us. After a while, the awakened realize that each of their fellow awakened elites seem to have different opinions about what the truth actually is, often in contradiction to each other. They begin to argue with one another instead of with the stupid people as they sit in meeting circles within public library rooms and relish a dream of change that they cannot ever seem to evoke.

Truth will create the change, if we could just agree on what the truth is and then not piss people off by forcibly “sharing” it with them while they are trying to enjoy what little joy life has to offer in some public park or boardwalk. Surely the stupid people came out to hear truth from the truth brigade, not just to enjoy the ocean view or play with their own children in spiritual happiness. And so like illegals on the Las Vegas strip flashing nudie adverts and hustling ads for prostitution and tittie bars, the awakened flash their own propoganda while insulting those who don’t bite the lure.

Once in a while one of the awakened actually wakes up a bit more than they are supposed to when they realize that none in their group actually seems to comprehend the actual reality of things, and that for the most part they are all looking for the same answers to the same questions that you and the other stupid people are. And so what at first was an appealing inclusion and membership into what appeared to be an awkward but special type of group status, turns out to be just an unorganized bunch of just-as-stupid people who just happened to stumble into the alternative realm and learn a few things others don’t know, and thus were re-enfranchised from stupidity into a group that believes they are different from the rest – and thus awake. Just like religion…

What does this really mean?

Ultimately, I figured out that the call-you-stupid thing is just an excuse. Not an excuse for everyone else, mind you, but an excuse for the name-caller himself – the awake one, that is. The true agitation among these truth groups is that they can never get anything done; that they cannot create the change they wish to be or see because they never do anything tangible in support of the change other than blaming others for the problems. And so the universal fallacy of an excuse must be that everyone else is stupid, asleep, and sheep because they do not conform to the cornucopia of multiple truths espoused by the awakened. And perhaps this consensus of fallacy is the reason these truth groups are so appealing in the first place. What a perfectly simple-minded concept, that everything is wrong because other people are responsible for the wrongness – but never myself. Never OUR-selves.

In retrospect, it was the perfect cop-out. For as long as other faceless people were responsible for all the world’s problems, it must certainly mean that I was not. I could hide away from my own lack of knowledge with like-minded individuals while, again being akin to Christianity as a sect, we all believed that we were special. We believed we could change the world by spreading our truth through obnoxiousness and guerrilla media. And with this simulated act of armchair confessionals, our souls were somehow being cleared in the real world without actually making any stand whatsoever against the evil for which we preach. There are no real efforts to change real things in real life. Spread the word of truth as if it is the word of God, and the brotherhood of truth will be saved and raptured from that hell we warned the unawake about.

Sounding more and more like religion, isn’t it?

Well, you know what? It worked. Truth groups stand as their own form of controlled opposition. We may have had some meger success at converting the stupid into the church of truth. But it only worked on those looking for a fallacious excuse to blame everyone else for the problems of the world while in actuality doing nothing about it, which is a fairly small community of stupids. It only worked on those who were tired of feeling alone in their contemplation of such a screwed up political system, and thus were already searching for like-minded people to blame for all the problems they couldn’t and honestly didn’t really want to fix. Complaining is sufficient and paramount to curing, apparently.

Unfortunately, the drop-out rate is also quite high in these truther groups because of this strange notion of truth being so multi-faceted as to include all different types of truths to explain just one truth. There seems to be more debate than consensus among truthers, and most members are followers instead of leaders that will accept unrealistic truths just to fit in.

Perhaps most disturbing are the shock-jocks like Alex Jones, whose mega-corporation infiltrates and promotes on-air these groups while selling their members his own version of the truth. Ultimately, the group settles by consensus on which activism materials, bumper stickers, DVD’s, and other purchasable items to use and hand out, many of them from Jones’s “Infowars” mega-franchise. It’s very similar to the cheap plastic gizmo scheme in China under the doctrine of planned obsolescence, where disposable products mean future repeat customers. His brilliant but ultimately evil marketing strategy is simply to copy and hand out his purchased materials, in hopes of bringing ever more worker bees into his profitable media hive of Infowars corporations. And it works. For most people prefer to purchase his products of re-presented “truth” than to take them for free. This type of psychological approach to sales is certainly not new. But perhaps in this movement it was perfected by Jones. Selling through fear and intimidation, the Infowars franchise has turned into a truth monster, offering everything the paranoid truther could possibly need while he or she waits for the economic apocalypse. For the truther often cocoons and transcends into the slightly evolved prepper – creating two customers in one by splitting the personality of each. And the alternative and mainstream commercial machine is now specifically catering to this multi-billion dollar industry to furnish those with the mindset of some pre-ordained truther knowledge of the apparent truth of a future, yet unpredictable financial collapse with the products and services they’ll need to survive like cockroaches in a holocaust.

But the notion of actually correcting or changing the system so that this collapse doesn’t actually happen seems to now be just a sweet memory of what activism was intended to promote – the change we wish to be and see. A simulacra of truth has blossomed, where the battle is against words and opinions instead of against the physicality and reality of what will cause the apocalypse.

For truth is merely simulated reality – the perception of what is without knowing what is…


“The simulacrum is never what hides the truth –
it is truth that hides that fact that there is none.
The simulacrum is true.” 



Sadly, this mentality of preparation has taken over the rationality of the awakened. It is as if instead of simply stepping out of the way of an oncoming bus or somehow making it stop before it hits us, we are sold on the idea that it is better to prepare for the symptoms of the bus hitting us at full speed without even attempting to get out of the way or prevent it. After all, the system is collapsing not because of us, but because of the stupid people. Like corporate Christians, we pretend to be prepared for the rapture while not trying to stop it from happening. The ultimate cop out!

Fixing the problems would be unprofitable for the likes of Jones and company. His sponsors would go broke, unable to sell their wares where no fear exists; the same profit model of any mainstream television or radio network. And now that I think about it, those truther groups are likely more successful at scaring people into fear-based purchases than they are at informing them of reality; which is great for the profit driven fear industry that the truth movement seems to have become just a marketing tool for.

Perhaps this explains why the mainstream media, especially Fox News and its so-called alternative “patriot” network, is following in the footsteps of the Infowar machine. As the likes of Glenn Beck, Sean Hannity, and other talking heads with multi-million dollar contracts spew fear and violence as their top stories, I’ve noticed that their commercials are now strangely imitative of those on the alternative news fear porn networks. Ads for storable food, gold and silver, alternative healing and medicines, and other patriotic-sounding “alternative” products permeate the mainstream airwaves: an almost exact profit-based model taken over from the alternative radio syndicate. It’s nothing more than the master selling his servants their own imagination, in preparation not for what is, but for what could happen.

As a former member of these groups like We Are Change, I can only say this. Get over yourselves! I did. The pre-scripted game plan is not working, and seems to me in fact to be working to the advantage of your adversaries, including Infowars and the like. The war is not over information, for most of that is the truth of ill-informed informers. It is extraneous secular information that is preventing you from acting like men, believing in a legal law that supports tyranny and plunder instead of fighting it with the passion and blood of old. You protest government from a safe distance in free speech zones. You pretend to battle the courts by never entering into them. You speak about government where your voice is never heard by government. You speak truth but never act within it. You store food but never feed the hungry. You replenish your storage when after 5 years surprise!, nothing has changed. You hoard gold and silver in preparation of a dollar collapse while still valuing it in those same dollars. You demonize the Crown, the Fed, the Treasury, the banks, and the banker Rothschilds even as they set the artificial market price of gold each day in the City of London – the same gold that you hoard. You go through the motions of preparation for the un-preparable. You stockpile guns and ammo with no intention to use them to solve these problems (the original intent), only to protect your just-in-case stash for when the problems perpetuate. You hope or pray instead of taking action. You use truth as an insult to those who don’t see it. You expose without consequence and enlighten without cause or action. You are victims of your own paradigm… bound in chains and controlled by the very information you pretend will set others free.

None of this is rational behavior.

I should know, I was one of you…

There is no such thing as being awake when you are living in and as this legal fiction, where truth is always a lie.

If you’ve gotten this far (without being irrationally insulted), you might find this helpful:

Link–> https://realitybloger.wordpress.com/2014/01/22/its-time-to-join-the-reality-movement/

Link–> https://realitybloger.wordpress.com/2013/02/26/social-media-the-simulation-of-action/


–Clint Richardson (realitybloger.wordpress.com)
–Wednesday, November 26th, 2014

Can The President Really Make Law?

Ah yes, the frenzy of false media punditry, memes, and speculation strikes again…

CNN, ABC, FOX, NBC, CBS, and all of the bought-and-paid-for U.S. media corporations, now more than ever acting within their prescribed “Mockingbird” rhetorical nonsense, are yet again confusing a very simple concept while relying on the ignorance of the citizenslaved population. A hidden past creates even a hidden present, where the actions of government seem to draw their authority from the ether of the unknown.

And as Obama’s presidential declaration of what is to become the militarized (executive) legal law in the form of an Executive Order forced upon the United States and its people to create “Mexicamerica” is being hailed even by a dishonest Congress as unconstitutional, the propaganda is getting ass-deep. In this classic false dialectic, the congress is once again pretending (lying) to its subject-citizenry that its hands are tied; that the president is acting in a rogue capacity while ignoring “the people’s will” of the congress. All this is merely another attempt to hide the reality that the President is a real, Congressional confirmed and approved and confirmed dictator under emergency war powers.

Let me once again set the record straight… with the congressional record, that is.

In 1933, Congress voluntarily made this little legislative law that all but stripped itself of its own powers to stop such outrageous whims of the president by declaring that the Office of President shall from that point forward have dictatorial powers without need of vote or congressional approval.  In the Act of March 9, 1933, Title 1, Section 1, congress itself declared:

“The actions, regulations, rules, licenses, orders and proclamations heretofore or hereafter taken, promulgated, made or issued by the President of the United States or the Secretary of the Treasury since March the 4th, 1933, pursuant to the authority conferred by subsection b of Section 5 of the Act of October 6, 1917, as amended, are hereby approved and confirmed.”

It was thus codified, and later slightly altered to this:

“The actions, regulations, rules, licenses, orders and proclamations heretofore or hereafter taken, promulgated, made or issued by the President of the United States or the Secretary of the Treasury since March the 4th, 1933, pursuant to the amended [12 USC Sec. 95a], are hereby approved and confirmed. (Mar. 9, 1933, c. 1, Title 1, Sec. 1, 48 Stat, 1.)”

And today it can be found in the U.S. Code in Title 50, entitled “War And National Defense,” and verbatum above as Title 12 Subsection 95a, here:

Link–> http://www.law.cornell.edu/uscode/text/12/95b


What was the reaction by the few good men at the time who vehemently opposed such a travesty of interpretive law?

In 1933, at the inception, deliberation, and creation of this official usurpation of the powers and authority of Congress over its Executive (Corporation Sole Roosevelt), Congressman James M. Beck spoke officially, stating (from the Congressional Record):

“I think of all the damnable heresies that have ever been suggested in connection with the Constitution, the doctrine of emergency is the worst. It means that when Congress declares an emergency, there is no Constitution. This means its death. It is the very doctrine that the German chancellor is invoking today in the dying hours of the parliamentary body of the German republic, namely, that because of an emergency, it should grant to the German chancellor absolute power to pass any law, even though the law contradicts the Constitution of the German republic. Chancellor Hitler is at least frank about it. We pay the Constitution lip-service, but the result is the same… the Constitution of the United States, as a restraining influence in keeping the federal government within the carefully prescribed channels of power, is moribund, if not dead. We are witnessing its death-agonies, for when this bill becomes a law, if unhappily it becomes a law, there is no longer any workable Constitution to keep the Congress within the limits of its Constitutional powers… This vast range of powers, taken together, confer enough authority to rule the country without reference to normal constitutional processes. Under the powers delegated by these statutes, the President may: seize property; organize and control the means of production; seize commodities, assign military forces abroad; institute martial law; seize and control all transportation and communication; regulate the operation of private enterprise; restrict travel; and, in a plethora of particular ways, control the lives of all American citizens.”


It is important to note that Congressman Beck resigned his seat from the Legislature one year later, in September of 1934, and was quoted as giving the reason for his resignation. He stated that Congress had become “merely a rubber stamp for the Executive.”

Then newly elected criminal-minded president Franklin D. Roosevelt in his inaugural address on March 4rth, 1933 stated :

“I am prepared under my constitutional duty to recommend the measures that a stricken nation in the midst of a stricken world may require. These measures, or such other measures as the Congress may build out of its experience and wisdom, I shall seek, within my constitutional authority, to bring to speedy adoption. But in the event that the Congress shall fail to take one of these two courses, and in the event that the national emergency is still critical, I shall not evade the clear course of duty that will then confront me. I shall ask the Congress for the one remaining instrument to meat the crisis ­ broad Executive power to wage a war against the emergency, as great as the power that would be given to me if we were in fact invaded by a foreign foe.”


And Congress granted happily and speedily that mutually beneficial request by the president to allow the office to be dictator under the doctrine of necesity, as we read above in U.S. Code.

“Be it enacted by the Senate and the House of Representatives of the United States of America in Congress assembled, that the Congress hereby declares that a serious emergency exists and that it is imperatively necessary speedily to put into effect remedies of uniform national application.”

This became the “Act of March 9, 1933″, as written into Congressional law.


Later in the congressional record, we find other honest appeals to the insanity of a congress that at any time can stop this power of the president with new legislation, but chooses in free will not to do so. This continuous state of multiple declarations of national emergency was speculated upon long ago as the road to dictatorship and martial law in America, again reading from within the congressional record:

“The President has the power to seize property, organize and control the means of production, seize commodities, assign military forces abroad, call reserve forces amounting to 2 1/2 million men to duty, institute martial law, seize and control all means of transportation, regulate all private enterprise, restrict travel, and in a plethora of particular ways, control the lives of all Americans…

“Most [of these laws] remain a potential source of virtually unlimited power for a President should he choose to activate them. It is possible that some future President could exercise this vast authority in an attempt to place the United States under authoritarian rule.

“While the danger of a dictatorship arising through legal means may seem remote to us today (in 1973), recent history records Hitler seizing control through the use of the emergency powers provisions contained in the laws of the Weimar Republic.”

–Joint Statement, Senators Frank Church (D-ID) and Charles McMathias (R-MD) September 30, 1973.


Why did these men have such horrific predictions for our current future?

In 1973, the Senate was charged with compiling a report of which it was to decide upon the efficacy and necessity of the continuance of these Emergency War Powers of the Executive Branch, showing that congress certainly has the power to end this nightmare at any time. This report was named Senate Report 93-549, and was commissioned by the “Special Committee on the Termination of the National Emergency”.

The report’s introduction opens as such:

Since March the 9th, 1933, the United States has been in a state of declared national emergencyA majority of the people of the United States have lived all their lives under emergency ruleFor 40 years, freedoms and governmental procedures guaranteed by the Constitution have, in varying degrees, been abridged by laws brought into force by states of national emergency… And, in the United States, actions taken by the government in times of great crisis have ­ from, at least, the Civil War ­ in important ways shaped the present phenomenon of a permanent state of national emergency.”


In order to cut through all of the bullshit that is being espoused by both mainstream and alternative armchair commentators, let this truth stand as an un-shattering reality. The congress voluntarily gave away its power to say no in 1933 in an official capacity, knowingly allowing all future presidents (the office) to declare and order any thing they wish as law. This is voluntary. And this act in U.S. Code can be reversed any time that congress wishes. The problem is, they don’t disapprove of the presidents actions, accept in public forums where the idiots who vote for them can see them pandering and appealing to the sympathy of the unknowing masses.

They say their hands are tied, and yes that is true. But they control the rope. They made the law that ties their hands, and at any time at all they can unmake that law.

But what would happen then? What would happen if this office of dictator were suddenly de-authorized?

That would mean congress would lose all of its modern post-war emergency power! It would mean that all “actions, regulations, rules, licenses, orders and proclamations heretofore or hereafter taken, promulgated, made or issued by the President of the United States or the Secretary of the Treasury since March the 4th, 1933,” would lose their authority. For emergency powers are supposed to be as temporary as any other declaration of war. But the wars against all the declared emergencies are still in effect, and even the Federal Reserve, which was created in a state of emergency under the auspices of the “Emergency Banking Act”, would need to necessarily be put to rest. Literally, the only way that congress can have so much power is to allow the president dictatorial power by vesting that power through congress to the office of president. Thus, the Hegelian dialectic is perfected within a false competition between congress and the monster it created and can destroy at any time.

Make no mistake, folks, congress is not opposed to legalization of illegal aliens into the nation. The more debt slaves the better. But rest assured that you are about to see endless congressional debate and media talking heads spouting more B.S. than you can stomach, all in the name of hiding the fact that you live in a pre-confirmed dictatorship that is both approved and continued perpetually and voluntarily by the United States Congress assembled.

Stop saying that everything that is happening in Washington is unconstitutional damn it! This law was in 1933 passed to bypass the constitution through emergency power!!! So guess what… that means that everything is “constitutional” by necessity  under a suspended constitution! Necessity is a state of lawlessness!!!

You want to change the political spectrum? Get the truth out. Embarrass congress when they lie and pretend that their political hands are tied. Demand that this reality be the one and only political subject and topic of debate at the presidential elections. Demand that this permanent declared state of emergency be banished by this and any future president and the law allowing this Congressional appointed dictatorship abolished. For this is the very soul of Homeland Security, the Patriot Acts, and all other emergency acts, declarations, and Executive Orders that violate every possible right imaginable. Without the power of emergency and war, which is the power of necessity (necessity knows no law), everything would have to go back to what it was before the military ruled the nation through executive force under emergency war powers.

Without this power and authority, congress would need to once again recognize the limitations to itself by the constitution, for necessity knows no constitution, either.

Until you stand up, foreigners are going to come. Illegal wars will be waged. Oppression will ensue. And the president will be dictator with the full and unfettered legal support of you, the People, as re-presented in congress.

The truth is that you are a militarily and politically defeated people.

You perish from lack of knowledge.

And admitting that is the first step…


–Clint Richardson (Realitybloger.wordpress.com)
–Friday, November 21st, 2014

Searching For Palestinian Soldiers

I clicked onto a random Youtube video today; one of the multitude bearing the familiar tag line of “Israeli Soldiers Abuse Palestinian _____.”

As I listened, it turned out instead to be the typical defense of Israel type of plea. The subject was the recent peace talks between Palestine and the Israeli “State”. And of course the narrator lamented upon the poor Israelis having a disadvantage in those talks. And now they’ve broken down yet again.

As I thought about her words juxtaposed to the film footage of Israeli soldiers engaging Palestinian pedestrians, a wonderfully ticklish feeling of confidence and sorrow came over me as I constructed an idea…

Even before I asked myself the question, I knew to my bones the answer. I didn’t just know it, I felt it.

Any time a man can dispel his own cognitive dissonance by logically destroying his own fallacious thought patterns programed since birth, a feeling of liberation and relief follows. Today, I found the ultimate weapon to showcase the true purveyors of abuse in the Holy Land. So simple…

And so I grabbed my keyboard and mouse to verify my new revelation.

First, I re-visited Youtube to utilize my two-part verification method. Therein I typed the phrase:


Up came a massive collection of video clips that showed Israeli soldiers interacting violently with the non-uniformed, non-militarized, Palestinian people. Abuse, bloodied and dismembered children, depleted uranium-exposed people on both sides, executions, violent arrests, child and elderly abuse, and all-around disrespect of life and liberty shown 100 times over; armed guards against an unarmed people.

Now came the victory dance. For I then typed into the search box the words:


Now I didn’t expect to see very many videos of Palestinian Soldiers, but I was a bit shocked at my own ignorance to see that not only were there no videos at all showing Palestinian soldiers, but the same exact videos that came up with my previous search appeared on the screen, again showing Israeli soldiers abusing Palestinian men, woman, and children.

Just to be a bit more clear, I typed in a different search:


Of the 15 or so videos that came up, one was titled “Horse abuse by Palestinian on Jewish Land”.

The other videos were titled as follows:

Orthodox Jewish woman harasses Palestinian mother

Jewish settler hate

American Jew Abused in Israel Tel Aviv… (refering to Israeli Jew on American Jew – jew on jew – crime)

More Palestinian/Hamas Child Abuse. Kids TV

Life in Palestine under Jewish Occupation

Newt Gingrich trying to show loyalty to Israel by abusing Palestinian rights!

Historical Images: 900,000 Palestinians Fleeing,
Tens of Thousands of Jews Seizing their Homes

Israeli Checkpoints: Assaulting International Observers and Abusing Palestinians in Hebron

Israeli Soldiers & Police Attack Palestinian Children When Playing Near Al Aqsa

Mizrahi Jews steal Palestinian homes


So where is the Palestinian Army? Police? Soldiers? Anyone?

Where are all the videos of them abusing the Jews? Because they appear to be almost non-existent!

And then I thought… really? The organized efforts of the ADL, AIPAC, dozens of duel-Israeli citizen Cabinet members and politicians, the Christian/Jewish alliance, the CIA and the Mossad working side by side, and countless other pro-Israeli organizations and congresses… and they didn’t think to flood Youtube with either real or fake videos of Palestinians abusing Jews? I laughed out loud at the thought that this stupid little after-thought just turned into the most honest, in your face proof through logic, reason, and sheer in your face video evidence and fact, that the Palestinian people are completely suppressed by the Israeli army and have no weapons or army to fight back with. They have sticks and stones against sub-machine guns, tanks, planes, and a holy horror of illegal weapons designed for maximum carnage and suffering.

Incidentally, It is important to mention that I could find no videos or articles of Palestinians stealing any Jewish land or homes.

And of course, as I deconstructed the true situation over there, I realized that the Palestinian people have no army, navy, air force, or any protective force at all.

That’s the people. The people are defenseless, bravely using their own bodies as their only weapons, often in defense of their families and communities.

The Palestinian government, if you can call it that, is a bit different.

From Wikipedia:

The signing of the Oslo Accords in September 1993 brought about the establishment of the Palestinian National Authority. With the opening of Gaza International Airport, the PNA established a 200-strong Aviation Police (Shurta al-Jawiya), subordinate to the Palestinian Civil Aviation Department and based on Force 14 personnel. Consisting mainly of guards and security personnel, the unit initially also comprised crews responsible for maintaining and operating the authority’s fleet of three Mil Mi-17 helicopters. These, however, were all destroyed by the Israeli Air Force on December 3, 2001, during the Al-Aqsa Intifada.

The Palestinian Security Force is financed by the United States which, according to media estimates, pays an annual 3 million dollars for it.

As the Israeli-Palestinian conflict goes on, the security forces notably co-operate with other law enforcement agencies, such as arresting militant sub-groups and assisting the Israeli government with prosecuting those picked up. According the Jerusalem Post as well, “In the past, Palestinian security forces have released arrested terrorists and then quietly tipped off Israel to mitigate internal public criticism against handing over Palestinians to Israel.”

From the late 1990s, the CIA played the central role in building up PA security forces, in close co-operation with the Israeli military and intelligence. After the killing of three US officials in the Gaza strip in 2003, British forces played an increasingly active role.

Mohammed Dahlan was the first chief of the Palestinian Security Force in Gaza from 1994 to 2002. Dahlan was replaced by Rashid Abu Shbak. Jibril Rajoub was the chief president of the Palestinian Security Force in the West Bank and was replaced in 2002 by Zuhair Manasra.

The current state and activities of Force 14 are unknown, though it was reportedly still sending recruits on various training courses throughout the world in the mid 1990s.


Hmm… Well then, what happened to the Palestinian Liberation Army (PLA)?

Considering its enemy is the Israeli “Defense” Forces (IDF), they don’t exist in Palestine anymore. However, it has been reported that approximately 4,500 PLA members remain in Syria.

Wikipedia reports that:

PLA soldiers later became the core of the Palestinian Authority’s (PNA) National Guard, after the signing of the 1993 Oslo Accords, when they were allowed to enter the Palestinian Territories to take up positions in the PNA security services.

And what of the Palestinian Authority, which “keeps the peace” in the yet unrecognized status of the Palestinian state?

Palestinians in the diaspora and inside Israel do not vote in elections for the offices of the Palestinian Authority.

As I pondered this notion, I came to the startling realization that this is almost the exact story of what America went through, where it’s militias were demonized and replaced by the United States central government’s peace-keeping version of the lawful militia, called the Federal de facto “National Guard”. The people do not vote for their peace-keepers here either… but then the American people have no idea they are a militarily occupied union under the Leiber Code. Just like in Palestine, the army and the guards are there to protect government from the people, not the other way around.

So then what, pray tell, would happen if I searched the whole Internet for some small trace of a resisting Palestinian Army?

And this is about where I kicked myself…

Dear God!, I realized. Palestine is a country with no defense! It has no army, navy, air force, or any force at all – except the undying will of a totally oppressed people! Of course the Palestinians have no army. They have no ships or planes. They have nothing but their lands and homes; though this appears to be a conditional use at best, until the so-called Israeli “Jews” steal them while claiming right of return to a place they do not belong and have no actual historical right to claim.

So I’m supposed to believe it when the media states that the poor, poor Israeli “Jews” are being abused by a people with no military authority or force whatsoever, and that this justifies the most brutal of retaliation and genocide? By a people that don’t even have access to most streets? By a people oppressed in every conceivable way through Apartheid tactics? By people so desperate as to throw sticks and stones because all of their weapons and planes were confiscated or destroyed by the Israelis (which the United States paid for)?

Is there any greater internationally syndicated fallacy today then that of the cry of these oppressors as an appeal to their theft and murder of innocent men, women, and children in the name of plunder and racial superiority? Can we really expect anything less in our own lands if we stand by and do nothing as our own government’s contribute billions and billions to this travesty of morality and international law? Are we ourselves so corrupted by Talmudic, Zionist devices, brainwashing, and false patriotism that we silently consent to this atrocity in infinitude, even while our own governments around the world fund it?

Perhaps the Muslim’s are chanting and cheering “death to America” because they realize that the wholly Zionist United States government and its complacent, tacitly consenting, brainwashed people are the only thing keeping the “state” of Israel alive? Well, that and the Crown Corporation Sole, which militarily took over Palestine in the first place to reclaim its “Kingdom of Jerusalem.”

Ugh… now I’ve done it. I must officially be un-American, anti-Semitic, and a domestic terrorist for speaking the truth.

Give me a fucking break!


–Clint Richardson (Realitybloger.wordpress.com)
–Wednesday, November 12th, 2014

The Corporation Nation Radio Show Archives

I’d like to give a special thanks to a very gracious activist, who took the time to create this website and will be recording and posting my radio shows commercial free. Enjoy…

Link–> http://corporationnationradioarchives.wordpress.com/

All of the Republic Broadcasting Network show archives can be accessed on RBN’s website for a nominal membership fee:

Link–> http://republicbroadcasting.org/

Join me later today (5-7pm Pacific Zone) with my special guest Freeman Burt on the fictions of law and how they entrap you.

Tomorrow Gary Long will join me for a discussion about the legal “testament” of the Bible – the basis of all “civil” law!!!


–Clint Richardson (realitybloger.wordpress.com)
–Thursday, October 17th, 2013